High impact information on Hpcal4

• These results suggest that NVP-2 and NVP-3 are additional members of the NVP gene family [1].
• The deduced amino acid sequences of NVP-2 and NVP-3 are 89.0% and 68.6% identical to that of NVP-1, respectively, and contain consensus sequences for EF-hand Ca(2+)-binding sites [1].
• Hippocalcin and neuronal visinin-like protein-2 are mainly expressed in the forebrain and have similar expression patterns (neocortex, hippocampus and caudate-putamen) [2].
• In most cell types, NVP2 immunoreactivity was located in the cytoplasm and plasma membrane of the cell bodies and dendrites [3].
• NVP2 levels in hippocampus and cerebral cortex decreased by approximately 30% at 24 months [4].

Biological context of Hpcal4

• In CA1 through CA3 and in dentate gyrus, NVP2-positive cell numbers were preserved, but staining intensity decreased [4].

Anatomical context of Hpcal4

• Visinin-like protein-2 (VILIP-2) is a CaM-related Ca2+-binding protein expressed in the neocortex and hippocampus [5].
• In cerebral cortex, the number and intensity of NVP2-positive cells decreased [4].

Physical interactions of Hpcal4

• The distribution of neural visinin-like Ca(2+)-binding protein 2 (NVP2) in adult rat brain was analyzed by immunoblot and immunohistochemical methods [3].

Other interactions of Hpcal4

• In contrast to CaBP1, coexpression of VILIP-2 slows inactivation in a Ca2+-independent manner, but this effect also requires myristoylation [6].

Analytical, diagnostic and therapeutic context of Hpcal4

• Northern blot analysis shows that NVP-1, NVP-2, and NVP-3 mRNAs are most highly expressed in brain and are differentially expressed in various regions of rat brain [1].

References