Gene Review:
NGF - nerve growth factor (beta polypeptide)
Homo sapiens
Synonyms:
Beta-NGF, Beta-nerve growth factor, HSAN5, NGFB
- NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. Zhang, X., Huang, J., McNaughton, P.A. EMBO J. (2005)
- Neurotrophins and hyperalgesia. Shu, X.Q., Mendell, L.M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Structural gene for beta-nerve growth factor not defective in familial dysautonomia. Breakefield, X.O., Orloff, G., Castiglione, C., Coussens, L., Axelrod, F.B., Ullrich, A. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Human eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli. Kobayashi, H., Gleich, G.J., Butterfield, J.H., Kita, H. Blood (2002)
- BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Phillips, H.S., Hains, J.M., Armanini, M., Laramee, G.R., Johnson, S.A., Winslow, J.W. Neuron (1991)
- The changing sensitivity in the life of the nociceptor. Koltzenburg, M. Pain (1999)
- Role of the neurotrophic factors BDNF and NGF in the commitment of pluripotent neural crest cells. Sieber-Blum, M. Neuron (1991)
- Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease. Mufson, E.J., Kordower, J.H. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration. Chen, K.S., Gage, F.H. J. Neurosci. (1995)
- Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Indo, Y., Tsuruta, M., Hayashida, Y., Karim, M.A., Ohta, K., Kawano, T., Mitsubuchi, H., Tonoki, H., Awaya, Y., Matsuda, I. Nat. Genet. (1996)
- Nerve growth factor is an autocrine survival factor for memory B lymphocytes. Torcia, M., Bracci-Laudiero, L., Lucibello, M., Nencioni, L., Labardi, D., Rubartelli, A., Cozzolino, F., Aloe, L., Garaci, E. Cell (1996)
- Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Thomas, S.M., DeMarco, M., D'Arcangelo, G., Halegoua, S., Brugge, J.S. Cell (1992)
- Coexpression of messenger RNA for TRK protooncogene and low affinity nerve growth factor receptor in neuroblastoma with favorable prognosis. Kogner, P., Barbany, G., Dominici, C., Castello, M.A., Raschellá, G., Persson, H. Cancer Res. (1993)
- The neuropeptide pituitary adenylate cyclase activating protein stimulates human monocytes by transactivation of the Trk/NGF pathway. El Zein, N., Badran, B.M., Sariban, E. Cell. Signal. (2007)
- The expression of neurotrophins and their receptors in the prenatal and adult human testis: evidence for functions in Leydig cells. Müller, D., Davidoff, M.S., Bargheer, O., Paust, H.J., Pusch, W., Koeva, Y., Jezek, D., Holstein, A.F., Middendorff, R. Histochem. Cell Biol. (2006)
- A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. Einarsdottir, E., Carlsson, A., Minde, J., Toolanen, G., Svensson, O., Solders, G., Holmgren, G., Holmberg, D., Holmberg, M. Hum. Mol. Genet. (2004)
- Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes. Dracopoli, N.C., Rose, E., Whitfield, G.K., Guidon, P.T., Bale, S.J., Chance, P.A., Kourides, I.A., Housman, D.E. Genomics (1988)
- Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis. Buchberg, A.M., Jenkins, N.A., Copeland, N.G. Genomics (1989)
- Mapping the human amylase gene cluster on the proximal short arm of chromosome 1 using a highly informative (CA)n repeat. Dracopoli, N.C., Meisler, M.H. Genomics (1990)
- Neurotrophin-6 is a new member of the nerve growth factor family. Götz, R., Köster, R., Winkler, C., Raulf, F., Lottspeich, F., Schartl, M., Thoenen, H. Nature (1994)
- Human beta-nerve growth factor gene sequence highly homologous to that of mouse. Ullrich, A., Gray, A., Berman, C., Dull, T.J. Nature (1983)
- The human gene for the beta subunit of nerve growth factor is located on the proximal short arm of chromosome 1. Francke, U., de Martinville, B., Coussens, L., Ullrich, A. Science (1983)
- The nerve growth factor family of receptors. Meakin, S.O., Shooter, E.M. Trends Neurosci. (1992)
- Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Wiesmann, C., Ultsch, M.H., Bass, S.H., de Vos, A.M. Nature (1999)
- Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3. Knüsel, B., Winslow, J.W., Rosenthal, A., Burton, L.E., Seid, D.P., Nikolics, K., Hefti, F. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Efficient processing and expression of human nerve growth factor receptors in Xenopus laevis oocytes: effects on maturation. Sehgal, A., Wall, D.A., Chao, M.V. Mol. Cell. Biol. (1988)
- Nerve growth factor: structure and function. Wiesmann, C., de Vos, A.M. Cell. Mol. Life Sci. (2001)
- Monoamine-activated alpha 2-macroglobulin binds trk receptor and inhibits nerve growth factor-stimulated trk phosphorylation and signal transduction. Koo, P.H., Qiu, W.S. J. Biol. Chem. (1994)
- FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Ong, S.H., Guy, G.R., Hadari, Y.R., Laks, S., Gotoh, N., Schlessinger, J., Lax, I. Mol. Cell. Biol. (2000)
- Characterization of two neuroblastoma cell lines expressing recombinant nerve growth factor receptors. Reddy, U.R., Venkatakrishnan, G., Roy, A.K., Chen, J., Hardy, M., Mavilio, F., Rovera, G., Pleasure, D., Ross, A.H. J. Neurochem. (1991)
- The common neurotrophin receptor p75NTR enhances the ability of PC12 cells to resist oxidative stress by a trkA-dependent mechanism. Wang, W., Dow, K.E., Riopelle, R.J., Ross, G.M. Neurotoxicity research. (2001)
- Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor. Mardy, S., Miura, Y., Endo, F., Matsuda, I., Indo, Y. Hum. Mol. Genet. (2001)
- The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. Meakin, S.O., MacDonald, J.I., Gryz, E.A., Kubu, C.J., Verdi, J.M. J. Biol. Chem. (1999)
- Functional analysis of discoidin domain receptor 1: effect of adhesion on DDR1 phosphorylation. L'hôte, C.G., Thomas, P.H., Ganesan, T.S. FASEB J. (2002)
- Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3beta and stimulate axonal growth. Arevalo, M.A., Rodríguez-Tébar, A. Mol. Biol. Cell (2006)
- Expression of functional TrkA receptor tyrosine kinase in the HMC-1 human mast cell line and in human mast cells. Tam, S.Y., Tsai, M., Yamaguchi, M., Yano, K., Butterfield, J.H., Galli, S.J. Blood (1997)
- NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number. Woo, C.W., Lucarelli, E., Thiele, C.J. Oncogene (2004)
- FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling. Zheng, W.H., Kar, S., Quirion, R. J. Neurochem. (2002)
- Neurotrophic factors in relapsing remitting and secondary progressive multiple sclerosis patients during interferon beta therapy. Caggiula, M., Batocchi, A.P., Frisullo, G., Angelucci, F., Patanella, A.K., Sancricca, C., Nociti, V., Tonali, P.A., Mirabella, M. Clin. Immunol. (2006)
- Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. Nakamura, T., Komiya, M., Sone, K., Hirose, E., Gotoh, N., Morii, H., Ohta, Y., Mori, N. Mol. Cell. Biol. (2002)
- p75 and Trk: a two-receptor system. Chao, M.V., Hempstead, B.L. Trends Neurosci. (1995)
- Comparison of the biophysical characteristics of human brain-derived neurotrophic factor, neurotrophin-3, and nerve growth factor. Narhi, L.O., Rosenfeld, R., Talvenheimo, J., Prestrelski, S.J., Arakawa, T., Lary, J.W., Kolvenbach, C.G., Hecht, R., Boone, T., Miller, J.A. J. Biol. Chem. (1993)
- TrkA amino acids controlling specificity for nerve growth factor. O'Connell, L., Hongo, J.A., Presta, L.G., Tsoulfas, P. J. Biol. Chem. (2000)
- The RET and TRKA pathways collaborate to regulate neuroblastoma differentiation. Peterson, S., Bogenmann, E. Oncogene (2004)
- Comparative analysis of mouse-human hybrids with rearranged chromosomes 1 by in situ hybridization and Southern blotting: high-resolution mapping of NRAS, NGFB, and AMY on human chromosome 1. Münke, M., Lindgren, V., de Martinville, B., Francke, U. Somat. Cell Mol. Genet. (1984)
- Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Hallböök, F., Ibáñez, C.F., Persson, H. Neuron (1991)
- Chromosomal locations of the human and mouse genes for precursors of epidermal growth factor and the beta subunit of nerve growth factor. Zabel, B.U., Eddy, R.L., Lalley, P.A., Scott, J., Bell, G.I., Shows, T.B. Proc. Natl. Acad. Sci. U.S.A. (1985)