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Gene Review

Dlc1  -  DLC1 Rho GTPase activating protein

Rattus norvegicus

Synonyms: Arhgap7, DLC-1, Deleted in liver cancer 1 protein homolog, Rho GTPase-activating protein 7, Rho-type GTPase-activating protein 7, ...
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Disease relevance of Dlc1

  • Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP [1].
  • Expression of higher levels of tGAP1 by infection of somatic cells with recombinant adenoviruses demonstrated that tGAP1 efficiently induces apoptosis, which to our knowledge is the first such demonstration for a RhoGAP protein [2].

High impact information on Dlc1

  • At its carboxy-terminal end, p190 contains a region that is conserved in the breakpoint cluster region, n-chimaerin, and Rho-GAP [3].
  • Strikingly, this shift in favor of nonpyramidal morphologies is also inhibited by the expression of dominant negative mutants of Cdc42 and Rac and by RhoGAP p190 [4].
  • This novel p122-RhoGAP binds to PLC-delta 1 and activates the phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolyzing activity of PLC-delta 1 [5].
  • Clustering of cortactin during podosome formation causes the rapid, local dispersion of myosin and tropomyosin, and interferes with the F-actin binding of h1calponin, consistent with a RhoGAP-mediated reduction of contractility [6].
  • Six cDNAs represent human homologs of genes known in other species, namely, mouse HSPE71, Rat RhoGAP protein, S cerevisiae leucyl tRNA synthetase and S cerevisiae chromosome II ORF YBLO44W [7].

Biological context of Dlc1

  • A novel testicular RhoGAP-domain protein induces apoptosis [2].
  • These findings define a pathway in which Fyn activity regulates the phosphorylation of p190, leading to an increase in RhoGAP activity with a subsequent increase in RhoGDP, which in turn, regulates the morphological changes that accompany oligodendrocyte differentiation [8].
  • CAMGAP1 is composed of an Src homology 3 (SH3) domain, multiple WW domains, a proline-rich region, a PH domain and a RhoGAP domain, and has the domain architecture similar to ARHGAP9 and ARHGAP12 [9].

Anatomical context of Dlc1

  • As Rho-GAP signaling had been shown to be influenced by p190 levels, leading to the disassembly of focal adhesion contacts and the loss of cytoskeletal architecture, we also measured the changes in Rho-GAP during prostate regression [10].
  • We isolated a novel RhoGAP domain-containing tGAP1 protein from male germ cells that exhibits unusual properties [2].
  • Oligophrenin-1 is a RhoGTPase-activating protein (RhoGAP) that is involved in the regulation of shape changes in dendritic spines, and outgrowth of axons and dendrites in the brain [11].

Associations of Dlc1 with chemical compounds


Other interactions of Dlc1


Analytical, diagnostic and therapeutic context of Dlc1

  • Ral-GAP also differed from Rho-GAP and Rap-GAP by virtue of its elution from a gel filtration column with proteins of Mr greater than 10(6) [13].


  1. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Yuan, B.Z., Miller, M.J., Keck, C.L., Zimonjic, D.B., Thorgeirsson, S.S., Popescu, N.C. Cancer Res. (1998) [Pubmed]
  2. A novel testicular RhoGAP-domain protein induces apoptosis. Modarressi, M.H., Cheng, M., Tarnasky, H.A., Lamarche-Vane, N., de Rooij, D.G., Ruan, Y., van der Hoorn, F.A. Biol. Reprod. (2004) [Pubmed]
  3. Association between GTPase activators for Rho and Ras families. Settleman, J., Albright, C.F., Foster, L.C., Weinberg, R.A. Nature (1992) [Pubmed]
  4. Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42. Threadgill, R., Bobb, K., Ghosh, A. Neuron (1997) [Pubmed]
  5. A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities. Homma, Y., Emori, Y. EMBO J. (1995) [Pubmed]
  6. Actin cytoskeleton remodelling via local inhibition of contractility at discrete microdomains. Burgstaller, G., Gimona, M. J. Cell. Sci. (2004) [Pubmed]
  7. Isolation of expressed sequences that include a gene for familial breast cancer (BRCA2) and other novel transcripts from a five megabase region on chromosome 13q12. Jacob, A.N., Kandpal, G., Kandpal, R.P. Oncogene (1996) [Pubmed]
  8. Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation. Wolf, R.M., Wilkes, J.J., Chao, M.V., Resh, M.D. J. Neurobiol. (2001) [Pubmed]
  9. Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. Sakakibara, T., Nemoto, Y., Nukiwa, T., Takeshima, H. FEBS Lett. (2004) [Pubmed]
  10. Expression of p190A during apoptosis in the regressing rat ventral prostate. Morrissey, C., Bennett, S., Nitsche, E., Guenette, R.S., Wong, P., Tenniswood, M. Endocrinology (1999) [Pubmed]
  11. Oligophrenin-1, a Rho GTPase-activating protein (RhoGAP) involved in X-linked mental retardation, is expressed in the enteric nervous system. Xiao, J., Neylon, C.B., Hunne, B., Furness, J.B. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2003) [Pubmed]
  12. Involvement of rho and rho-associated kinase in sphincteric smooth muscle contraction by angiotensin II. Rattan, S., Puri, R.N., Fan, Y.P. Exp. Biol. Med. (Maywood) (2003) [Pubmed]
  13. Characterization of a GTPase-activating protein for the Ras-related Ral protein. Emkey, R., Freedman, S., Feig, L.A. J. Biol. Chem. (1991) [Pubmed]
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