Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ZNF44 - zinc finger protein 44

Homo sapiens

Synonyms: GIOT-2, GIOT2, Gonadotropin-inducible ovary transcription repressor 2, KOX7, ZNF, ...

Mizutani, T. et al., Eichler, E.E. et al., Vogel, M.J. et al., Huebner, K. et al.

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High impact information on ZNF44

High-resolution mapping on human chromosome 19 revealed that CBX1 coats large domains 0.1-4 Mb in size, which coincide with the position of KRAB-ZNF gene clusters [1].
Interestingly, the gene expression of GIOT1 is restricted to the pituitary, adrenal, testis, and ovary, while GIOT2 gene is expressed ubiquitously [2].
Two isoforms of GIOT2 (GIOT2 alpha and 2 beta), which are probably produced by alternative splicing, also exist [2].
Nucleotide sequence analysis revealed that GIOT1, but not GIOT2, contains the krüppel-associated box-A domain at the NH(2) terminus [2].
cDNA clones encoding zinc finger motifs were isolated by screening human placenta and T-cell (Peer) cDNA libraries with zinc finger (ZNF) consensus sequences [3].

Biological context of ZNF44

Hybridization analysis using the beta-satellite repeat as a probe indicates that beta-satellite interspersion between ZNF gene cassettes is a general property for 1.5 Mb of the ZNF gene cluster in 19p12 [4].

References

Human heterochromatin proteins form large domains containing KRAB-ZNF genes. Vogel, M.J., Guelen, L., de Wit, E., Hupkes, D.P., Lod??n, M., Talhout, W., Feenstra, M., Abbas, B., Classen, A.K., van Steensel, B. Genome Res. (2006) [Pubmed]
Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Mizutani, T., Yamada, K., Yazawa, T., Okada, T., Minegishi, T., Miyamoto, K. Mol. Endocrinol. (2001) [Pubmed]
Chromosomal localization of four human zinc finger cDNAs. Huebner, K., Druck, T., LaForgia, S., Lasota, J., Croce, C.M., Lanfrancone, L., Donti, E., Pengue, G., La Mantia, G., Pelicci, P.G. Hum. Genet. (1993) [Pubmed]
Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12. Eichler, E.E., Hoffman, S.M., Adamson, A.A., Gordon, L.A., McCready, P., Lamerdin, J.E., Mohrenweiser, H.W. Genome Res. (1998) [Pubmed]

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