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Gene Review

ANGPTL1  -  angiopoietin-like 1

Homo sapiens

Synonyms: ANG-3, ANG3, ANGPT3, ARP1, AngY, ...
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Disease relevance of ANGPTL1


High impact information on ANGPTL1


Chemical compound and disease context of ANGPTL1


Biological context of ANGPTL1


Anatomical context of ANGPTL1


Associations of ANGPTL1 with chemical compounds


Other interactions of ANGPTL1


Analytical, diagnostic and therapeutic context of ANGPTL1


  1. Biological characterization of angiopoietin-3 and angiopoietin-4. Lee, H.J., Cho, C.H., Hwang, S.J., Choi, H.H., Kim, K.T., Ahn, S.Y., Kim, J.H., Oh, J.L., Lee, G.M., Koh, G.Y. FASEB J. (2004) [Pubmed]
  2. Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. Galaup, A., Cazes, A., Le Jan, S., Philippe, J., Connault, E., Le Coz, E., Mekid, H., Mir, L.M., Opolon, P., Corvol, P., Monnot, C., Germain, S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Angiopoietin-3 inhibits pulmonary metastasis by inhibiting tumor angiogenesis. Xu, Y., Liu, Y.J., Yu, Q. Cancer Res. (2004) [Pubmed]
  4. Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor. Inaba, T., Matsuda, M., Shimamura, M., Takei, N., Terasaka, N., Ando, Y., Yasumo, H., Koishi, R., Makishima, M., Shimomura, I. J. Biol. Chem. (2003) [Pubmed]
  5. Transcriptional activation by the orphan nuclear receptor ARP-1. Malik, S., Karathanasis, S. Nucleic Acids Res. (1995) [Pubmed]
  6. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Zhang, C.C., Kaba, M., Ge, G., Xie, K., Tong, W., Hug, C., Lodish, H.F. Nat. Med. (2006) [Pubmed]
  7. Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Sukonina, V., Lookene, A., Olivecrona, T., Olivecrona, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Xu, A., Lam, M.C., Chan, K.W., Wang, Y., Zhang, J., Hoo, R.L., Xu, J.Y., Chen, B., Chow, W.S., Tso, A.W., Lam, K.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Genetics and regulation of angiopoietin-like proteins 3 and 4. Li, C. Curr. Opin. Lipidol. (2006) [Pubmed]
  10. PC cell-derived growth factor confers resistance to dexamethasone and promotes tumorigenesis in human multiple myeloma. Wang, W., Hayashi, J., Serrero, G. Clin. Cancer Res. (2006) [Pubmed]
  11. Angiopoietin-3, a novel member of the angiopoietin family. Nishimura, M., Miki, T., Yashima, R., Yokoi, N., Yano, H., Sato, Y., Seino, S. FEBS Lett. (1999) [Pubmed]
  12. Angiogenesis gene expression profiling in xenograft models to study cellular interactions. Thijssen, V.L., Brandwijk, R.J., Dings, R.P., Griffioen, A.W. Exp. Cell Res. (2004) [Pubmed]
  13. Regulation of the angiopoietin-like protein 3 gene by LXR. Kaplan, R., Zhang, T., Hernandez, M., Gan, F.X., Wright, S.D., Waters, M.G., Cai, T.Q. J. Lipid Res. (2003) [Pubmed]
  14. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3. Kim, I., Kwak, H.J., Ahn, J.E., So, J.N., Liu, M., Koh, K.N., Koh, G.Y. FEBS Lett. (1999) [Pubmed]
  15. Comparison of the patterns of expression of rat intestinal fatty acid binding protein/human growth hormone fusion genes in cultured intestinal epithelial cell lines and in the gut epithelium of transgenic mice. Rottman, J.N., Gordon, J.I. J. Biol. Chem. (1993) [Pubmed]
  16. Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Köster, A., Chao, Y.B., Mosior, M., Ford, A., Gonzalez-DeWhitt, P.A., Hale, J.E., Li, D., Qiu, Y., Fraser, C.C., Yang, D.D., Heuer, J.G., Jaskunas, S.R., Eacho, P. Endocrinology (2005) [Pubmed]
  17. Peroxisome proliferator-activated receptor-gamma agonist is protective in podocyte injury-associated sclerosis. Yang, H.C., Ma, L.J., Ma, J., Fogo, A.B. Kidney Int. (2006) [Pubmed]
  18. Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Shimamura, M., Matsuda, M., Yasumo, H., Okazaki, M., Fujimoto, K., Kono, K., Shimizugawa, T., Ando, Y., Koishi, R., Kohama, T., Sakai, N., Kotani, K., Komuro, R., Ishida, T., Hirata, K., Yamashita, S., Furukawa, H., Shimomura, I. Arterioscler. Thromb. Vasc. Biol. (2007) [Pubmed]
  19. Identification of a novel human angiopoietin-like gene expressed mainly in heart. Zeng, L., Dai, J., Ying, K., Zhao, E., Jin, W., Ye, Y., Dai, J., Xu, J., Xie, Y., Mao, Y. J. Hum. Genet. (2003) [Pubmed]
  20. ANGPTL3 is increased in both insulin-deficient and -resistant diabetic states. Inukai, K., Nakashima, Y., Watanabe, M., Kurihara, S., Awata, T., Katagiri, H., Oka, Y., Katayama, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  21. Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1. Jordan, E.M., Worley, T., Breen, G.A. Biochemistry (2003) [Pubmed]
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