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Gene Review

ZNF461  -  zinc finger protein 461

Homo sapiens

Synonyms: GIOT-1, GIOT1, Gonadotropin-inducible ovary transcription repressor 1, MGC33911, Zinc finger protein 461
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High impact information on ZNF461


Biological context of ZNF461


Anatomical context of ZNF461


Other interactions of ZNF461

  • The ZNF460 cDNA is 3,135 bp in length encoding a 562-amino-acid polypeptide and the ZNF461 cDNA is 2,548 bp encoding a 563-amino-acid protein [2].

Analytical, diagnostic and therapeutic context of ZNF461

  • Our fly Protein Interaction Map (PIM) is surprisingly different from the one recently proposed by Giot et al. with little overlap between the two data sets [4].


  1. Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2. Song, K.H., Park, Y.Y., Kee, H.J., Hong, C.Y., Lee, Y.S., Ahn, S.W., Kim, H.J., Lee, K., Kook, H., Lee, I.K., Choi, H.S. J. Biol. Chem. (2006) [Pubmed]
  2. Characterization of two novel KRAB-domain-containing zinc finger genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4. Dai, J., Li, Y., Ji, C., Jin, F., Zheng, Z., Wang, X., Sun, X., Xu, X., Gu, S., Xie, Y., Mao, Y. Cytogenet. Genome Res. (2003) [Pubmed]
  3. Cloning and characterization of gonadotropin-inducible ovarian transcription factors (GIOT1 and -2) that are novel members of the (Cys)(2)-(His)(2)-type zinc finger protein family. Mizutani, T., Yamada, K., Yazawa, T., Okada, T., Minegishi, T., Miyamoto, K. Mol. Endocrinol. (2001) [Pubmed]
  4. Protein interaction mapping: a Drosophila case study. Formstecher, E., Aresta, S., Collura, V., Hamburger, A., Meil, A., Trehin, A., Reverdy, C., Betin, V., Maire, S., Brun, C., Jacq, B., Arpin, M., Bellaiche, Y., Bellusci, S., Benaroch, P., Bornens, M., Chanet, R., Chavrier, P., Delattre, O., Doye, V., Fehon, R., Faye, G., Galli, T., Girault, J.A., Goud, B., de Gunzburg, J., Johannes, L., Junier, M.P., Mirouse, V., Mukherjee, A., Papadopoulo, D., Perez, F., Plessis, A., Rossé, C., Saule, S., Stoppa-Lyonnet, D., Vincent, A., White, M., Legrain, P., Wojcik, J., Camonis, J., Daviet, L. Genome Res. (2005) [Pubmed]
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