Gene Review:
DLC1 - DLC1 Rho GTPase activating protein
Homo sapiens
Synonyms:
ARHGAP7, DLC-1, Deleted in liver cancer 1 protein, HP, HP protein, ...
- Sequence variants of DLC1 in colorectal and ovarian tumours. Wilson, P.J., McGlinn, E., Marsh, A., Evans, T., Arnold, J., Wright, K., Biden, K., Young, J., Wainwright, B., Wicking, C., Chenevix-Trench, G. Hum. Mutat. (2000)
- Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study. Zheng, S.L., Mychaleckyj, J.C., Hawkins, G.A., Isaacs, S.D., Wiley, K.E., Turner, A., Chang, B.L., von Kap-Herr, C., Carpten, J.D., Pettenati, M., Bleecker, E.R., Walsh, P.C., Trent, J.M., Meyers, D.A., Isaacs, W.B., Xu, J. Mutat. Res. (2003)
- Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells. den Hollander, P., Kumar, R. Cancer Res. (2006)
- DLC1 is unlikely to be a primary target for deletions on chromosome arm 8p22 in head and neck squamous cell carcinoma. Hewitt, C., Wilson, P., McGlinn, E., MacFarlane, G., Papageorgiou, A., Woodwards, R.T., Sloan, P., Gollin, S.M., Paterson, I., Parkinson, K.K., Read, A.P., Thakker, N. Cancer Lett. (2004)
- The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Seng, T.J., Low, J.S., Li, H., Cui, Y., Goh, H.K., Wong, M.L., Srivastava, G., Sidransky, D., Califano, J., Steenbergen, R.D., Rha, S.Y., Tan, J., Hsieh, W.S., Ambinder, R.F., Lin, X., Chan, A.T., Tao, Q. Oncogene (2007)
- Circannual control of hibernation by HP complex in the brain. Kondo, N., Sekijima, T., Kondo, J., Takamatsu, N., Tohya, K., Ohtsu, T. Cell (2006)
- The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. Liao, Y.C., Si, L., Devere White, R.W., Lo, S.H. J. Cell Biol. (2007)
- I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. Crépieux, P., Kwon, H., Leclerc, N., Spencer, W., Richard, S., Lin, R., Hiscott, J. Mol. Cell. Biol. (1997)
- Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. Kim, T.Y., Jong, H.S., Song, S.H., Dimtchev, A., Jeong, S.J., Lee, J.W., Kim, T.Y., Kim, N.K., Jung, M., Bang, Y.J. Oncogene (2003)
- Bismuth subsalicylate instead of metronidazole with lansoprazole and clarithromycin for Helicobacter pylori infection: a randomized trial. Chey, W.D., Fisher, L., Elta, G.H., Barnett, J.L., Nostrant, T., DelValle, J., Hasler, W.L., Scheiman, J.M. Am. J. Gastroenterol. (1997)
- The use of hexazonium-p-rosanilin in the histochemical demonstration of peptidases. Lojda, Z. Histochemistry (1975)
- The 14-kDa dynein light chain-family protein Dlc1 is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. Miki, F., Okazaki, K., Shimanuki, M., Yamamoto, A., Hiraoka, Y., Niwa, O. Mol. Biol. Cell (2002)
- Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression. Yam, J.W., Ko, F.C., Chan, C.Y., Jin, D.Y., Ng, I.O. Cancer Res. (2006)
- Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. Rayala, S.K., den Hollander, P., Manavathi, B., Talukder, A.H., Song, C., Peng, S., Barnekow, A., Kremerskothen, J., Kumar, R. J. Biol. Chem. (2006)
- DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. Yuan, B.Z., Jefferson, A.M., Baldwin, K.T., Thorgeirsson, S.S., Popescu, N.C., Reynolds, S.H. Oncogene (2004)
- Dynein light chain 1 phosphorylation controls macropinocytosis. Yang, Z., Vadlamudi, R.K., Kumar, R. J. Biol. Chem. (2005)
- Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Vadlamudi, R.K., Bagheri-Yarmand, R., Yang, Z., Balasenthil, S., Nguyen, D., Sahin, A.A., den Hollander, P., Kumar, R. Cancer Cell (2004)
- DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. Scholz, R.P., Regner, J., Theil, A., Erlmann, P., Holeiter, G., Jähne, R., Schmid, S., Hausser, A., Olayioye, M.A. J. Cell. Sci. (2009)
- Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma. Wong, C.M., Yam, J.W., Ching, Y.P., Yau, T.O., Leung, T.H., Jin, D.Y., Ng, I.O. Cancer Res. (2005)
- Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma. Wong, C.M., Lee, J.M., Ching, Y.P., Jin, D.Y., Ng, I.O. Cancer Res. (2003)
- Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications. Guan, M., Zhou, X., Soulitzis, N., Spandidos, D.A., Popescu, N.C. Clin. Cancer Res. (2006)
- Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Yuan, B.Z., Miller, M.J., Keck, C.L., Zimonjic, D.B., Thorgeirsson, S.S., Popescu, N.C. Cancer Res. (1998)