Disease relevance of ANGPT4

• Ang3 and Ang4 both produced potent corneal angiogenesis extending from the limbus across the mouse cornea in vivo [1].
• Irradiation at any dose did not affect the cellular protein levels of any of the angiopoietins, whereas hypoxia led to increasing levels of both angiopoietin-4 and angiopoietin-2 [2].

High impact information on ANGPT4

• In RPTE cells, angiopoietin-4 (Ang-4) expression was selectively induced by hypoxia or by expression of a hybrid form of HIF-1alpha [3].
• Furthermore, the diacetyl activity in water was overall not modified increasing only at high concentrations of AGP4 [4].
• 1-Hexanol exhibited retention in water with four fractions in the strength order AGP0 > dRG-II > mRG-II > AGP4 but was strongly salted out in the presence of fraction MP0 [4].
• Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure [5].
• Biological characterization of angiopoietin-3 and angiopoietin-4 [1].

Biological context of ANGPT4

• Recombinant Ang-4 protein protected endothelial cells against serum starvation-induced apoptosis and increased cultured endothelial cell migration and tube formation [6].
• Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping [7].

Anatomical context of ANGPT4

• We examined the biological effect of recombinant Ang3 and Ang4 proteins in primary cultured endothelial cells and in vivo in mice [1].

Other interactions of ANGPT4

• Ang-4 can function similarly as Ang-1 and substitute for Ang-1 to participate in hypoxia-induced angiogenesis [6].

References