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Gene Review

NOP58  -  NOP58 ribonucleoprotein

Homo sapiens

Synonyms: HSPC120, NOL5, NOP5, NOP5/NOP58, Nucleolar protein 5, ...
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High impact information on NOP5/NOP58

  • In contrast, as shown previously, stem II of the kink-turn motif in box C/D snoRNAs is comprised of three base pairs, and NOP56 and NOP58 require a G-C pair at the central position [1].
  • Structural and thermodynamic evidence for a stabilizing role of Nop5p in S-adenosyl-L-methionine binding to fibrillarin [2].
  • This structure exhibited a pre-formed backbone geometry at the cofactor binding site similar to that when the cofactor is bound, suggesting that binding of Nop5p alone to fibrillarin is sufficient to stabilize the AdoMet-binding pocket [2].
  • Our results suggest that L7Ae facilitates the folding of the K-turn motifs (chaperone function) and, in addition, is required for methylation activity in the presence of Nop5 and Fib [3].
  • Human NOP5 cDNA was isolated from an M426 fibroblast cDNA library [4].

Biological context of NOP5/NOP58

  • In Archaea, fibrillarin and Nop5p form the core complex of box C/D small ribonucleoprotein particles, which are responsible for site-specific 2'-hydroxyl methylation of ribosomal and transfer RNAs [2].

Associations of NOP5/NOP58 with chemical compounds

  • Pretreatment with cycloheximide enhanced, while actinomycin blocked induction of the NOP5 transcript [4].

Other interactions of NOP5/NOP58

  • To identify the structural elements responsible for these large conformational differences, we refined a crystal structure of Archaeoglobus fulgidus fibrillarin-Nop5p binary complex at 3.5 A [2].

Analytical, diagnostic and therapeutic context of NOP5/NOP58

  • Ubiquitous, but differential NOP5 mRNA expression was revealed after Northern blot analysis of total RNA from several human tissues [4].
  • Using a differential display RT-PCR strategy to identify novel growth-factor-induced transcripts, we cloned and characterized the human homolog of yeast NOP5/NOP58, whose gene product has been implicated in the execution of early pre-rRNA processing steps [4].


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