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Gene Review

DGCR8  -  DGCR8 microprocessor complex subunit

Homo sapiens

Synonyms: C22orf12, DGCRK6, DiGeorge syndrome critical region 8, Gy1, LP4941, ...
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Disease relevance of DGCR8


High impact information on DGCR8

  • (2006) report some of the structural features of the primary transcript that ensure that the Drosha-DGCR8 enzyme complex liberates precisely the correct precursor sequence, enabling production of a fully functional miRNA [3].
  • The Drosha-DGCR8 complex initiates microRNA maturation by precise cleavage of the stem loops that are embedded in primary transcripts (pri-miRNAs) [4].
  • The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis [5].
  • The association with heme promotes dimerization of DGCR8 [6].
  • Here we show that the RNA-binding protein DiGeorge critical region-8 (DGCR8), which is essential for the first processing step, is a heme-binding protein [6].

Biological context of DGCR8


Physical interactions of DGCR8

  • In this complex, Drosha interacts with DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains [7].

Other interactions of DGCR8

  • Here we dissected the action mechanism of human Drosha by generating mutants and by characterizing its new interacting partner, DGCR8 [7].


  1. The Microprocessor complex mediates the genesis of microRNAs. Gregory, R.I., Yan, K.P., Amuthan, G., Chendrimada, T., Doratotaj, B., Cooch, N., Shiekhattar, R. Nature (2004) [Pubmed]
  2. RNASEN Regulates Cell Proliferation and Affects Survival in Esophageal Cancer Patients. Sugito, N., Ishiguro, H., Kuwabara, Y., Kimura, M., Mitsui, A., Kurehara, H., Ando, T., Mori, R., Takashima, N., Ogawa, R., Fujii, Y. Clin. Cancer Res. (2006) [Pubmed]
  3. Rethinking the microprocessor. Seitz, H., Zamore, P.D. Cell (2006) [Pubmed]
  4. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Han, J., Lee, Y., Yeom, K.H., Nam, J.W., Heo, I., Rhee, J.K., Sohn, S.Y., Cho, Y., Zhang, B.T., Kim, V.N. Cell (2006) [Pubmed]
  5. The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis. Landthaler, M., Yalcin, A., Tuschl, T. Curr. Biol. (2004) [Pubmed]
  6. Heme is involved in microRNA processing. Faller, M., Matsunaga, M., Yin, S., Loo, J.A., Guo, F. Nat. Struct. Mol. Biol. (2007) [Pubmed]
  7. The Drosha-DGCR8 complex in primary microRNA processing. Han, J., Lee, Y., Yeom, K.H., Kim, Y.K., Jin, H., Kim, V.N. Genes Dev. (2004) [Pubmed]
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