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Gene Review

ANGPT2  -  angiopoietin 2

Homo sapiens

Synonyms: AGPT2, ANG-2, ANG2, Ang2, Angiopoietin-2
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Disease relevance of ANGPT2


High impact information on ANGPT2


Chemical compound and disease context of ANGPT2


Biological context of ANGPT2


Anatomical context of ANGPT2


Associations of ANGPT2 with chemical compounds


Physical interactions of ANGPT2

  • Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition [28].

Regulatory relationships of ANGPT2


Other interactions of ANGPT2

  • Western blot analysis suggested that expression of Ang-1, Ang-2, Tie-2, and VEGF may be regulated at a transcriptional level [2].
  • Although the function of Tie2 and its ligands in tumor angiogenesis remains a subject of speculation, our findings are in agreement with a recently proposed hypothesis that in the presence of VEGF, local production of Ang-2 might promote angiogenesis [4].
  • Intensive multifactorial intervention is associated with reductions in plasma VEGF, vWf, and (in patients without CVD) Ang-2 levels, possibly reflecting an improved vascular profile with treatment [34].
  • Consistent with the expression of Angio2 in neovessels of advanced lesions a transcriptionally active STAT5 was detected [31].
  • Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region [35].

Analytical, diagnostic and therapeutic context of ANGPT2


  1. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Kelly, B.D., Hackett, S.F., Hirota, K., Oshima, Y., Cai, Z., Berg-Dixon, S., Rowan, A., Yan, Z., Campochiaro, P.A., Semenza, G.L. Circ. Res. (2003) [Pubmed]
  2. Hepatic expression of ANG2 RNA in metastatic colorectal cancer. Ogawa, M., Yamamoto, H., Nagano, H., Miyake, Y., Sugita, Y., Hata, T., Kim, B.N., Ngan, C.Y., Damdinsuren, B., Ikenaga, M., Ikeda, M., Ohue, M., Nakamori, S., Sekimoto, M., Sakon, M., Matsuura, N., Monden, M. Hepatology (2004) [Pubmed]
  3. Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival. Loges, S., Heil, G., Bruweleit, M., Schoder, V., Butzal, M., Fischer, U., Gehling, U.M., Schuch, G., Hossfeld, D.K., Fiedler, W. J. Clin. Oncol. (2005) [Pubmed]
  4. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Stratmann, A., Risau, W., Plate, K.H. Am. J. Pathol. (1998) [Pubmed]
  5. Human epidermal growth factor receptor 2 regulates angiopoietin-2 expression in breast cancer via AKT and mitogen-activated protein kinase pathways. Niu, G., Carter, W.B. Cancer Res. (2007) [Pubmed]
  6. Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. Murdoch, C., Tazzyman, S., Webster, S., Lewis, C.E. J. Immunol. (2007) [Pubmed]
  7. Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. Lewis, C.E., De Palma, M., Naldini, L. Cancer Res. (2007) [Pubmed]
  8. Angiopoietin-2 promotes disease progression of neuroendocrine tumors. Detjen, K.M., Rieke, S., Deters, A., Schulz, P., Rexin, A., Vollmer, S., Hauff, P., Wiedenmann, B., Pavel, M., Scholz, A. Clin. Cancer Res. (2010) [Pubmed]
  9. Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription. Yao, D., Taguchi, T., Matsumura, T., Pestell, R., Edelstein, D., Giardino, I., Suske, G., Ahmed, N., Thornalley, P.J., Sarthy, V.P., Hammes, H.P., Brownlee, M. Cell (2007) [Pubmed]
  10. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Wang, H.W., Trotter, M.W., Lagos, D., Bourboulia, D., Henderson, S., Mäkinen, T., Elliman, S., Flanagan, A.M., Alitalo, K., Boshoff, C. Nat. Genet. (2004) [Pubmed]
  11. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Bhandari, V., Choo-Wing, R., Lee, C.G., Zhu, Z., Nedrelow, J.H., Chupp, G.L., Zhang, X., Matthay, M.A., Ware, L.B., Homer, R.J., Lee, P.J., Geick, A., de Fougerolles, A.R., Elias, J.A. Nat. Med. (2006) [Pubmed]
  12. Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Daly, C., Wong, V., Burova, E., Wei, Y., Zabski, S., Griffiths, J., Lai, K.M., Lin, H.C., Ioffe, E., Yancopoulos, G.D., Rudge, J.S. Genes Dev. (2004) [Pubmed]
  13. Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer. Hata, K., Udagawa, J., Fujiwaki, R., Nakayama, K., Otani, H., Miyazaki, K. Oncology (2002) [Pubmed]
  14. Plasma vascular endothelial growth factor, angiopoietin-2, and soluble angiopoietin receptor tie-2 in diabetic retinopathy: effects of laser photocoagulation and angiotensin receptor blockade. Lip, P.L., Chatterjee, S., Caine, G.J., Hope-Ross, M., Gibson, J., Blann, A.D., Lip, G.Y. The British journal of ophthalmology. (2004) [Pubmed]
  15. A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia. Paradis, V., Bièche, I., Dargère, D., Laurendeau, I., Nectoux, J., Degott, C., Belghiti, J., Vidaud, M., Bedossa, P. Gastroenterology (2003) [Pubmed]
  16. Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Mandriota, S.J., Pyke, C., Di Sanza, C., Quinodoz, P., Pittet, B., Pepper, M.S. Am. J. Pathol. (2000) [Pubmed]
  17. Effects of angiogenic factor overexpression by human and rodent cholangiocytes in polycystic liver diseases. Fabris, L., Cadamuro, M., Fiorotto, R., Roskams, T., Spirlì, C., Melero, S., Sonzogni, A., Joplin, R.E., Okolicsanyi, L., Strazzabosco, M. Hepatology (2006) [Pubmed]
  18. Down-regulation of angiopoietin-1 expression in menorrhagia. Hewett, P., Nijjar, S., Shams, M., Morgan, S., Gupta, J., Ahmed, A. Am. J. Pathol. (2002) [Pubmed]
  19. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Kim, I., Kim, J.H., Moon, S.O., Kwak, H.J., Kim, N.G., Koh, G.Y. Oncogene (2000) [Pubmed]
  20. Signaling and regulation of endothelial cell survival by angiopoietin-2. Harfouche, R., Hussain, S.N. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  21. The regulation and localization of angiopoietin-1, -2, and their receptor Tie2 in normal and pathologic human placentae. Zhang, E.G., Smith, S.K., Baker, P.N., Charnock-Jones, D.S. Mol. Med. (2001) [Pubmed]
  22. Expression of angiopoietin 1 and 2 in ectopic endometrium on the chicken chorioallantoic membrane. Drenkhahn, M., Gescher, D.M., Wolber, E.M., Meyhoefer-Malik, A., Malik, E. Fertil. Steril. (2004) [Pubmed]
  23. Vascular endothelial growth factor and angiopoietin are required for prostate regeneration. Wang, G.M., Kovalenko, B., Huang, Y., Moscatelli, D. Prostate (2007) [Pubmed]
  24. Vascular endothelial growth factor (VEGF) and angiopoietin regulation by gonadotrophin and steroids in macaque granulosa cells during the peri-ovulatory interval. Hazzard, T.M., Molskness, T.A., Chaffin, C.L., Stouffer, R.L. Mol. Hum. Reprod. (1999) [Pubmed]
  25. Tumor necrosis factor-alpha upregulates angiopoietin-2 in human umbilical vein endothelial cells. Kim, I., Kim, J.H., Ryu, Y.S., Liu, M., Koh, G.Y. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  26. Relationship between vascular endothelial growth factor and angiopoietin-2 in asthmatics before and after inhaled beclomethasone therapy. Nomura, S., Kanazawa, H., Hirata, K., Iwao, H., Yoshikawa, J. The Journal of asthma : official journal of the Association for the Care of Asthma. (2005) [Pubmed]
  27. Cyclical mechanical stretch enhances angiopoietin-2 and Tie2 receptor expression in cultured human umbilical vein endothelial cells. Chang, H., Wang, B.W., Kuan, P., Shyu, K.G. Clin. Sci. (2003) [Pubmed]
  28. Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition. Barton, W.A., Tzvetkova, D., Nikolov, D.B. Structure (Camb.) (2005) [Pubmed]
  29. Altered expression of angiopoietins and Tie2 endothelium receptor in psoriasis. Kuroda, K., Sapadin, A., Shoji, T., Fleischmajer, R., Lebwohl, M. J. Invest. Dermatol. (2001) [Pubmed]
  30. Differential regulation of ANG2 and VEGF-A in human granulosa lutein cells by choriogonadotropin. Pietrowski, D., Keck, C. Exp. Clin. Endocrinol. Diabetes (2004) [Pubmed]
  31. Angiopoietin 2 induces cell cycle arrest in endothelial cells: a possible mechanism involved in advanced plaque neovascularization. Calvi, C., Dentelli, P., Pagano, M., Rosso, A., Pegoraro, M., Giunti, S., Garbarino, G., Camussi, G., Pegoraro, L., Brizzi, M.F. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  32. Angiopoietin switching regulates angiogenesis and progression of human hepatocellular carcinoma. Sugimachi, K., Tanaka, S., Taguchi, K., Aishima, S., Shimada, M., Tsuneyoshi, M. J. Clin. Pathol. (2003) [Pubmed]
  33. Parathyroid-produced angiopoietin-2 modulates angiogenic response. Carter, W.B., Ward, M.D. Surgery (2001) [Pubmed]
  34. Plasma vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in diabetes: implications for cardiovascular risk and effects of multifactorial intervention. Lim, H.S., Blann, A.D., Chong, A.Y., Freestone, B., Lip, G.Y. Diabetes Care (2004) [Pubmed]
  35. Angiopoietin-1, unlike angiopoietin-2, is incorporated into the extracellular matrix via its linker peptide region. Xu, Y., Yu, Q. J. Biol. Chem. (2001) [Pubmed]
  36. Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure. Chong, A.Y., Caine, G.J., Freestone, B., Blann, A.D., Lip, G.Y. J. Am. Coll. Cardiol. (2004) [Pubmed]
  37. Clinical significance of angiopoietin-2 expression at the deepest invasive tumor site of advanced colorectal carcinoma. Ochiumi, T., Tanaka, S., Oka, S., Hiyama, T., Ito, M., Kitadai, Y., Haruma, K., Chayama, K. Int. J. Oncol. (2004) [Pubmed]
  38. Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma. Torimura, T., Ueno, T., Kin, M., Harada, R., Taniguchi, E., Nakamura, T., Sakata, R., Hashimoto, O., Sakamoto, M., Kumashiro, R., Sata, M., Nakashima, O., Yano, H., Kojiro, M. J. Hepatol. (2004) [Pubmed]
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