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ALAD  -  aminolevulinate dehydratase

Bos taurus

 
 
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High impact information on ALAD

  • Kinetic analysis of both brain and liver ALAD activity at an IC50 Pb showed a "mixed" or noncompetitive inhibition pattern [1].
  • This study was undertaken to examine the relative sensitivity of brain and liver ALAD to Pb inhibition in vitro and to determine if inhibition of hepatic ALAD by Pb could be reversed by addition of partially purified brain PbBP to liver cytosol [1].
  • Differences between the groups were highly significant for blood lead (PbB) content, activity of erythrocyte delta-aminolevulinic acid dehydratase (ALAD) and erythrocyte protoporphyrin (EP) content, but considerably less significant for blood hemoglobin (Hb) content and not significant for hematocrit (Hct) [2].
  • Within 7 days after Pb administration ceased, ALAD did not increase significantly, even when calves were given calcium ethylenediaminetetraacetic acid (CaNa2EDTA); however, blood Pb concentration decreased by 50% [3].
  • 5-Aminolevulinic acid dehydratase (ALAD) from bovine liver contains zinc that is partially lost during the isolation of the enzyme [4].
 

Biological context of ALAD

  • The mechanism of enzyme activation, as demonstrated using 65Zn-labeled thionein, involves direct transfer of Zn from Zn-thionein to ALAD [5].
 

Anatomical context of ALAD

  • This study was undertaken to evaluate further the differences in sensitivity of renal and hepatic ALAD to Pb and to determine if inhibition of hepatic ALAD by Pb could be reversed by addition of partially purified PbBP from kidney to liver cytosol [6].
  • Results indicated that ALAD of normal bovine erythrocytes increased 2- to 3-fold from 1 week to 9 weeks of age and then slowly returned to the initial (1 week old) value by 9 months of age [3].
 

Associations of ALAD with chemical compounds

 

Analytical, diagnostic and therapeutic context of ALAD

  • Gel filtration of incubates containing 203Pb demonstrated that the presence of Zn-thionein alters the cytosolic binding pattern of Pb, with less bound to ALAD and more bound to Zn-thionein [7].

References

 
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