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Chemical Compound Review

pargyline     N-benzyl-N-methyl-prop-2-yn- 1-amine

Synonyms: Pargylin, Supirdyl, Eudatin, Eutonyl, Pargilina, ...
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Disease relevance of pargyline


Psychiatry related information on pargyline


High impact information on pargyline


Chemical compound and disease context of pargyline


Biological context of pargyline


Anatomical context of pargyline


Associations of pargyline with other chemical compounds


Gene context of pargyline

  • But in the case of pargyline, the enzymes displayed opposite stereoselectivity, FMO1 producing solely the (+)-enantiomer and FMO3 predominantly the (-)-enantiomer of the N-oxide [32].
  • Furthermore, we identify pargyline as an inhibitor of LSD1 [33].
  • Pargyline blocks demethylation of H3-K9 by LSD1 and consequently androgen-receptor-dependent transcription [33].
  • A bolus infusion of leptin (1.0 microg) into the lateral ventricle (ilvt) significantly elevated the turnover rate of hypothalamic neuronal histamine, as assessed by pargyline-induced accumulation of t-MH, in ob/ob mice compared with phosphate-buffered saline (PBS) infusions (P < 0.05) [34].
  • (+)-Deprenyl did not increase PC12 cell survival, and, with the exception of pargyline, other MAO-A and MAO-B inhibitors did not alter apoptotic death [35].

Analytical, diagnostic and therapeutic context of pargyline


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  2. Pargyline prevents MPTP-induced parkinsonism in primates. Langston, J.W., Irwin, I., Langston, E.B., Forno, L.S. Science (1984) [Pubmed]
  3. Testosterone-attenuated stereotype and hyperactivity induced by beta-phenylethylamine in pargyline-pretreated rats. Freemark, M., Stoff, D.M., Moja, E.A., Gillin, J.C., Wyatt, R.J. Biol. Psychiatry (1978) [Pubmed]
  4. Effects of estradiol on the diurnal rhythm of serotonin activity in microdissected brain areas of ovariectomized rats. Cohen, I.R., Wise, P.M. Endocrinology (1988) [Pubmed]
  5. Pargyline-induced mania in primary affective disorder: case report. Folks, D., Arnold, E.S. The Journal of clinical psychiatry. (1983) [Pubmed]
  6. Infusion of a monoamine oxidase inhibitor into the locus coeruleus can prevent stress-induced behavioral depression. Simson, P.G., Weiss, J.M., Ambrose, M.J., Webster, A. Biol. Psychiatry (1986) [Pubmed]
  7. Dose-response effects of beta-phenylethylamine on stereotyped behavior in pargyline-pretreated rats. Moja, E.A., Stoff, D.M., Gillin, J.C., Wyatt, R.J. Biol. Psychiatry (1976) [Pubmed]
  8. Biogenic amines and the effect of short term lithium administration on open field activity in rats. Smith, D.F. Psychopharmacologia. (1975) [Pubmed]
  9. Involvement of serotonergic neuronal systems in the anti-amnesic action of naftidrofuryl oxalate. Nabeshima, T., Ichihara, K., Tohyama, K., Murase, K., Suzuki, T., Kameyama, T. Eur. J. Pharmacol. (1991) [Pubmed]
  10. Left ventricular receptors inhibit brain serotonin neurons during coronary artery occlusion. Sole, M.J., Van Loon, G., Shum, A., Lixfield, W., MacGregor, D.C. Science (1978) [Pubmed]
  11. Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors. Cryan, J.F., O'Leary, O.F., Jin, S.H., Friedland, J.C., Ouyang, M., Hirsch, B.R., Page, M.E., Dalvi, A., Thomas, S.A., Lucki, I. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  12. Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Binda, C., Newton-Vinson, P., Hubálek, F., Edmondson, D.E., Mattevi, A. Nat. Struct. Biol. (2002) [Pubmed]
  13. Effects of transient forebrain ischemia and pargyline on extracellular concentrations of dopamine, serotonin, and their metabolites in the rat striatum as determined by in vivo microdialysis. Damsma, G., Boisvert, D.P., Mudrick, L.A., Wenkstern, D., Fibiger, H.C. J. Neurochem. (1990) [Pubmed]
  14. Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atrium. Medhurst, A.D., Kaumann, A.J. Br. J. Pharmacol. (1993) [Pubmed]
  15. Duodenal ulcer induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Szabo, S., Brown, A., Pihan, G., Dali, H., Neumeyer, J.L. Proc. Soc. Exp. Biol. Med. (1985) [Pubmed]
  16. Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies. Harik, S.I., Riachi, N.J., Hritz, M.A., Berridge, M.S., Sayre, L.M. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  17. An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines. Lai, M., Griffiths, H., Pall, H., Williams, A., Lunec, J. Biochem. Pharmacol. (1993) [Pubmed]
  18. Characterization and quantitation of monoamine oxidases A and B in mitochondria from human placenta. Riley, L.A., Waguespack, M.A., Denney, R.M. Mol. Pharmacol. (1989) [Pubmed]
  19. Dopamine autoreceptor regulation of the kinetic state of striatal tyrosine hydroxylase. Strait, K.A., Kuczenski, R. Mol. Pharmacol. (1986) [Pubmed]
  20. Effect of pargyline on brain N-tele-methylhistamine in portocaval-shunted rats: relation to amine neurotransmitters. Fogel, W.A., Tuomisto, L., Sasiak, K., Rokicki, W., Rokicki, M., MacDonald, E., Maslinski, C. J. Neurochem. (1994) [Pubmed]
  21. Dopamine neurotoxicity: inhibition of mitochondrial respiration. Ben-Shachar, D., Zuk, R., Glinka, Y. J. Neurochem. (1995) [Pubmed]
  22. Oxidative stress in a clonal cell line of neuronal origin: effects of antioxidant enzyme modulation. Buckman, T.D., Sutphin, M.S., Mitrovic, B. J. Neurochem. (1993) [Pubmed]
  23. Mechanisms of alcohol impairment of recovery from mechanically denuded areas made within cultured rat hepatocytes. Anderson, R.J., Sponsel, H.T., Brown, S.E., Breckon, R., Ray, C., Simon, F.R., Guzelian, P.S. Hepatology (1997) [Pubmed]
  24. In vivo comparison of the regulation of releasable dopamine in the caudate nucleus and the nucleus accumbens of the rat brain. Kuhr, W.G., Bigelow, J.C., Wightman, R.M. J. Neurosci. (1986) [Pubmed]
  25. Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: posssible relation to gondotropin secretion. Simpkins, J.W., Mueller, G.P., Huang, H.H., Meites, J. Endocrinology (1977) [Pubmed]
  26. 3-Methoxytyramine formation following monoamine oxidase inhibition is a poor index of dendritic dopamine release in the substantia nigra. Elverfors, A., Pileblad, E., Lagerkvist, S., Bergquist, F., Jonason, J., Nissbrandt, H. J. Neurochem. (1997) [Pubmed]
  27. Evidence for the presence of serotonergic nerves and receptors in the iris-ciliary body complex of the rabbit. Tobin, A.B., Unger, W., Osborne, N.N. J. Neurosci. (1988) [Pubmed]
  28. Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Wang, Y., Devereux, W., Woster, P.M., Stewart, T.M., Hacker, A., Casero, R.A. Cancer Res. (2001) [Pubmed]
  29. Structural comparison of human monoamine oxidases A and B: mass spectrometry monitoring of cysteine reactivities. Hubalek, F., Pohl, J., Edmondson, D.E. J. Biol. Chem. (2003) [Pubmed]
  30. Formation and metabolism of dopamine in nine areas of the rat brain: modifications by haloperidol. Westerink, B.H., Bosker, F.J., Wirix, E. J. Neurochem. (1984) [Pubmed]
  31. Decreased brain serotonin turnover after short term (two-hour) adrenalectomy in rats: a comparison of four turnover methods. Van Loon, G.R., Shum, A., Sole, M.J. Endocrinology (1981) [Pubmed]
  32. The molecular biology of the flavin-containing monooxygenases of man. Phillips, I.R., Dolphin, C.T., Clair, P., Hadley, M.R., Hutt, A.J., McCombie, R.R., Smith, R.L., Shephard, E.A. Chem. Biol. Interact. (1995) [Pubmed]
  33. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Metzger, E., Wissmann, M., Yin, N., Müller, J.M., Schneider, R., Peters, A.H., Günther, T., Buettner, R., Schüle, R. Nature (2005) [Pubmed]
  34. Hypothalamic neuronal histamine in genetically obese animals: its implication of leptin action in the brain. Itateyama, E., Chiba, S., Sakata, T., Yoshimatsu, H. Exp. Biol. Med. (Maywood) (2003) [Pubmed]
  35. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. Tatton, W.G., Ju, W.Y., Holland, D.P., Tai, C., Kwan, M. J. Neurochem. (1994) [Pubmed]
  36. The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells. Marini, A.M., Schwartz, J.P., Kopin, I.J. J. Neurosci. (1989) [Pubmed]
  37. Use of a monoclonal antibody for comparative studies of monoamine oxidase B in mitochondrial extracts of human brain and peripheral tissues. Denney, R.M., Fritz, R.R., Patel, N.T., Widen, S.G., Abell, C.W. Mol. Pharmacol. (1983) [Pubmed]
  38. Neuronal glucoprivation enhances hypothalamic histamine turnover in rats. Oohara, A., Yoshimatsu, H., Kurokawa, M., Oishi, R., Saeki, K., Sakata, T. J. Neurochem. (1994) [Pubmed]
  39. Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain. Oishi, R., Itoh, Y., Nishibori, M., Saeki, K. J. Neurochem. (1989) [Pubmed]
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