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Gene Review

NME2P1  -  NME/NM23 nucleoside diphosphate kinase 2...

Homo sapiens

Synonyms: NDK, NDP kinase
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Disease relevance of NME2P1


High impact information on NME2P1

  • The relative staining intensities were evaluated by comparing primary tumor sites with adjacent nontumorous liver tissue or with metastatic sites, RESULTS: The expression of NDP kinase in primary sites in patients with distant metastases was significantly less intense than that in patients without distant metastases (P = .018) [6].
  • CONCLUSION: These results suggest that the reduced expression of NDP kinase is closely associated with distant metastatic potential in hepatocellular carcinoma [6].
  • The intensity of NDP kinase expression did not statistically correlate with tumor size or number of lesions in the liver, histopathological classification of tumor, associated liver diseases, hepatitis virus markers, or tumor markers [6].
  • Involvement of NM23/NDP kinase in a DNA repair pathway would be consistent with its role in normal and tumor cell development [7].
  • Catalysis of DNA cleavage and nucleoside triphosphate synthesis by NM23-H2/NDP kinase share an active site that implies a DNA repair function [7].

Chemical compound and disease context of NME2P1

  • Meanwhile, all of the recombinant mutant Nm23-H1 proteins produced in Escherichia coli exhibited NDP kinase activity levels at the wild type protein, although the P96S and S120G mutant proteins exhibited decreased histidine protein kinase activity and autophosphorylation level, respectively [8].
  • Under the same experimental conditions, the anti-herpetic (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) derivative was efficiently converted to BVDU-MP and BVDU-DP by both VZV TK and HSV-1 TK and further, into BVDU-TP, by NDP kinase [9].
  • To contribute to the studies for the development of a universal vaccine, the occurrence of antibodies (Ab) against three HIV-1 strains (MN, BRU and NDK) was determined in serum samples from 85 HIV-1-positive patients, adult volunteers seen at the University Hospital of the Faculty of Medicine of Ribeirão Preto-USP [10].

Biological context of NME2P1


Anatomical context of NME2P1


Associations of NME2P1 with chemical compounds

  • Our results reveal that there are no significant changes between the two enzyme versions even in the surroundings of the catalytic histidine that is required for NDP kinase activity [17].
  • Several biochemical activities have been reported for Nm23, including NDP kinase activity, serine autophosphorylation and protein-histidine kinase activity [18].
  • Moreover, no correlation was observed between NDP-kinase activity and tumor size, histoprognostic index, estrogen receptors or progesterone receptors [2].
  • NDP kinase CDelta had similar kinetic properties to the major human NDP kinases A and B, but was significantly more stable to denaturation by urea and heat [19].
  • Overnight incubation of formalin-fixed tumor sections at 4 degree C with primary rabbit polyclonal IgG antibody to human nm23-H1/NDP kinase was followed by detection with standard ABC method [20].

Regulatory relationships of NME2P1


Other interactions of NME2P1


Analytical, diagnostic and therapeutic context of NME2P1


  1. Mutational analysis of NM23-H2/NDP kinase identifies the structural domains critical to recognition of a c-myc regulatory element. Postel, E.H., Weiss, V.H., Beneken, J., Kirtane, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Nucleoside diphosphate kinase/NM23 expression in breast cancer: lack of correlation with lymph-node metastasis. Sastre-Garau, X., Lacombe, M.L., Jouve, M., Véron, M., Magdelénat, H. Int. J. Cancer (1992) [Pubmed]
  3. Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues. Yoon, J.H., Singh, P., Lee, D.H., Qiu, J., Cai, S., O'Connor, T.R., Chen, Y., Shen, B., Pfeifer, G.P. Biochemistry (2005) [Pubmed]
  4. Immunohistochemical analysis of nucleoside diphosphate kinases in oral squamous cell carcinomas. Otsuki, K., Alcalde, R.E., Matsumura, T., Kimura, N. Oncology (1997) [Pubmed]
  5. Immunohistochemical analysis of nm23/NDP kinase expression in human lung adenocarcinoma: association with tumor progression in Clara cell type. Ozeki, Y., Takishima, K., Mamiya, G. Jpn. J. Cancer Res. (1994) [Pubmed]
  6. Expression in human hepatocellular carcinoma of nucleoside diphosphate kinase, a homologue of the nm23 gene product. Nakayama, T., Ohtsuru, A., Nakao, K., Shima, M., Nakata, K., Watanabe, K., Ishii, N., Kimura, N., Nagataki, S. J. Natl. Cancer Inst. (1992) [Pubmed]
  7. Catalysis of DNA cleavage and nucleoside triphosphate synthesis by NM23-H2/NDP kinase share an active site that implies a DNA repair function. Postel, E.H., Abramczyk, B.M., Levit, M.N., Kyin, S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  8. Point mutations affecting the oligomeric structure of Nm23-H1 abrogates its inhibitory activity on colonization and invasion of prostate cancer cells. Kim, Y.I., Park, S., Jeoung, D.I., Lee, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  9. Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. Sienaert, R., Naesens, L., Brancale, A., De Clercq, E., McGuigan, C., Balzarini, J. Mol. Pharmacol. (2002) [Pubmed]
  10. Neutralizing antibodies in Brazilian sera against three strains of human immunodeficiency virus type 1 (HIV-1). Machado, A.A., Hirsch, I., Figueiredo, J.F., Martinez, R., Chermann, J.C. Rev. Inst. Med. Trop. Sao Paulo (1997) [Pubmed]
  11. Nm23/NDP kinases in human male germ cells: role in spermiogenesis and sperm motility? Munier, A., Serres, C., Kann, M.L., Boissan, M., Lesaffre, C., Capeau, J., Fouquet, J.P., Lacombe, M.L. Exp. Cell Res. (2003) [Pubmed]
  12. Human NM23/nucleoside diphosphate kinase regulates gene expression through DNA binding to nuclease-hypersensitive transcriptional elements. Postel, E.H., Berberich, S.J., Rooney, J.W., Kaetzel, D.M. J. Bioenerg. Biomembr. (2000) [Pubmed]
  13. Discrimination between acid and alkali-labile phosphorylated residues on Immobilon: phosphorylation studies of nucleoside diphosphate kinase. Biondi, R.M., Walz, K., Issinger, O.G., Engel, M., Passeron, S. Anal. Biochem. (1996) [Pubmed]
  14. Expression of nm23/NDP kinase proteins on the cell surface. Urano, T., Furukawa, K., Shiku, H. Oncogene (1993) [Pubmed]
  15. The nucleoside diphosphate kinase of human neutrophils. Guignard, F., Markert, M. Biochem. J. (1996) [Pubmed]
  16. Immunohistochemical analysis of expression of nm23-H1/nucleoside diphosphate kinase in human thyroid carcinomas: lack of correlation between its expression and lymph node metastasis. Luo, W., Matsuo, K., Nagayama, Y., Urano, T., Furukawa, K., Takeshita, A., Nakayama, T., Yokoyama, N., Yamashita, S., Izumi, M. Thyroid (1993) [Pubmed]
  17. Crystal Structures of S120G Mutant and Wild Type of Human Nucleoside Diphosphate Kinase A in Complex with ADP. Giraud, M.F., Georgescauld, F., Lascu, I., Dautant, A. J. Bioenerg. Biomembr. (2006) [Pubmed]
  18. Nm23 and tumour metastasis: basic and translational advances. Freije, J.M., MacDonald, N.J., Steeg, P.S. Biochem. Soc. Symp. (1998) [Pubmed]
  19. Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene. Erent, M., Gonin, P., Cherfils, J., Tissier, P., Raschellà, G., Giartosio, A., Agou, F., Sarger, C., Lacombe, M.L., Konrad, M., Lascu, I. Eur. J. Biochem. (2001) [Pubmed]
  20. Elevated nm23 protein expression is correlated with diminished progression-free survival in patients with epithelial ovarian carcinoma. Srivatsa, P.J., Cliby, W.A., Keeney, G.L., Dodson, M.K., Suman, V.J., Roche, P.C., Podratz, K.C. Gynecol. Oncol. (1996) [Pubmed]
  21. Inhibitory action of nm23 proteins on induction of erythroid differentiation of human leukemia cells. Okabe-Kado, J., Kasukabe, T., Baba, H., Urano, T., Shiku, H., Honma, Y. Biochim. Biophys. Acta (1995) [Pubmed]
  22. New insights into Nm23 control of cell adhesion and migration. Fournier, H.N., Albigès-Rizo, C., Block, M.R. J. Bioenerg. Biomembr. (2003) [Pubmed]
  23. The crystal structure of a human nucleoside diphosphate kinase, NM23-H2. Webb, P.A., Perisic, O., Mendola, C.E., Backer, J.M., Williams, R.L. J. Mol. Biol. (1995) [Pubmed]
  24. A 16-kDa protein functions as a new regulatory protein for Hsc70 molecular chaperone and is identified as a member of the Nm23/nucleoside diphosphate kinase family. Leung, S.M., Hightower, L.E. J. Biol. Chem. (1997) [Pubmed]
  25. Localization of a second NM23 gene, NME2, to chromosome 17q21-q22. Kelsell, D.P., Black, D.M., Solomon, E., Spurr, N.K. Genomics (1993) [Pubmed]
  26. Quaternary structural analysis of nucleoside diphosphate kinases using capillary electrophoresis. Heo, Y.J., Kim, S.Y., Kim, E., Lee, K.J. Journal of chromatography. A. (1997) [Pubmed]
  27. Regulation of cellular functions by nucleoside diphosphate kinases in mammals. Kimura, N., Shimada, N., Fukuda, M., Ishijima, Y., Miyazaki, H., Ishii, A., Takagi, Y., Ishikawa, N. J. Bioenerg. Biomembr. (2000) [Pubmed]
  28. Nm23/nucleoside diphosphate kinase in human cancers. Hartsough, M.T., Steeg, P.S. J. Bioenerg. Biomembr. (2000) [Pubmed]
  29. Nucleoside diphosphate kinase from haloalkaliphilic archaeon Natronobacterium magadii: purification and characterization. Polosina YYu, n.u.l.l., Jarrell, K.F., Fedorov, O.V., Kostyukova, A.S. Extremophiles (1998) [Pubmed]
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