High impact information on GPAM

• Genomic structure and an alternative transcript of bovine mitochondrial glycerol-3-phosphate acyltransferase gene (GPAM) [1].
• Adipose tissues and lung had the highest levels of GPAM mRNA expression, whereas it was barely detectable in liver [1].
• The predicted amino acid sequence had an 89 and 93% similarity with mouse and human GPAM proteins, respectively [1].
• Glycerol-3-phosphate acyltransferase mitochondrial (GPAM) is the enzyme that catalyses the initial and committed step of glycerolipid synthesis and, therefore, it is a potential site for triacylglycerol synthesis regulation [1].
• Fatty acid synthase (FASN) and glycerol-3-phosphate acyltransferase mitochondrial (GPAM) are two enzymes that play a central role in de novo lipogenesis [2].

Biological context of GPAM

• Assignment of mitochondrial glycerol-3-phosphate acyltransferase (GPAM) gene to bovine chromosome 26 (26q22) by in situ hybridization and confirmation by somatic cell hybrid mapping [3].
• Radiation hybrid and genetic linkage mapping of two genes related to fat metabolism in cattle: fatty acid synthase (FASN) and glycerol-3-phosphate acyltransferase mitochondrial (GPAM) [2].
• Several clones containing the fatty acid synthase (FASN) and glycerol-3-phosphate acyltransferase mitochondrial (GPAM) genes were isolated after screening the INRA bovine bacterial artificial chromosome (BAC) library using PCR [2].

Other interactions of GPAM

• Radiation hybrid maps were developed for chromosome BTA19 and BTA26 regions containing FASN and GPAM genes, respectively [2].

References