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Gene Review

Dlc1  -  deleted in liver cancer 1

Mus musculus

Synonyms: A730069N07Rik, Arhgap7, DLC-1, Deleted in liver cancer 1 protein homolog, HP, ...
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High impact information on Dlc1

  • A polymorphic microsatellite marker in intron 8 was used for mapping the gene (Arhgap7) to 20 cM on mouse chromosome 8 and for allelotyping of mouse liver tumor DNAs [1].
  • The hypusine residue is located at amino acid position 65 of the HP [2].

Analytical, diagnostic and therapeutic context of Dlc1

  • Some modest changes in the stratum corneum lipid transition temperature were induced by HP-beta-CyD and blue shifts were observed in the FTIR spectra of the C-H asymmetric and symmetric stretching of the lipids from the stratum corneum [3].
  • Differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM) have been used to determine the influence of beta-cyclodextrin (beta-CyD), hydroxypropyl-beta-CyD (HP-beta-CyD) and gamma-CyD on the structural properties of the stratum corneum from the hairless mouse [3].
  • Results from TEM studies indicated that HP-beta-CyD caused removal and possible disorganization of the lipid matrix that envelopes the corneocytes of the stratum corneum, whereas no effect was seen after treatment of the samples with beta-CyD and gamma-CyD [3].


  1. Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7). Durkin, M.E., Yuan, B.Z., Thorgeirsson, S.S., Popescu, N.C. Gene (2002) [Pubmed]
  2. cDNA and derived amino acid sequence of the hypusine containing protein from Dictyostelium discoideum. Sandholzer, U., Centea-Intemann, M., Noegel, A.A., Lottspeich, F. FEBS Lett. (1989) [Pubmed]
  3. Characterization of the influence of some cyclodextrins on the stratum corneum from the hairless mouse. Bentley, M.V., Vianna, R.F., Wilson, S., Collett, J.H. J. Pharm. Pharmacol. (1997) [Pubmed]
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