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Gene Review

VASP  -  vasodilator-stimulated phosphoprotein

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High impact information on MGC127789

  • We present a study on the binding properties of the bovine profilin isoforms to both phosphatidylinositol 4,5-bisphosphate (PIP2) and proline-rich peptides derived from vasodilator-stimulated phosphoprotein (VASP) and cyclase-associated protein (CAP) [1].
  • Both compounds increased cGMP levels in cultured rat aortic smooth muscle cells; induced vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum (EC50 1 to 10 microM); and elicited phosphorylation of the cGMP kinase substrate vasodilator-stimulated phosphoprotein at Ser239 [2].
  • GTN, ISMN, and PETN acted synergistically with sildenafil (1 microM) on inhibition of PDGF-induced DNA synthesis, increase of intracellular cyclic nucleotides, and vasodilator-stimulated phosphoprotein phosphorylation [3].
  • Thrombin-induced platelet aggregation was inhibited by GEA 3175 in a cyclic GMP- and vasodilator-stimulated phosphoprotein (VASP)-phosphorylation-dependent manner [4].
  • Vasodilator-stimulated phosphoprotein (VASP) is highly expressed in vascular endothelial cells, where it has been implicated in cellular reorganization during angiogenesis, as well as in endothelial retraction and changes in vessel permeability [5].

Biological context of MGC127789


Anatomical context of MGC127789


Associations of MGC127789 with chemical compounds

  • Quantitatively, 8-pCPT-cGMP was more effective than 8-Br-cGMP in inducing phosphorylation of the 46/50 kDa vasodilator-stimulated phosphoprotein, a major substrate of cGMP-PK in intact platelets [7].


  1. The mammalian profilin isoforms display complementary affinities for PIP2 and proline-rich sequences. Lambrechts, A., Verschelde, J.L., Jonckheere, V., Goethals, M., Vandekerckhove, J., Ampe, C. EMBO J. (1997) [Pubmed]
  2. Biochemistry and pharmacology of novel anthranilic acid derivatives activating heme-oxidized soluble guanylyl cyclase. Schindler, U., Strobel, H., Schönafinger, K., Linz, W., Löhn, M., Martorana, P.A., Rütten, H., Schindler, P.W., Busch, A.E., Sohn, M., Töpfer, A., Pistorius, A., Jannek, C., Mülsch, A. Mol. Pharmacol. (2006) [Pubmed]
  3. Antimitogenic actions of organic nitrates are potentiated by sildenafil and mediated via activation of protein kinase A. Osinski, M.T., Rauch, B.H., Schrör, K. Mol. Pharmacol. (2001) [Pubmed]
  4. Potential Protective Properties of a Stable, Slow-releasing Nitric Oxide Donor, GEA 3175, in the Lung. Laursen, B.E., Stankevicius, E., Pilegaard, H., Mulvany, M., Simonsen, U. Cardiovascular drug reviews (2006) [Pubmed]
  5. Vasodilator-stimulated phosphoprotein is involved in stress-fiber and membrane ruffle formation in endothelial cells. Price, C.J., Brindle, N.P. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  6. Antimitogenic effects of trapidil in coronary artery smooth muscle cells by direct activation of protein kinase A. Bönisch, D., Weber, A.A., Wittpoth, M., Osinski, M., Schrör, K. Mol. Pharmacol. (1998) [Pubmed]
  7. Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP. Butt, E., Nolte, C., Schulz, S., Beltman, J., Beavo, J.A., Jastorff, B., Walter, U. Biochem. Pharmacol. (1992) [Pubmed]
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