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Gene Review

PFAS  -  phosphoribosylformylglycinamidine synthase

Homo sapiens

Synonyms: FGAM synthase, FGAMS, FGAR amidotransferase, FGAR-AT, FGARAT, ...
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Disease relevance of PFAS


High impact information on PFAS

  • The expression of both the GARS and GARS-AIRS-GART proteins are regulated during development of the human cerebellum, while the expression of FGARAT appears to be constitutive [4].
  • The enzyme catalyzing the intervening fourth step of de novo purine biosynthesis, phosphoribosylformylglycineamide amidotransferase (FGARAT), is encoded by a separate gene on chromosome 17 [4].
  • A comparison of the DNA sequence of the human FGARAT and FGARAT DNA sequence from 17 other organisms is reported [3].
  • CONCLUSIONS: Our study suggests that a higher PFAS, accompanied by a single-sector infarction, is a predictor of improved clinical outcome in patients with vertebrobasilar ischemic stroke in which the basilar artery was absent on MRA [2].
  • This suggests that PFAS stain can be considered not only a technique for the demonstration of unsaturated lipids, but also a useful histochemical method in the study of lipid peroxidation [5].

Biological context of PFAS

  • Human phosphoribosylformylglycineamide amidotransferase (FGARAT): regional mapping, complete coding sequence, isolation of a functional genomic clone, and DNA sequence analysis [3].


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