The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

cic  -  capicua

Drosophila melanogaster

Synonyms: CG43122, CG5060, CG5067, CIC, Cic, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on cic

  • We present evidence that Tor signaling regulates terminal patterning by inactivating Cic at the embryo poles. cic has been evolutionarily conserved, suggesting that Cic-like proteins may act as repressors regulated by RTK signaling in other organisms [1].
  • Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning [1].
  • We demonstrate that the terminal and posterior systems converge, and that exclusion of Capicua from the termini of posterior group mutants is ineffective, accounting for reduced terminal gap gene expression in these embryos [2].
  • Interestingly, ectopic expression of mirror in the absence of capicua is observed only in the anterior half of the epithelium [3].
  • EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins [4].
 

Biological context of cic

  • Although similar mutant phenotypes are observed with regulators of Egfr signaling, genetic analysis suggests that fet acts downstream of this event [5].
  • We provide evidence that EGFR signalling induces expression of vein-specific genes by inhibiting the Capicua (Cic) HMG-box repressor, a known regulator of embryonic body patterning [4].
  • The fet mutant phenotype is rescued by a transgene of capicua (cic), which encodes an HMG-box transcription factor [5].
  • Spatially distinct downregulation of Capicua repression and tailless activation by the Torso RTK pathway in the Drosophila embryo [6].
  • In addition, analysis of gene activation by the Torso pathway and downregulation of Capicua unveil differences between the terminal and the central embryonic regions that are independent of Torso signalling, hitherto thought to be the only system responsible for confering terminal specificities [6].
 

Anatomical context of cic

  • Our experiments reveal that cic controls dorsal-ventral patterning by regulating pipe expression in ovarian follicle cells, before its previously described role in interpreting the Dorsal gradient [5].
 

Other interactions of cic

  • Extending the current model, we show that activation of the Torso pathway can trigger tailless expression without eliminating Capicua [6].

References

  1. Relief of gene repression by torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Jiménez, G., Guichet, A., Ephrussi, A., Casanova, J. Genes Dev. (2000) [Pubmed]
  2. Capicua integrates input from two maternal systems in Drosophila terminal patterning. Cinnamon, E., Gur-Wahnon, D., Helman, A., St Johnston, D., Jiménez, G., Paroush, Z. EMBO J. (2004) [Pubmed]
  3. Capicua regulates follicle cell fate in the Drosophila ovary through repression of mirror. Atkey, M.R., Lachance, J.F., Walczak, M., Rebello, T., Nilson, L.A. Development (2006) [Pubmed]
  4. EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins. Roch, F., Jiménez, G., Casanova, J. Development (2002) [Pubmed]
  5. Establishment of dorsal-ventral polarity of the Drosophila egg requires capicua action in ovarian follicle cells. Goff, D.J., Nilson, L.A., Morisato, D. Development (2001) [Pubmed]
  6. Spatially distinct downregulation of Capicua repression and tailless activation by the Torso RTK pathway in the Drosophila embryo. de Las Heras, J.M., Casanova, J. Mech. Dev. (2006) [Pubmed]
 
WikiGenes - Universities