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Gene Review

ANGPT4  -  angiopoietin 4

Homo sapiens

Synonyms: AGP4, ANG-3, ANG-4, ANG3, ANG4, ...
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Disease relevance of ANGPT4


High impact information on ANGPT4

  • In RPTE cells, angiopoietin-4 (Ang-4) expression was selectively induced by hypoxia or by expression of a hybrid form of HIF-1alpha [3].
  • Furthermore, the diacetyl activity in water was overall not modified increasing only at high concentrations of AGP4 [4].
  • 1-Hexanol exhibited retention in water with four fractions in the strength order AGP0 > dRG-II > mRG-II > AGP4 but was strongly salted out in the presence of fraction MP0 [4].
  • Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure [5].
  • Biological characterization of angiopoietin-3 and angiopoietin-4 [1].

Biological context of ANGPT4


Anatomical context of ANGPT4

  • We examined the biological effect of recombinant Ang3 and Ang4 proteins in primary cultured endothelial cells and in vivo in mice [1].

Other interactions of ANGPT4

  • Ang-4 can function similarly as Ang-1 and substitute for Ang-1 to participate in hypoxia-induced angiogenesis [6].


  1. Biological characterization of angiopoietin-3 and angiopoietin-4. Lee, H.J., Cho, C.H., Hwang, S.J., Choi, H.H., Kim, K.T., Ahn, S.Y., Kim, J.H., Oh, J.L., Lee, G.M., Koh, G.Y. FASEB J. (2004) [Pubmed]
  2. Differential regulation of VEGF, HIF1alpha and angiopoietin-1, -2 and -4 by hypoxia and ionizing radiation in human glioblastoma. Lund, E.L., Høg, A., Olsen, M.W., Hansen, L.T., Engelholm, S.A., Kristjansen, P.E. Int. J. Cancer (2004) [Pubmed]
  3. Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. Yamakawa, M., Liu, L.X., Belanger, A.J., Date, T., Kuriyama, T., Goldberg, M.A., Cheng, S.H., Gregory, R.J., Jiang, C. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
  4. Influence of wine structurally different polysaccharides on the volatility of aroma substances in a model system. Dufour, C., Bayonove, C.L. J. Agric. Food Chem. (1999) [Pubmed]
  5. Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure. Olsen, M.W., Ley, C.D., Junker, N., Hansen, A.J., Lund, E.L., Kristjansen, P.E. Neoplasia (2006) [Pubmed]
  6. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Yamakawa, M., Liu, L.X., Date, T., Belanger, A.J., Vincent, K.A., Akita, G.Y., Kuriyama, T., Cheng, S.H., Gregory, R.J., Jiang, C. Circ. Res. (2003) [Pubmed]
  7. Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping. Grosios, K., Leek, J.P., Markham, A.F., Yancopoulos, G.D., Jones, P.F. Cytogenet. Cell Genet. (1999) [Pubmed]
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