The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SIRT7  -  sirtuin 7

Homo sapiens

Synonyms: NAD-dependent protein deacetylase sirtuin-7, Regulatory protein SIR2 homolog 7, SIR2-like protein 7, SIR2L7
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SIRT7


High impact information on SIRT7


Biological context of SIRT7

  • We show that SIRT7 is a widely expressed nucleolar protein that is associated with active rRNA genes (rDNA), where it interacts with RNA polymerase I (Pol I) as well as with histones [3].
  • Determination of the exon/intron splice junctions found the full-length SIRT7 protein to consist of 10 exons ranging in size from 71 bp (exon 4) to 237 bp (exon 7) [2].
  • Characterization of the 5' flanking genomic region, which precedes the Sirt7 open reading frame, revealed a TATA- and CCAAT-box less promoter that lacks CpG islands [2].

Anatomical context of SIRT7

  • Human SIRT7 appears to be most predominantly expressed in the blood and in CD33+ myeloid bone marrow precursor cells, while the lowest levels are found in the ovaries and skeletal muscle [2].

Other interactions of SIRT7

  • Here, two new human sirtuins (SIRT6 and SIRT7) are found to be similar to a particular subset of insect, nematode, plant, and protozoan sirtuins [5].


  1. Altered sirtuin expression is associated with node-positive breast cancer. Ashraf, N., Zino, S., Macintyre, A., Kingsmore, D., Payne, A.P., George, W.D., Shiels, P.G. Br. J. Cancer (2006) [Pubmed]
  2. Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene. Voelter-Mahlknecht, S., Letzel, S., Mahlknecht, U. Int. J. Oncol. (2006) [Pubmed]
  3. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Ford, E., Voit, R., Liszt, G., Magin, C., Grummt, I., Guarente, L. Genes Dev. (2006) [Pubmed]
  4. "SIRT8" expressed in thyroid cancer is actually SIRT7. Frye, R. Br. J. Cancer (2002) [Pubmed]
  5. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Frye, R.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
WikiGenes - Universities