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Gene Review

NME8  -  NME/NM23 family member 8

Homo sapiens

Synonyms: CILD6, NM23-H8, SPTRX2, Spermatid-specific thioredoxin-2, Sptrx-2, ...
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Disease relevance of TXNDC3

  • CONCLUSIONS: The sperm specific expression of Sptrx-2, together with its chromosomal assignment to a position reported as a potential locus for flagellar anomalies and male infertility phenotypes such as primary ciliary dyskinesia, suggests that it might be a novel component of the human sperm axonemal organization [1].

High impact information on TXNDC3


Biological context of TXNDC3

  • The Sptrx-2 ORF (open reading frame) encodes for a protein of 588 amino acids with two different domains: an N-terminal thioredoxin domain encompassing the first 105 residues and a C-terminal domain composed of three repeats of a NDP kinase domain [1].

Associations of TXNDC3 with chemical compounds

  • A large part of the C-terminal glutamic acid-rich region present in sea urchin IC1 was greatly reduced in C. intestinalis IC3 and completely lost in human NM23-H8 [3].

Other interactions of TXNDC3

  • RESULTS: We report here the identification and characterization of a novel member of the thioredoxin family, the second with a tissue-specific distribution in human sperm, termed Sptrx-2 [1].


  1. Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells. Sadek, C.M., Damdimopoulos, A.E., Pelto-Huikko, M., Gustafsson, J.A., Spyrou, G., Miranda-Vizuete, A. Genes Cells (2001) [Pubmed]
  2. Cis- and trans-acting gene regulation is associated with osteoarthritis. Mahr, S., Burmester, G.R., Hilke, D., Gobel, U., Grutzkau, A., Haupl, T., Hauschild, M., Koczan, D., Krenn, V., Neidel, J., Perka, C., Radbruch, A., Thiesen, H.J., Muller, B. Am. J. Hum. Genet. (2006) [Pubmed]
  3. Molecular cloning and characterization of a thioredoxin/nucleoside diphosphate kinase related dynein intermediate chain from the ascidian, Ciona intestinalis. Padma, P., Hozumi, A., Ogawa, K., Inaba, K. Gene (2001) [Pubmed]
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