Disease relevance of AHG2/ATPARN

• Consistent with the conservation of domains and residues important for catalytic activity, Arabidopsis PARN (AtPARN) expressed in Escherichia coli has poly(A) degradation activity in vitro [1].

High impact information on AHG2/ATPARN

• These results suggest that both upregulation and downregulation of gene expression by the mRNA-destabilizing activity of AtPARN are crucial for proper ABA, salicylic acid and stress responses [2].
• Map-based cloning of AHG2 revealed that this gene encodes a poly(A)-specific ribonuclease (AtPARN) that is presumed to function in mRNA degradation [2].
• Analysis of ABA hypersensitive germination2 revealed the pivotal functions of PARN in stress response in Arabidopsis [2].
• Importantly, only some, rather than all, embryo-specific transcripts were hyperadenylated in the mutant embryos, suggesting that preferential deadenylation of a specific select subset of mRNAs, rather than a general deadenylation of the whole mRNA population, by AtPARN is indispensable for embryogenesis in Arabidopsis [3].
• All three alleles cause lethality prior to seed germination, indicating that AtPARN is an essential gene first required during early development [1].

Associations of AHG2/ATPARN with chemical compounds

• Interestingly, expression of AtPARN was induced by treatment with ABA, high salinity and osmotic stress [2].

References