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Gene Review

SIRT7  -  sirtuin 7

Homo sapiens

Synonyms: NAD-dependent protein deacetylase sirtuin-7, Regulatory protein SIR2 homolog 7, SIR2-like protein 7, SIR2L7
 
 
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Disease relevance of SIRT7

 

High impact information on SIRT7

 

Biological context of SIRT7

  • We show that SIRT7 is a widely expressed nucleolar protein that is associated with active rRNA genes (rDNA), where it interacts with RNA polymerase I (Pol I) as well as with histones [3].
  • Determination of the exon/intron splice junctions found the full-length SIRT7 protein to consist of 10 exons ranging in size from 71 bp (exon 4) to 237 bp (exon 7) [2].
  • Characterization of the 5' flanking genomic region, which precedes the Sirt7 open reading frame, revealed a TATA- and CCAAT-box less promoter that lacks CpG islands [2].
 

Anatomical context of SIRT7

  • Human SIRT7 appears to be most predominantly expressed in the blood and in CD33+ myeloid bone marrow precursor cells, while the lowest levels are found in the ovaries and skeletal muscle [2].
 

Other interactions of SIRT7

  • Here, two new human sirtuins (SIRT6 and SIRT7) are found to be similar to a particular subset of insect, nematode, plant, and protozoan sirtuins [5].

References

  1. Altered sirtuin expression is associated with node-positive breast cancer. Ashraf, N., Zino, S., Macintyre, A., Kingsmore, D., Payne, A.P., George, W.D., Shiels, P.G. Br. J. Cancer (2006) [Pubmed]
  2. Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene. Voelter-Mahlknecht, S., Letzel, S., Mahlknecht, U. Int. J. Oncol. (2006) [Pubmed]
  3. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Ford, E., Voit, R., Liszt, G., Magin, C., Grummt, I., Guarente, L. Genes Dev. (2006) [Pubmed]
  4. "SIRT8" expressed in thyroid cancer is actually SIRT7. Frye, R. Br. J. Cancer (2002) [Pubmed]
  5. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Frye, R.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
 
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