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Gene Review

Sfrp5  -  secreted frizzled-related sequence protein 5

Mus musculus

Synonyms: AI605071, SARP3, Secreted frizzled-related protein 5, sFRP-5
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High impact information on Sfrp5

  • These results indicate that Sfrp5 is not essential for axis formation or foregut morphogenesis in the mouse and also imply that Sfrp5 and Dkk1 together are not essential for AVE development. genesis 44:573-578, 2006 [1].
  • During early post-implantation mouse development Sfrp5 is expressed in the anterior visceral endoderm (AVE) and the ventral foregut endoderm [1].
  • Moreover, the anterior visceral endoderm expresses three secreted Wnt antagonists (Sfrp1, Sfrp5, and Dkk1) in partially overlapping domains [2].
  • We identified ENU-induced point mutations in Sfrp5 and Sfrp2 that are predicted to severely disrupt the function of these genes [3].
  • Between E7.5 and 8, Sfrp5 is expressed in the foregut endoderm underlying the cardiac mesoderm [4].

Biological context of Sfrp5

  • Because of the association between secreted frizzled-related proteins (SFRPs) and apoptosis, their reported developmental expression patterns and the role of WNT signaling in female reproductive tract development, we examined expression of Sfrp2 and Sfrp5 during development of the Müllerian duct in male (XY) and female (XX) mouse embryos [3].

Anatomical context of Sfrp5

  • Additional domains of Sfrp5 expression occur in the dorsal neural tube and in the forebrain anterior to the optic placode [4].
  • At embryonic day (E) 5.5, Sfrp5 is expressed in the visceral endoderm at the distal tip region of the embryo and at E6.5 in the AVE opposite the primitive streak [4].

Analytical, diagnostic and therapeutic context of Sfrp5


  1. Sfrp5 is not essential for axis formation in the mouse. Leaf, I., Tennessen, J., Mukhopadhyay, M., Westphal, H., Shawlot, W. Genesis (2006) [Pubmed]
  2. Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development. Kemp, C., Willems, E., Abdo, S., Lambiv, L., Leyns, L. Dev. Dyn. (2005) [Pubmed]
  3. Sexually dimorphic expression of secreted frizzled-related (SFRP) genes in the developing mouse Müllerian duct. Cox, S., Smith, L., Bogani, D., Cheeseman, M., Siggers, P., Greenfield, A. Mol. Reprod. Dev. (2006) [Pubmed]
  4. The mouse secreted frizzled-related protein 5 gene is expressed in the anterior visceral endoderm and foregut endoderm during early post-implantation development. Finley, K.R., Tennessen, J., Shawlot, W. Gene Expr. Patterns (2003) [Pubmed]
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