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Chemical Compound Review

Br Cgmp     2-amino-8-bromo-9- [(1S,6R,8R,9R)-3,9...

Synonyms: AG-F-04391, SureCN3991263, CHEBI:64108, AC1L2XGK, AR-1D8685, ...
 
 
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Disease relevance of Br Cgmp

 

Psychiatry related information on Br Cgmp

 

High impact information on Br Cgmp

  • Moreover, sodium nitroprusside and 8-bromo cyclic GMP induce similar patterns of protein phosphorylation in intact rat thoracic aorta [9].
  • Likewise, ANP and 8-bromo-cGMP attenuated the alpha1-adrenergic receptor- stimulated increase in prepro-ANP mRNA and the alpha1-adrenergic receptor-stimulated decrease in sarcoplasmic reticulum calcium ATPase mRNA [10].
  • Furthermore, in myocytes, 8-bromo-cGMP attenuated the alpha1-adrenergic receptor-stimulated increases in c-fos [10].
  • Activation of cGKs by 8-bromo-cGMP decreased renin secretion from the isolated perfused rat kidney, independent of prestimulation by beta-adrenoreceptor activation, macula densa inhibition, reduced perfusion pressure, or by a nominally calcium-free perfusate [11].
  • Short circuit current (ISC), a measure of Cl- secretion, was increased to a similar extent by STa and by 8-Br-cGMP, a selective activator of cGK, except in distal colon and in monolayers of T84 human colon carcinoma cells in which cGK II was not detected [12].
 

Chemical compound and disease context of Br Cgmp

 

Biological context of Br Cgmp

 

Anatomical context of Br Cgmp

 

Associations of Br Cgmp with other chemical compounds

  • The effect of chlorpromazine on intestinal secretion was quantitatively similar regardless of whether heat-stable enterotoxin or the cyclic GMP analogue, 8-Br-cyclic GMP, was the secretagogue [1].
  • HCS and carboxylase mRNA levels in normal and MCD fibroblasts and HepG2 cells can be restored by the addition of the cGMP analogue, 8-Br-cGMP, and can be abolished by the addition of inhibitors of the soluble form of guanylate cyclase [26].
  • The effect of SNP on DARPP-32 phosphorylation was mimicked by low concentrations of 8-bromo-cGMP and 8-(4-chlorophenylthio)-guanosine 3',5'-cyclic monophosphate, activators of cGMP-dependent protein kinase, but not by low concentrations of 8-bromo-cAMP, an activator of cAMP-dependent protein kinase [27].
  • The cytostatic effects of GC-C agonists were associated with accumulation of intracellular cGMP, mimicked by the cell-permeant analog 8-Br-cGMP, and reproduced and potentiated by the cGMP-specific phosphodiesterase inhibitor zaprinast but not the inactive ST analog TJU 1-103 [28].
  • The mitochondrial uncoupler dinitrophenol blocked the effects of 8-bromo-cGMP but only slightly altered those of SNAP, indicating that the major site of action of NO is the mitochondria [19].
 

Gene context of Br Cgmp

 

Analytical, diagnostic and therapeutic context of Br Cgmp

References

  1. Effect of chlorpromazine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin and 8-Br-cyclic GMP in infant mice. Robins-Browne, R.M., Levine, M.M. Gastroenterology (1981) [Pubmed]
  2. Escherichia coli heat-stable enterotoxin-mediated colonic Cl- secretion is absent in cystic fibrosis. Goldstein, J.L., Sahi, J., Bhuva, M., Layden, T.J., Rao, M.C. Gastroenterology (1994) [Pubmed]
  3. Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo. Lei, B., Matsuo, K., Labinskyy, V., Sharma, N., Chandler, M.P., Ahn, A., Hintze, T.H., Stanley, W.C., Recchia, F.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Reduced production of cGMP underlies the loss of endothelium-dependent relaxations in the canine basilar artery after subarachnoid hemorrhage. Kim, P., Schini, V.B., Sundt, T.M., Vanhoutte, P.M. Circ. Res. (1992) [Pubmed]
  5. Second messenger modulation of the asialoglycoprotein receptor. Stockert, R.J., Morell, A.G. J. Biol. Chem. (1990) [Pubmed]
  6. Effects of excitatory amino acids and nitric oxide on flight behavior elicited from the dorsolateral periaqueductal gray. De Oliveira, R.M., Del Bel, E.A., Guimarães, F.S. Neuroscience and biobehavioral reviews. (2001) [Pubmed]
  7. The nitric oxide-guanosine 3',5'-cyclic monophosphate pathway regulates dopamine efflux in the medial preoptic area and copulation in male rats. Sato, S.M., Hull, E.M. Neuroscience (2006) [Pubmed]
  8. The effects of intracerebroventricular application of 8-Br-cGMP and LY-83,583, a guanylyl cyclase inhibitor, on sleep-wake activity in rats. Ribeiro, A.C., Kapás, L. Brain Res. (2005) [Pubmed]
  9. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Rapoport, R.M., Draznin, M.B., Murad, F. Nature (1983) [Pubmed]
  10. Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts. Calderone, A., Thaik, C.M., Takahashi, N., Chang, D.L., Colucci, W.S. J. Clin. Invest. (1998) [Pubmed]
  11. Role of cGMP-kinase II in the control of renin secretion and renin expression. Wagner, C., Pfeifer, A., Ruth, P., Hofmann, F., Kurtz, A. J. Clin. Invest. (1998) [Pubmed]
  12. Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator. Markert, T., Vaandrager, A.B., Gambaryan, S., Pöhler, D., Häusler, C., Walter, U., De Jonge, H.R., Jarchau, T., Lohmann, S.M. J. Clin. Invest. (1995) [Pubmed]
  13. Adenovirus-mediated gene transfer of cGMP-dependent protein kinase increases the sensitivity of cultured vascular smooth muscle cells to the antiproliferative and pro-apoptotic effects of nitric oxide/cGMP. Chiche, J.D., Schlutsmeyer, S.M., Bloch, D.B., de la Monte, S.M., Roberts, J.D., Filippov, G., Janssens, S.P., Rosenzweig, A., Bloch, K.D. J. Biol. Chem. (1998) [Pubmed]
  14. Neurotoxicity of A beta amyloid protein in vitro is not altered by calcium channel blockade. Whitson, J.S., Appel, S.H. Neurobiol. Aging (1995) [Pubmed]
  15. Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies. Edmunds, N.J., Moncada, S., Marshall, J.M. J. Physiol. (Lond.) (2003) [Pubmed]
  16. Nitric oxide from perivascular nerves modulates cerebral arterial pH reactivity. Lindauer, U., Kunz, A., Schuh-Hofer, S., Vogt, J., Dreier, J.P., Dirnagl, U. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  17. Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. Suematsu, M., Goda, N., Sano, T., Kashiwagi, S., Egawa, T., Shinoda, Y., Ishimura, Y. J. Clin. Invest. (1995) [Pubmed]
  18. Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments. Zimmerman, A.L., Yamanaka, G., Eckstein, F., Baylor, D.A., Stryer, L. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  19. Nitric oxide. An important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption. Shen, W., Hintze, T.H., Wolin, M.S. Circulation (1995) [Pubmed]
  20. cGMP and atrial natriuretic factor regulate cell volume of rabbit atrial myocytes. Clemo, H.F., Baumgarten, C.M. Circ. Res. (1995) [Pubmed]
  21. Role of endothelium-derived nitric oxide in the modulation of canine myocardial mitochondrial respiration in vitro. Implications for the development of heart failure. Xie, Y.W., Shen, W., Zhao, G., Xu, X., Wolin, M.S., Hintze, T.H. Circ. Res. (1996) [Pubmed]
  22. Inhibition of Na/H exchange in avian intestine by atrial natriuretic factor. Semrad, C.E., Cragoe, E.J., Chang, E.B. J. Clin. Invest. (1990) [Pubmed]
  23. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Rashatwar, S.S., Cornwell, T.L., Lincoln, T.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  24. cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions. Griffith, T.M., Chaytor, A.T., Taylor, H.J., Giddings, B.D., Edwards, D.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  25. Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation. Khromov, A.S., Wang, H., Choudhury, N., McDuffie, M., Herring, B.P., Nakamoto, R., Owens, G.K., Somlyo, A.P., Somlyo, A.V. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  26. Holocarboxylase synthetase is an obligate participant in biotin-mediated regulation of its own expression and of biotin-dependent carboxylases mRNA levels in human cells. Solórzano-Vargas, R.S., Pacheco-Alvarez, D., León-Del-Río, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. Nitric oxide/cGMP pathway stimulates phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, in the substantia nigra. Tsou, K., Snyder, G.L., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  28. Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells. Pitari, G.M., Di Guglielmo, M.D., Park, J., Schulz, S., Waldman, S.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  29. Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Prasad, H.C., Zhu, C.B., McCauley, J.L., Samuvel, D.J., Ramamoorthy, S., Shelton, R.C., Hewlett, W.A., Sutcliffe, J.S., Blakely, R.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  30. Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines. Koide, M., Kawahara, Y., Nakayama, I., Tsuda, T., Yokoyama, M. J. Biol. Chem. (1993) [Pubmed]
  31. Natriuretic peptide regulation of endochondral ossification. Evidence for possible roles of the C-type natriuretic peptide/guanylyl cyclase-B pathway. Yasoda, A., Ogawa, Y., Suda, M., Tamura, N., Mori, K., Sakuma, Y., Chusho, H., Shiota, K., Tanaka, K., Nakao, K. J. Biol. Chem. (1998) [Pubmed]
  32. NO suppresses while peroxynitrite sustains NF-kappaB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO. Hattori, Y., Kasai, K., Gross, S.S. Cardiovasc. Res. (2004) [Pubmed]
  33. Differential effects of melatonin and its downstream effector PKCalpha on subcellular localization of RGS proteins. Rimler, A., Jockers, R., Lupowitz, Z., Sampson, S.R., Zisapel, N. J. Pineal Res. (2006) [Pubmed]
  34. Emergence of insulin receptors upon alloimmune T cells in the rat. Helderman, J.H., Strom, T.B. J. Clin. Invest. (1977) [Pubmed]
  35. The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation. Pinsky, D.J., Naka, Y., Chowdhury, N.C., Liao, H., Oz, M.C., Michler, R.E., Kubaszewski, E., Malinski, T., Stern, D.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  36. Involvement of cGMP in nociceptive processing by and sensitization of spinothalamic neurons in primates. Lin, Q., Peng, Y.B., Wu, J., Willis, W.D. J. Neurosci. (1997) [Pubmed]
  37. Atrial natriuretic peptide stimulates the expression of transforming growth factor-beta in cultured murine mesangial cells: relationship to suppression of proliferation. Wolf, G., Ziyadeh, F.N., Stahl, R.A. J. Am. Soc. Nephrol. (1995) [Pubmed]
 
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