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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TBXA2R  -  thromboxane A2 receptor

Bos taurus

 
 
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High impact information on TBXA2R

  • Thromboxane A2 (TXA2) receptor antagonist SQ29,548 was used to establish the role of TXA2 receptor in isoprostane effect, as well as to determine the type of receptors involved in these effects [1].
  • In summary, the present studies demonstrate for the first time that primarily small and large luteal cells and secondarily blood vessels and nonluteal cells in bovine corpora lutea express TXA2 receptor gene along with the functional TXA2 synthase [2].
  • These augmented responses to ACh returned to control levels after pretreatment with IND, a thromboxane (TX) synthetase inhibitor (OKY-046; 10 microM) or a TXA2 receptor antagonist (ONO-3708; 10 microM), but not after NDGA pretreatment [3].
  • 3. Prostanoid TP receptor blockade completely inhibited the acute pressor response to ET-1; the change in MAP was 14 2% versus -3 4% in vehicle and SQ29548 groups, respectively (P<0.05) [4].
 

Anatomical context of TBXA2R

 

Associations of TBXA2R with chemical compounds

 

Analytical, diagnostic and therapeutic context of TBXA2R

References

  1. Free-radical-generated F2-isoprostane stimulates cell proliferation and endothelin-1 expression on endothelial cells. Yura, T., Fukunaga, M., Khan, R., Nassar, G.N., Badr, K.F., Montero, A. Kidney Int. (1999) [Pubmed]
  2. Expression of thromboxane A2 receptor gene and thromboxane A2 synthase in bovine corpora lutea. Lei, Z.M., Rao, C.V., Chakraborty, C. Biol. Reprod. (1992) [Pubmed]
  3. Phospholipase A2 augments contraction and intracellular calcium mobilization through thromboxane A2 in bovine tracheal smooth muscle. Takata, Y., Nishimura, Y., Maeda, H., Yokoyama, M. Eur. Respir. J. (1999) [Pubmed]
  4. Contribution of prostanoid tp receptors to the pressor and intrarenal haemodynamic response to endothelin. Williams, J.M., Pollock, D.M. Clin. Exp. Pharmacol. Physiol. (2006) [Pubmed]
  5. The bovine thromboxane A2 receptor: molecular cloning, expression, and functional characterization. Muck, S., Weber, A.A., Meyer-Kirchrath, J., Schrör, K. Naunyn Schmiedebergs Arch. Pharmacol. (1998) [Pubmed]
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