The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

PBX3  -  pre-B-cell leukemia homeobox 3

Homo sapiens

Synonyms: Homeobox protein PBX3, Pre-B-cell leukemia transcription factor 3
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on PBX3

  • When complexed with Hoxc-6, each of the Pbx gene products binds the same consensus sequence, TGATTTAT, which differs from the site bound by Pbx3 alone [1].
  • Among the Pbx proteins by themselves, only Pbx3 binds with high affinity, as a monomer or as a homodimer, to an optimal binding site, TGATTGATTTGAT [1].
  • Chromosome in situ hybridizations demonstrated that the PBX genes are not clustered but map to separate chromosomal loci: PBX1, 1q23; PBX2, 3q22-23; PBX3, 9q33-34 [2].
  • Similar to PBX1 RNA, PBX3 RNA is alternatively spliced to yield two translation products with different carboxy termini, a feature not observed for PBX2 [2].
  • PBX3 is a member of the PBX family of TALE homeobox genes [3].
 

Biological context of PBX3

References

  1. Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins. Neuteboom, S.T., Murre, C. Mol. Cell. Biol. (1997) [Pubmed]
  2. PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1. Monica, K., Galili, N., Nourse, J., Saltman, D., Cleary, M.L. Mol. Cell. Biol. (1991) [Pubmed]
  3. Novel alternative PBX3 isoforms in leukemia cells with distinct interaction specificities. Milech, N., Kees, U.R., Watt, P.M. Genes Chromosomes Cancer (2001) [Pubmed]
  4. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias. LeBrun, D.P., Cleary, M.L. Oncogene (1994) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities