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Gene Review

Vhl  -  von Hippel-Lindau

Drosophila melanogaster

Synonyms: BcDNA:RH61560, CG13221, DVhl, Dmel\CG13221, Dvhl, ...
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Disease relevance of Vhl


High impact information on Vhl

  • Elongin B is found in cells as a subunit of the heterodimeric Elongin BC complex, which was originally identified as a positive regulator of RNA polymerase II elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau tumor suppressor and suppressor of cytokine signaling complexes [3].
  • Reduced d-VHL activity (using RNA interference methodology) caused breakage of the main vasculature accompanied by excessive looping of smaller branches, whereas over-expression caused a general lack of vasculature [1].
  • During embryogenesis, d-VHL is expressed in the developing tracheal regions where tube outgrowth no longer occurs [1].
  • The recombinant yeast Elongin C protein interacts with both mammalian Elongin A and VHL tumor suppressor protein [4].
  • The Elongin complex is a potential target for regulation by the von Hippel-Lindau (VHL) tumor suppressor protein, which is capable of binding stably to the Elongin BC complex and preventing it from activating Elongin A [4].

Associations of Vhl with chemical compounds

  • Firstly, HIFalpha undergoes trans -4-hydroxylation at two conserved proline residues that enable its recognition by the von Hippel-Lindau tumour-suppressor protein [5].


  1. Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila. Adryan, B., Decker, H.J., Papas, T.S., Hsu, T. Oncogene (2000) [Pubmed]
  2. Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. Aso, T., Yamazaki, K., Aigaki, T., Kitajima, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  3. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. Brower, C.S., Shilatifard, A., Mather, T., Kamura, T., Takagi, Y., Haque, D., Treharne, A., Foundling, S.I., Conaway, J.W., Conaway, R.C. J. Biol. Chem. (1999) [Pubmed]
  4. Molecular cloning of DNAs encoding the regulatory subunits of elongin from Saccharomyces cerevisiae and Drosophila melanogaster. Aso, T., Conrad, M.N. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  5. The role of iron and 2-oxoglutarate oxygenases in signalling. Hewitson, K.S., McNeill, L.A., Elkins, J.M., Schofield, C.J. Biochem. Soc. Trans. (2003) [Pubmed]
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