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Gene Review

IL20  -  interleukin 20

Homo sapiens

Synonyms: Cytokine Zcyto10, IL-20, IL10D, Interleukin-20, UNQ852/PRO1801, ...
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Disease relevance of IL20

  • These results confirm that IL-20 subfamily cytokines are important regulators of epidermal KC biology with potentially pivotal roles in the immunopathology of psoriasis [1].
  • Overexpression of IL-20 in transgenic (TG) mice causes neonatal lethality with skin abnormalities including aberrant epidermal differentiation [2].
  • IL-20: a new target for the treatment of inflammatory skin disease [3].
  • RESULTS: RA patients expressed significantly higher levels of synovial fluid IL-20 than did the rheumatic disease controls [4].
  • We also found that several types of tumor cells stained positive for IL-20, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung [5].

High impact information on IL20

  • Taken together, these results demonstrate a role in epidermal function and psoriasis for IL-20, a novel cytokine identified solely by bioinformatics analysis [2].
  • Recombinant IL-20 protein stimulates a signal transduction pathway through STAT3 in a keratinocyte cell line, demonstrating a direct action of this ligand [2].
  • IL-20 administration to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-20 significantly influences hematopoiesis, with specificity toward multipotential progenitors [6].
  • Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20 [6].
  • Contrary to IL-10, these cytokines signal using receptor complex R1 subunits that are preferentially expressed on cells of epithelial origin; thus, we henceforth refer to them as the IL-20 subfamily cytokines [1].

Chemical compound and disease context of IL20


Biological context of IL20

  • SNPs from two haplotype block regions, one at IL10 and the other from IL19/IL20, were associated with HCV clearance in African Americans (91 clearance cases and 183 chronically infected matched controls; P=0.05-0.002) while with expectation-maximization algorithm-reconstructed haplotypes, these associations remained (P=0.05-0.002) [8].
  • However, the biological effects of these three cytokines appear quite distinct: immune activity with IL-19, skin biology with IL-20, and tumor apoptosis with IL-24 [9].
  • OBJECTIVES: To study the dynamics of IL-19 and IL-20 gene expression as well as the expression of their receptor subunits in psoriatic skin lesions [7].
  • DNA from 473 unaffected controls and 172 patients with sJIA was genotyped for a single nucleotide polymorphism (SNP) in IL19 and IL20 and two SNPs in IL10 [10].
  • The CRF2-s1 gene covers about 28 kb and is located on chromosome 6 in close proximity to the CRF2 members interferon (IFN)-gamma receptor 1 and IL-20 receptor 1 [11].

Anatomical context of IL20


Physical interactions of IL20

  • Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2 [17].
  • IL-19 shares a receptor complex with IL-20, indicating that the biological activities of these two cytokines overlap and that both may play an important role in regulating development and proper functioning of the skin [18].

Regulatory relationships of IL20

  • In pancreatic tumor cells, exogenous MDA-7 protein activates STAT3 and kills cells via engagement of IL-20 receptors [19].
  • Here, we report for the first time that IL-20 downregulates COX-2 and PGE(2) in human bronchial epithelial and endothelial cells [20].

Other interactions of IL20

  • It has also been shown that in the case of IL-19 and IL-20, IL-20R2 rather than IL-20R1 is a high-affinity receptor chain [21].
  • Altogether our findings revealed that IL-20 is a negative modulator of COX-2/PGE(2) and inhibits angiogenesis [20].
  • BACKGROUND: Interleukin (IL)-19, IL-20, and IL-22, three novel cytokines in the IL-10 family, have recently been discovered [22].

Analytical, diagnostic and therapeutic context of IL20


  1. The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis. Sa, S.M., Valdez, P.A., Wu, J., Jung, K., Zhong, F., Hall, L., Kasman, I., Winer, J., Modrusan, Z., Danilenko, D.M., Ouyang, W. J. Immunol. (2007) [Pubmed]
  2. Interleukin 20: discovery, receptor identification, and role in epidermal function. Blumberg, H., Conklin, D., Xu, W.F., Grossmann, A., Brender, T., Carollo, S., Eagan, M., Foster, D., Haldeman, B.A., Hammond, A., Haugen, H., Jelinek, L., Kelly, J.D., Madden, K., Maurer, M.F., Parrish-Novak, J., Prunkard, D., Sexson, S., Sprecher, C., Waggie, K., West, J., Whitmore, T.E., Yao, L., Kuechle, M.K., Dale, B.A., Chandrasekher, Y.A. Cell (2001) [Pubmed]
  3. IL-20: a new target for the treatment of inflammatory skin disease. Rich, B.E. Expert Opin. Ther. Targets (2003) [Pubmed]
  4. Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis. Hsu, Y.H., Li, H.H., Hsieh, M.Y., Liu, M.F., Huang, K.Y., Chin, L.S., Chen, P.C., Cheng, H.H., Chang, M.S. Arthritis Rheum. (2006) [Pubmed]
  5. Tissue microarray analysis of interleukin-20 expression. Hsing, C.H., Ho, C.L., Chang, L.Y., Lee, Y.L., Chuang, S.S., Chang, M.S. Cytokine (2006) [Pubmed]
  6. Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20. Liu, L., Ding, C., Zeng, W., Heuer, J.G., Tetreault, J.W., Noblitt, T.W., Hangoc, G., Cooper, S., Brune, K.A., Sharma, G., Fox, N., Rowlinson, S.W., Rogers, D.P., Witcher, D.R., Lambooy, P.K., Wroblewski, V.J., Miller, J.R., Broxmeyer, H.E. Blood (2003) [Pubmed]
  7. The dynamics of gene expression of interleukin-19 and interleukin-20 and their receptors in psoriasis. Otkjaer, K., Kragballe, K., Funding, A.T., Clausen, J.T., Noerby, P.L., Steiniche, T., Iversen, L. Br. J. Dermatol. (2005) [Pubmed]
  8. Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. Oleksyk, T.K., Thio, C.L., Truelove, A.L., Goedert, J.J., Donfield, S.M., Kirk, G.D., Thomas, D.L., O'Brien, S.J., Smith, M.W. Genes Immun. (2005) [Pubmed]
  9. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. Parrish-Novak, J., Xu, W., Brender, T., Yao, L., Jones, C., West, J., Brandt, C., Jelinek, L., Madden, K., McKernan, P.A., Foster, D.C., Jaspers, S., Chandrasekher, Y.A. J. Biol. Chem. (2002) [Pubmed]
  10. Novel IL10 gene family associations with systemic juvenile idiopathic arthritis. Fife, M.S., Gutierrez, A., Ogilvie, E.M., Stock, C.J., Samuel, J.M., Thomson, W., Mack, L.F., Lewis, C.M., Woo, P. Arthritis Res. Ther. (2006) [Pubmed]
  11. A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta. Gruenberg, B.H., Schoenemeyer, A., Weiss, B., Toschi, L., Kunz, S., Wolk, K., Asadullah, K., Sabat, R. Genes Immun. (2001) [Pubmed]
  12. Cutting edge: immune cells as sources and targets of the IL-10 family members? Wolk, K., Kunz, S., Asadullah, K., Sabat, R. J. Immunol. (2002) [Pubmed]
  13. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. Hör, S., Pirzer, H., Dumoutier, L., Bauer, F., Wittmann, S., Sticht, H., Renauld, J.C., de Waal Malefyt, R., Fickenscher, H. J. Biol. Chem. (2004) [Pubmed]
  14. Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol. Rømer, J., Hasselager, E., Nørby, P.L., Steiniche, T., Thorn Clausen, J., Kragballe, K. J. Invest. Dermatol. (2003) [Pubmed]
  15. Interleukin-20 promotes angiogenesis in a direct and indirect manner. Hsieh, M.Y., Chen, W.Y., Jiang, M.J., Cheng, B.C., Huang, T.Y., Chang, M.S. Genes Immun. (2006) [Pubmed]
  16. Detection of IL-20 and its receptors on psoriatic skin. Wei, C.C., Chen, W.Y., Wang, Y.C., Chen, P.J., Lee, J.Y., Wong, T.W., Chen, W.C., Wu, J.C., Chen, G.Y., Chang, M.S., Lin, Y.C. Clin. Immunol. (2005) [Pubmed]
  17. Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2. Sheikh, F., Baurin, V.V., Lewis-Antes, A., Shah, N.K., Smirnov, S.V., Anantha, S., Dickensheets, H., Dumoutier, L., Renauld, J.C., Zdanov, A., Donnelly, R.P., Kotenko, S.V. J. Immunol. (2004) [Pubmed]
  18. Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. Chang, C., Magracheva, E., Kozlov, S., Fong, S., Tobin, G., Kotenko, S., Wlodawer, A., Zdanov, A. J. Biol. Chem. (2003) [Pubmed]
  19. mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer. Chada, S., Bocangel, D., Ramesh, R., Grimm, E.A., Mumm, J.B., Mhashilkar, A.M., Zheng, M. Mol. Ther. (2005) [Pubmed]
  20. IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. Heuzé-Vourc'h, N., Liu, M., Dalwadi, H., Baratelli, F.E., Zhu, L., Goodglick, L., Põld, M., Sharma, S., Ramirez, R.D., Shay, J.W., Minna, J.D., Strieter, R.M., Dubinett, S.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  21. Structural features of the interleukin-10 family of cytokines. Zdanov, A. Curr. Pharm. Des. (2004) [Pubmed]
  22. Induction of interleukin-19 and interleukin-22 after cardiac surgery with cardiopulmonary bypass. Hsing, C.H., Hsieh, M.Y., Chen, W.Y., Cheung So, E., Cheng, B.C., Chang, M.S. Ann. Thorac. Surg. (2006) [Pubmed]
  23. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Chen, W.Y., Cheng, B.C., Jiang, M.J., Hsieh, M.Y., Chang, M.S. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
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