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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PARN  -  poly(A)-specific ribonuclease

Bos taurus

 
 
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Disease relevance of LOC524155

 

High impact information on LOC524155

  • The differences of the DANS nucleotides versus the DAN and unsubstituted nucleotides as well as the nucleoside tri- versus diphosphate are rationalized in a specific H+ dependent regulatory mechanism at the binding site [2].
  • DAN nucleotides also fluoresce when adsorbed to Triton X-100 micelles that are used for solubilization of the carrier [3].
  • The binding to the ADP/ATP carrier in mitochondrial membranes of the 3'-O-(dimethylamino)naphthoyl (DAN) derivatives of AMP, ADP, and ATP was quantitatively analyzed [4].
  • Relative abundances of MSY2, PARN, and YY1 mRNA (P < 0.05) were significantly lower in oocytes from persistent than from growing follicles [5].

References

  1. Interaction of 4,5-dibromo-2,7-di-(acetatomercuri)-fluorescein with DNAs of different base composition. Dattagupta, N., Bünemann, H., Müller, W. Biochim. Biophys. Acta (1975) [Pubmed]
  2. Fluorescent nucleotide derivatives as specific probes for the uncoupling protein: thermodynamics and kinetics of binding and the control by pH. Huang, S.G., Klingenberg, M. Biochemistry (1995) [Pubmed]
  3. Interaction of fluorescent 3'-[1,5-(dimethylamino)naphthoyl]adenine nucleotides with the solubilized ADP/ATP carrier. Klingenberg, M., Mayer, I., Appel, M. Biochemistry (1985) [Pubmed]
  4. Interaction of fluorescent adenine nucleotide derivatives with the ADP/ATP carrier in mitochondria. 2. [5-(Dimethylamino)-1-naphthoyl]adenine nucleotides as probes for the transition between c and m states of the ADP/ATP carrier. Klingenberg, M., Mayer, I., Dahms, A.S. Biochemistry (1984) [Pubmed]
  5. Changes of maternal transcripts in oocytes from persistent follicles in cattle. Lingenfelter, B.M., Dailey, R.A., Inskeep, E.K., Vernon, M.W., Poole, D.H., Rhinehart, J.D., Yao, J. Mol. Reprod. Dev. (2007) [Pubmed]
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