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Chemical Compound Review

pargyline     N-benzyl-N-methyl-prop-2-yn- 1-amine

Synonyms: Pargylin, Supirdyl, Eudatin, Eutonyl, Pargilina, ...
 
 
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Disease relevance of pargyline

 

Psychiatry related information on pargyline

 

High impact information on pargyline

 

Chemical compound and disease context of pargyline

 

Biological context of pargyline

 

Anatomical context of pargyline

 

Associations of pargyline with other chemical compounds

 

Gene context of pargyline

  • But in the case of pargyline, the enzymes displayed opposite stereoselectivity, FMO1 producing solely the (+)-enantiomer and FMO3 predominantly the (-)-enantiomer of the N-oxide [32].
  • Furthermore, we identify pargyline as an inhibitor of LSD1 [33].
  • Pargyline blocks demethylation of H3-K9 by LSD1 and consequently androgen-receptor-dependent transcription [33].
  • A bolus infusion of leptin (1.0 microg) into the lateral ventricle (ilvt) significantly elevated the turnover rate of hypothalamic neuronal histamine, as assessed by pargyline-induced accumulation of t-MH, in ob/ob mice compared with phosphate-buffered saline (PBS) infusions (P < 0.05) [34].
  • (+)-Deprenyl did not increase PC12 cell survival, and, with the exception of pargyline, other MAO-A and MAO-B inhibitors did not alter apoptotic death [35].
 

Analytical, diagnostic and therapeutic context of pargyline

References

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  15. Duodenal ulcer induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Szabo, S., Brown, A., Pihan, G., Dali, H., Neumeyer, J.L. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
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  23. Mechanisms of alcohol impairment of recovery from mechanically denuded areas made within cultured rat hepatocytes. Anderson, R.J., Sponsel, H.T., Brown, S.E., Breckon, R., Ray, C., Simon, F.R., Guzelian, P.S. Hepatology (1997) [Pubmed]
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  29. Structural comparison of human monoamine oxidases A and B: mass spectrometry monitoring of cysteine reactivities. Hubalek, F., Pohl, J., Edmondson, D.E. J. Biol. Chem. (2003) [Pubmed]
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  31. Decreased brain serotonin turnover after short term (two-hour) adrenalectomy in rats: a comparison of four turnover methods. Van Loon, G.R., Shum, A., Sole, M.J. Endocrinology (1981) [Pubmed]
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  33. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Metzger, E., Wissmann, M., Yin, N., Müller, J.M., Schneider, R., Peters, A.H., Günther, T., Buettner, R., Schüle, R. Nature (2005) [Pubmed]
  34. Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain. Itateyama, E., Chiba, S., Sakata, T., Yoshimatsu, H. Exp. Biol. Med. (Maywood) (2003) [Pubmed]
  35. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. Tatton, W.G., Ju, W.Y., Holland, D.P., Tai, C., Kwan, M. J. Neurochem. (1994) [Pubmed]
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  38. Neuronal glucoprivation enhances hypothalamic histamine turnover in rats. Oohara, A., Yoshimatsu, H., Kurokawa, M., Oishi, R., Saeki, K., Sakata, T. J. Neurochem. (1994) [Pubmed]
  39. Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain. Oishi, R., Itoh, Y., Nishibori, M., Saeki, K. J. Neurochem. (1989) [Pubmed]
 
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