Disease relevance of ANGPTL1

• Ang3 and Ang4 both produced potent corneal angiogenesis extending from the limbus across the mouse cornea in vivo [1].
• Angiopoietin-like 4 (ANGPTL4), a secreted protein of the angiopoietin-like family, is induced by hypoxia in both tumor and endothelial cells as well as in hypoxic perinecrotic areas of numerous cancers [2].
• Angiopoietin-3 inhibits pulmonary metastasis by inhibiting tumor angiogenesis [3].
• Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor [4].
• ARP-1 is a ubiquitous orphan nuclear receptor that binds to a site (site A) in the apolipoprotein AI (apoAI) liver-specific enhancer and represses its transcriptional activity in hepatoblastoma HepG2 cells [5].

High impact information on ANGPTL1

• Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells [6].
• Recent data indicate that angiopoietin-like protein (Angptl)-4 inhibits LPL and retards lipoprotein catabolism [7].
• Angiopoietin-like protein 4 (ANGPTL4) is a circulating protein predominantly expressed in adipose tissue and liver [8].
• Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice [8].
• Genetics and regulation of angiopoietin-like proteins 3 and 4 [9].

Chemical compound and disease context of ANGPTL1

• EXPERIMENTAL DESIGN: PCDGF functions and signaling pathways in dexamethasone-induced apoptosis were studied using a representative dexamethasone-sensitive multiple myeloma cell line ARP-1 [10].

Biological context of ANGPTL1

• Ang3 cDNA was cloned from a human aorta cDNA library [11].
• We conclude that ARP-1 possesses intrinsic transcription activation potential which is modulated, at least in part, by the intracellular balance of other nuclear receptors that also bind to its cognate DNA binding site [5].
• Transcriptional activation by the orphan nuclear receptor ARP-1 [5].
• This was accompanied by downregulation of VEGF-B and -D, and upregulation of angiopoietin-3 as well as angiopoetin receptors in nontumor cells [12].
• One family member, angiopoietin-like protein 3 (Angptl3), was recently shown to be predominantly expressed in the liver and to play an important role in regulating lipid metabolism [13].

Anatomical context of ANGPTL1

• Additionally, Ang3 is a secretory protein, but is not a mitogen in endothelial cells [14].
• Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs) [11].
• Ang3 mRNA is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine in human adult tissues [14].
• This element binds to two members of the steroid hormone receptor superfamily of transcription factors produced in enterocytes and Caco-2 cells: hepatic nuclear factor-4 (HNF-4) and apolipoprotein regulatory protein-1 (ARP-1) [15].
• In in vitro transcription assays, Hela cell nuclear extracts which contain ARP-1 had no effect on transcription from a basal promoter linked to multiple copies of site A [5].

Associations of ANGPTL1 with chemical compounds

• Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism [16].
• Pio also decreased renal cortical angiopoietin-like protein 4 expression to almost 20% of CONT group, associated with increased vascular endothelial-derived growth factor expression in glomeruli [17].
• Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase [18].

Other interactions of ANGPTL1

• Biological characterization of angiopoietin-3 and angiopoietin-4 [1].
• Angiopoietin-3, a novel member of the angiopoietin family [11].
• During large-scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel human angiopoietin-like cDNA and termed it human angiopoietin-like 5 ( ANGPTL5) [19].
• Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue [7].
• Angiopoietin-like protein 3 (ANGPTL3) is secreted by the liver and was recently postulated to be an important hormone regulating serum triglyceride levels [20].

Analytical, diagnostic and therapeutic context of ANGPTL1

• Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3 [14].
• Mobility shift assays revealed that COUP-TFII/ARP-1 and USF2 compete for binding to the ATPA regulatory element 1 [21].
• Co-immunoprecipitation assays using ARP-1-selective antibodies revealed specific physical interactions between ARP-1 and the basal transcription factor TFIIB [5].

References