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Alad  -  aminolevulinate, delta-, dehydratase

Mus musculus

Synonyms: ALADH, Delta-aminolevulinic acid dehydratase, Lv, Porphobilinogen synthase
 
 
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Disease relevance of Alad

 

High impact information on Alad

  • A parsimony tree analysis of three D/Lv sequences with a set of class I gene sequences revealed that the H-2v sequences clustered with D region genes [3].
  • Purification of a 38-kDa protein from rabbit reticulocyte lysate which promotes protein renaturation by heat shock protein 70 and its identification as delta-aminolevulinic acid dehydratase and as a putative DnaJ protein [4].
  • The best associations were those between the regions near the Lv locus on chromosome 4 and the Tnfr1 locus on chromosome 6 [5].
  • No recombinants were identified in 124 animals between Lv and Orm-1 [6].
  • Hxb was found to be 1.6 cM distal to Lv and Orm-1, and 4.8 cM proximal to Tyrp-1, or b [6].
 

Biological context of Alad

 

Anatomical context of Alad

  • Analyses of delta-aminolevulinic acid dehydratase activity and protoporphyrin levels in erythrocytes among three different species [9].
 

Associations of Alad with chemical compounds

 

Other interactions of Alad

References

  1. Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone. Sassa, S., Kappas, A. J. Clin. Invest. (1983) [Pubmed]
  2. Induction of delta-aminolevulinic acid dehydratase in mouse Friend virus-transformed erythroleukemia cells during erythroid differentiation. Chang, C.S., Sassa, S. Blood (1984) [Pubmed]
  3. Structural and functional analysis of three D/L-like class I molecules from H-2v: indications of an ancestral family of D/L genes. Cai, Z., Pease, L.R. J. Exp. Med. (1992) [Pubmed]
  4. Purification of a 38-kDa protein from rabbit reticulocyte lysate which promotes protein renaturation by heat shock protein 70 and its identification as delta-aminolevulinic acid dehydratase and as a putative DnaJ protein. Gross, M., Hessefort, S., Olin, A. J. Biol. Chem. (1999) [Pubmed]
  5. Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice. Fierer, J., Walls, L., Wright, F., Kirkland, T.N. Infect. Immun. (1999) [Pubmed]
  6. Comparative mapping of mouse chromosome 4 and human chromosome 9: Lv, Orm, and Hxb are closely linked on mouse chromosome 4. Pilz, A., Moseley, H., Peters, J., Abbott, C. Mamm. Genome (1992) [Pubmed]
  7. Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme content and delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Ebert, P.S., Hess, R.A., Frykholm, B.C., Tschudy, D.P. Biochem. Biophys. Res. Commun. (1979) [Pubmed]
  8. Efficacy of 2,3-dimercapto-1-propanesulfonic acid (DMPS) and diphenyl diselenide on cadmium induced testicular damage in mice. Santos, F.W., Zeni, G., Rocha, J.B., do Nascimento, P.C., Marques, M.S., Nogueira, C.W. Food Chem. Toxicol. (2005) [Pubmed]
  9. Analyses of delta-aminolevulinic acid dehydratase activity and protoporphyrin levels in erythrocytes among three different species. Murayama, F., Nonaka, S., Ohgami, T., Yoshida, H. J. Dermatol. (1986) [Pubmed]
  10. Effects of individual and combined exposure to sodium arsenite and sodium fluoride on tissue oxidative stress, arsenic and fluoride levels in male mice. Mittal, M., Flora, S.J. Chem. Biol. Interact. (2006) [Pubmed]
  11. Beneficial effects of S-adenosyl-L-methionine on aminolevulinic acid dehydratase, glutathione, and lipid peroxidation during acute lead-ethanol administration in mice. Flora, G.J., Seth, P.K. Alcohol (1999) [Pubmed]
  12. Profile of nonprotein thiols, lipid peroxidation and delta-aminolevulinate dehydratase activity in mouse kidney and liver in response to acute exposure to mercuric chloride and sodium selenite. Farina, M., Brandão, R., de Lara, F.S., Pagliosa, L.B., Soares, F.A., Souza, D.O., Rocha, J.B. Toxicology (2003) [Pubmed]
  13. Distribution of delta-aminolevulinic acid synthetase and delta-aminolevulinic acid dehydratase in liver and kidney of rainbow trout (Salmo gairdnerii). Addison, R.F., Fitzpatrick, D., Renton, K.W. Comp. Biochem. Physiol., B (1990) [Pubmed]
  14. Linkage of the structural gene for uroporphyrinogen I synthase to markers on mouse chromosome 9 in a cross between feral and inbred mice. Antonucci, T.K., Chapman, V.C., Meisler, M.H. Biochem. Genet. (1982) [Pubmed]
  15. Effect of lead exposure on some biological indices related to porphyrin metabolism and the activity of erythrocyte pyrimidine 5'-nucleotidase in the mice. Tomokuni, K., Ichiba, M., Hirai, Y. Arch. Toxicol. (1989) [Pubmed]
  16. Studies on the inhibition of erythrocyte and hepatic delta-aminolevulinic acid dehydratase activities and its restoration in mice exposed to lead. Koga, N., Hirai, Y., Hasegawa, T., Tomokuni, K. Industrial health. (1984) [Pubmed]
  17. Trichloroethylene toxicity in mice: a biochemical, hematological and pathological assessment. Goel, S.K., Rao, G.S., Pandya, K.P., Shanker, R. Indian J. Exp. Biol. (1992) [Pubmed]
  18. Cyanide intoxication--III. On the analogous and different effects provoked by non-lethal and lethal challenged doses. Buzaleh, A.M., Vazquez, E.S., del Carmen Batlle, A.M. Gen. Pharmacol. (1990) [Pubmed]
 
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