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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ANKMY1  -  ankyrin repeat and MYND domain containing 1

Homo sapiens

Synonyms: Ankyrin repeat and MYND domain-containing protein 1, FLJ20499, TSAL1, Testis-specific ankyrin-like protein 1, ZMYND13, ...
 
 
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Psychiatry related information on ANKMY1

  • Different dietary habits of the !Kung lead to significant differences in their sex hormone status: both levels of Tsal and the androgen ratio Tsal/Tser decrease with increasing supplement of the traditional hunter-gatherer diet with domestic and Western food products [1].
 

High impact information on ANKMY1

  • Here we demonstrate that saliva induces strong humoral responses against the major 43-45 kDa protein fraction (tsetse salivary gland proteins 1 and 2 - Tsal1 and Tsal2) in mice and humans and suppresses murine T and B cell responses to heterologous antigen [2].
  • Here, we report on the molecular aspects of three different cDNAs and their putative products expressed in salivary glands: cDNAs TAg5, Tsal1 and Tsal2 [3].
  • A reverse transcription polymerase chain reaction based amplification approach indicates that TAg5 transcipts can be detected from proventriculus and midgut tissues of the fly in addition to salivary glands, while Tsal1 and Tsal2 expression is restricted to salivary gland and proventriculus [3].
  • Tsal, the bioavailable fraction of total testosterone, exerts a weak positive influence on the degree of arm and leg hair growth; the most significant positive effect on the growth of abdominal, arm, and leg hair in our samples is caused by E2 [4].
  • Serum concentrations of testosterone (Tser), 5 alpha-dihydrotestosterone (DHT), estradiol 17 beta (E2), and free testosterone in saliva (Tsal) were determined by means of the radioimmunoassay method in 114 !Kung San men living in the Bushmanland district of Namibia [1].
 

Associations of ANKMY1 with chemical compounds

  • For all samples of all subjects, psychic stress correlates positively with the ratio of Tsal/Tser [5].
  • Serum concentrations of testosterone (Tser), 5 alpha-dihydrotestosterone (DHT), and free testosterone (Tsal) in saliva were determined in 117 healthy young men between the ages of 20 and 30 [6].
  • Most of the individual measurements as well as the resulting factor scores correlated significantly with the sex hormone variables and the hormone ratios Tser/DHT, Tsal/Tser, and Tser/E2 in the !Kung San and the two Kavango samples [7].

References

  1. Serum and saliva sex hormone levels in !Kung San men. Christiansen, K.H. Am. J. Phys. Anthropol. (1991) [Pubmed]
  2. Tsetse fly saliva biases the immune response to Th2 and induces anti-vector antibodies that are a useful tool for exposure assessment. Caljon, G., Van Den Abbeele, J., Sternberg, J.M., Coosemans, M., De Baetselier, P., Magez, S. Int. J. Parasitol. (2006) [Pubmed]
  3. Characterization of genes expressed in the salivary glands of the tsetse fly, Glossina morsitans morsitans. Li, S., Kwon, J., Aksoy, S. Insect Mol. Biol. (2001) [Pubmed]
  4. Sex hormone levels and body hair growth in !Kung San and Kavango men from Namibia. Winkler, E.M., Christiansen, K. Am. J. Phys. Anthropol. (1993) [Pubmed]
  5. Sex hormones and stress in the human male. Christiansen, K., Knussmann, R., Couwenbergs, C. Hormones and behavior. (1985) [Pubmed]
  6. Androgen levels and components of aggressive behavior in men. Christiansen, K., Knussmann, R. Hormones and behavior. (1987) [Pubmed]
  7. Anthropometric-hormonal correlation patterns in San and Kavango males from Namibia. Winkler, E.M., Christiansen, K. Ann. Hum. Biol. (1991) [Pubmed]
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