The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

IL24  -  interleukin 24

Homo sapiens

Synonyms: C49A, FISP, IL-24, IL10B, Interleukin-24, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IL24


High impact information on IL24


Chemical compound and disease context of IL24


Biological context of IL24


Anatomical context of IL24

  • In this study, we evaluated the effects of overexpressing MDA-7/IL24 in various SMC: the apparently "normal" rat PAC1 cell line, primary human coronary artery SMC, and normal rat aortic SMC [2].
  • IL-19 and IL-24 also exhibited growth inhibition on a cell line endogenously expressing all three receptor subunits, an effect that was seen at cytokine levels two orders of magnitude above those required for STAT activation or proliferation [16].
  • IL-24 (melanoma differentiation-associated gene 7) expression was restricted to monocytes and T cells [17].
  • IL-24 binding to either its endogenous receptors on human keratinocytes or to ectopically expressed receptors on baby hamster kidney cells leads to activation of the signal transducers and activators of transcription [12].
  • Although mda-7 has been designated as IL-24 based on its gene location in the IL-10 locus and its mRNA expression in leukocytes, no functional evidence supporting this cytokine designation exists [18].

Associations of IL24 with chemical compounds


Enzymatic interactions of IL24

  • Cytoplasmic MDA-7 with deleted signal sequence was as effective as full-length MDA-7 in potentiating TNF-induced NF-kappaB reporter activity [23].

Regulatory relationships of IL24


Other interactions of IL24

  • Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types [27].
  • However, the biological effects of these three cytokines appear quite distinct: immune activity with IL-19, skin biology with IL-20, and tumor apoptosis with IL-24 [16].
  • Taken together, these results provide compelling evidence for IL-24 being the fourth member of IL-10 family of cytokines to which their specific receptors have been identified [12].
  • This study defines a tumor-selective cytotoxic bystander role for secreted MDA-7 protein and identifies a novel receptor-mediated, STAT3-independent, and PKR-independent death pathway [13].
  • These molecularly defined N-glycosylated IL-24 dimers elicited dose-dependent secretion of tumor necrosis factor-alpha (TNF-alpha) and IL-6 from human monocytes, as well as cytotoxicity to human melanoma cell lines [28].

Analytical, diagnostic and therapeutic context of IL24


  1. mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer. Chada, S., Bocangel, D., Ramesh, R., Grimm, E.A., Mumm, J.B., Mhashilkar, A.M., Zheng, M. Mol. Ther. (2005) [Pubmed]
  2. Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration. Chen, J., Chada, S., Mhashilkar, A., Miano, J.M. Mol. Ther. (2003) [Pubmed]
  3. Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10. Zheng, M., Bocangel, D., Doneske, B., Mhashilkar, A., Ramesh, R., Hunt, K.K., Ekmekcioglu, S., Sutton, R.B., Poindexter, N., Grimm, E.A., Chada, S. Cancer Immunol. Immunother. (2007) [Pubmed]
  4. IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. Chan, J.R., Blumenschein, W., Murphy, E., Diveu, C., Wiekowski, M., Abbondanzo, S., Lucian, L., Geissler, R., Brodie, S., Kimball, A.B., Gorman, D.M., Smith, K., de Waal Malefyt, R., Kastelein, R.A., McClanahan, T.K., Bowman, E.P. J. Exp. Med. (2006) [Pubmed]
  5. Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice. Sarkar, D., Su, Z.Z., Vozhilla, N., Park, E.S., Gupta, P., Fisher, P.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Sarkar, D., Su, Z.Z., Lebedeva, I.V., Sauane, M., Gopalkrishnan, R.V., Valerie, K., Dent, P., Fisher, P.B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue. Pataer, A., Bocangel, D., Chada, S., Roth, J.A., Hunt, K.K., Swisher, S.G. Cancer Gene Ther. (2007) [Pubmed]
  8. Combined first-pass perfusion and viability study at MR imaging in patients with non-ST segment-elevation acute coronary syndromes: feasibility study. Chiu, C.W., So, N.M., Lam, W.W., Chan, K.Y., Sanderson, J.E. Radiology. (2003) [Pubmed]
  9. Islet cell tumor of the pancreas associated with tumor thrombus in the portal vein. Smith, T.M., Semelka, R.C., Noone, T.C., Balci, N.C., Woosley, J.T. Magnetic resonance imaging. (1999) [Pubmed]
  10. Magnetic resonance imaging of the abdominal aorta and iliac vessels using combined 3-D gadolinium-enhanced MRA and gadolinium-enhanced fat-suppressed spoiled gradient echo sequences. Kelekis, N.L., Semelka, R.C., Worawattanakul, S., Molina, P.L., Mauro, M.A. Magnetic resonance imaging. (1999) [Pubmed]
  11. Synergistic tumoricidal effect between celecoxib and adenoviral-mediated delivery of mda-7 in human breast cancer cells. Suh, Y.J., Chada, S., McKenzie, T., Liu, Y., Swisher, S.G., Lucci, A., Hunt, K.K. Surgery (2005) [Pubmed]
  12. Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. Wang, M., Tan, Z., Zhang, R., Kotenko, S.V., Liang, P. J. Biol. Chem. (2002) [Pubmed]
  13. Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism. Chada, S., Mhashilkar, A.M., Ramesh, R., Mumm, J.B., Sutton, R.B., Bocangel, D., Zheng, M., Grimm, E.A., Ekmekcioglu, S. Mol. Ther. (2004) [Pubmed]
  14. Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients. Tong, A.W., Nemunaitis, J., Su, D., Zhang, Y., Cunningham, C., Senzer, N., Netto, G., Rich, D., Mhashilkar, A., Parker, K., Coffee, K., Ramesh, R., Ekmekcioglu, S., Grimm, E.A., van Wart Hood, J., Merritt, J., Chada, S. Mol. Ther. (2005) [Pubmed]
  15. Cytokine induction of interleukin-24 in human peripheral blood mononuclear cells. Poindexter, N.J., Walch, E.T., Chada, S., Grimm, E.A. J. Leukoc. Biol. (2005) [Pubmed]
  16. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. Parrish-Novak, J., Xu, W., Brender, T., Yao, L., Jones, C., West, J., Brandt, C., Jelinek, L., Madden, K., McKernan, P.A., Foster, D.C., Jaspers, S., Chandrasekher, Y.A. J. Biol. Chem. (2002) [Pubmed]
  17. Cutting edge: immune cells as sources and targets of the IL-10 family members? Wolk, K., Kunz, S., Asadullah, K., Sabat, R. J. Immunol. (2002) [Pubmed]
  18. The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24. Caudell, E.G., Mumm, J.B., Poindexter, N., Ekmekcioglu, S., Mhashilkar, A.M., Yang, X.H., Retter, M.W., Hill, P., Chada, S., Grimm, E.A. J. Immunol. (2002) [Pubmed]
  19. Ionizing radiation enhances therapeutic activity of mda-7/IL-24: overcoming radiation- and mda-7/IL-24-resistance in prostate cancer cells overexpressing the antiapoptotic proteins bcl-xL or bcl-2. Su, Z.Z., Lebedeva, I.V., Sarkar, D., Emdad, L., Gupta, P., Kitada, S., Dent, P., Reed, J.C., Fisher, P.B. Oncogene (2006) [Pubmed]
  20. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Pataer, A., Vorburger, S.A., Barber, G.N., Chada, S., Mhashilkar, A.M., Zou-Yang, H., Stewart, A.L., Balachandran, S., Roth, J.A., Hunt, K.K., Swisher, S.G. Cancer Res. (2002) [Pubmed]
  21. Regulation of mda-7 gene expression during human melanoma differentiation. Madireddi, M.T., Dent, P., Fisher, P.B. Oncogene (2000) [Pubmed]
  22. Coronary artery bypass graft patency: assessment with true ast imaging with steady-state precession versus gadolinium-enhanced MR angiography. Bunce, N.H., Lorenz, C.H., John, A.S., Lesser, J.R., Mohiaddin, R.H., Pennell, D.J. Radiology. (2003) [Pubmed]
  23. Melanoma differentiation-associated gene-7/IL-24 gene enhances NF-kappa B activation and suppresses apoptosis induced by TNF. Aggarwal, S., Takada, Y., Mhashilkar, A.M., Sieger, K., Chada, S., Aggarwal, B.B. J. Immunol. (2004) [Pubmed]
  24. Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways. Sauane, M., Gopalkrishnan, R.V., Lebedeva, I., Mei, M.X., Sarkar, D., Su, Z.Z., Kang, D.C., Dent, P., Pestka, S., Fisher, P.B. J. Cell. Physiol. (2003) [Pubmed]
  25. Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells. Ekmekcioglu, S., Ellerhorst, J.A., Mumm, J.B., Zheng, M., Broemeling, L., Prieto, V.G., Stewart, A.L., Mhashilkar, A.M., Chada, S., Grimm, E.A. Mol. Cancer Ther. (2003) [Pubmed]
  26. Interleukin-24 and its receptors. Wang, M., Liang, P. Immunology (2005) [Pubmed]
  27. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. Dumoutier, L., Leemans, C., Lejeune, D., Kotenko, S.V., Renauld, J.C. J. Immunol. (2001) [Pubmed]
  28. Soluble human MDA-7/IL-24: characterization of the molecular form(s) inhibiting tumor growth and stimulating monocytes. Mumm, J.B., Ekmekcioglu, S., Poindexter, N.J., Chada, S., Grimm, E.A. J. Interferon Cytokine Res. (2006) [Pubmed]
  29. MDA-7/IL-24-based cancer gene therapy: translation from the laboratory to the clinic. Inoue, S., Shanker, M., Miyahara, R., Gopalan, B., Patel, S., Oida, Y., Branch, C.D., Munshi, A., Meyn, R.E., Andreeff, M., Tanaka, F., Mhashilkar, A.M., Chada, S., Ramesh, R. Current gene therapy. (2006) [Pubmed]
  30. BiP/GRP78 Is an Intracellular Target for MDA-7/IL-24 Induction of Cancer-Specific Apoptosis. Gupta, P., Walter, M.R., Su, Z.Z., Lebedeva, I.V., Emdad, L., Randolph, A., Valerie, K., Sarkar, D., Fisher, P.B. Cancer Res. (2006) [Pubmed]
  31. MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine. Sauane, M., Gopalkrishnan, R.V., Sarkar, D., Su, Z.Z., Lebedeva, I.V., Dent, P., Pestka, S., Fisher, P.B. Cytokine Growth Factor Rev. (2003) [Pubmed]
  32. Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties. Huang, E.Y., Madireddi, M.T., Gopalkrishnan, R.V., Leszczyniecka, M., Su, Z., Lebedeva, I.V., Kang, D., Jiang, H., Lin, J.J., Alexandre, D., Chen, Y., Vozhilla, N., Mei, M.X., Christiansen, K.A., Sivo, F., Goldstein, N.I., Mhashilkar, A.B., Chada, S., Huberman, E., Pestka, S., Fisher, P.B. Oncogene (2001) [Pubmed]
WikiGenes - Universities