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Gene Review

FASN  -  fatty acid synthase

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High impact information on FASN


Biological context of FASN


Anatomical context of FASN


Associations of FASN with chemical compounds


Regulatory relationships of FASN


Other interactions of FASN


Analytical, diagnostic and therapeutic context of FASN


  1. Acetoacetyl-CoA reductase activity of lactating bovine mammary fatty acid synthase. Dodds, P.F., Guzman, M.G., Chalberg, S.C., Anderson, G.J., Kumar, S. J. Biol. Chem. (1981) [Pubmed]
  2. The inhibitory effect of trans-10, cis-12 CLA on lipid synthesis in bovine mammary epithelial cells involves reduced proteolytic activation of the transcription factor SREBP-1. Peterson, D.G., Matitashvili, E.A., Bauman, D.E. J. Nutr. (2004) [Pubmed]
  3. Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro. Mobley, J.A., Leav, I., Zielie, P., Wotkowitz, C., Evans, J., Lam, Y.W., L'Esperance, B.S., Jiang, Z., Ho, S.M. Cancer Epidemiol. Biomarkers Prev. (2003) [Pubmed]
  4. Insulin increases lipogenic enzyme activity in human adipocytes in primary culture. Moustaïd, N., Jones, B.H., Taylor, J.W. J. Nutr. (1996) [Pubmed]
  5. Transacylase activity of lactating bovine mammary fatty acid synthase. Anderson, G.J., Kumar, S. FEBS Lett. (1987) [Pubmed]
  6. Assignment of the fatty acid synthase (FASN) gene to bovine chromosome 19 (19q22) by in situ hybridization and confirmation by somatic cell hybrid mapping. Roy, R., Gautier, M., Hayes, H., Laurent, P., Osta, R., Zaragoza, P., Eggen, A., Rodellar, C. Cytogenet. Cell Genet. (2001) [Pubmed]
  7. Fatty acid synthase effects on bovine adipose fat and milk fat. Morris, C.A., Cullen, N.G., Glass, B.C., Hyndman, D.L., Manley, T.R., Hickey, S.M., McEwan, J.C., Pitchford, W.S., Bottema, C.D., Lee, M.A. Mamm. Genome (2007) [Pubmed]
  8. Association of polymorphisms in the bovine FASN gene with milk-fat content. Roy, R., Ordovas, L., Zaragoza, P., Romero, A., Moreno, C., Altarriba, J., Rodellar, C. Anim. Genet. (2006) [Pubmed]
  9. Radiation hybrid and genetic linkage mapping of two genes related to fat metabolism in cattle: fatty acid synthase (FASN) and glycerol-3-phosphate acyltransferase mitochondrial (GPAM). Roy, R., Zaragoza, P., Rodellar, C., Gautier, M., Eggen, A. Anim. Biotechnol. (2005) [Pubmed]
  10. Fatty acid chain elongation by microsomal enzymes from the bovine meibomian gland. Anderson, G.J., Kolattukudy, P.E. Arch. Biochem. Biophys. (1985) [Pubmed]
  11. The influence of bovine growth hormone and growth hormone releasing factor on acetyl-CoA carboxylase and fatty acid synthase in primiparous Holstein cows. Beswick, N.S., Kennelly, J.J. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1998) [Pubmed]
  12. Effect of somatotropin treatment on lipogenesis, lipolysis, and related cellular mechanisms in adipose tissue of lactating cows. Lanna, D.P., Houseknecht, K.L., Harris, D.M., Bauman, D.E. J. Dairy Sci. (1995) [Pubmed]
  13. Decarboxylation of malonyl-CoA by lactating bovine mammary fatty acid synthase. Svoronos, S., Kumar, S. Comp. Biochem. Physiol., B (1988) [Pubmed]
  14. Acetyl CoA carboxylase shares control of fatty acid synthesis with fatty acid synthase in bovine mammary homogenate. Wright, T.C., Cant, J.P., Brenna, J.T., McBride, B.W. J. Dairy Sci. (2006) [Pubmed]
  15. Unrestricted feed intake during the dry period impairs the postpartum oxidation and synthesis of fatty acids in the liver of dairy cows. Murondoti, A., Jorritsma, R., Beynen, A.C., Wensing, T., Geelen, M.J. J. Dairy Sci. (2004) [Pubmed]
  16. Nutritional status induces divergent variations of GLUT4 protein content, but not lipoprotein lipase activity, between adipose tissues and muscles in adult cattle. Bonnet, M., Faulconnier, Y., Hocquette, J.F., Bocquier, F., Leroux, C., Martin, P., Chilliard, Y. Br. J. Nutr. (2004) [Pubmed]
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