The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SFRP5  -  secreted frizzled-related protein 5

Homo sapiens

Synonyms: FRP-1b, FRP1B, Frizzled-related protein 1b, SARP-3, SARP3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SFRP5


Biological context of SFRP5


Anatomical context of SFRP5

  • 3. Based on the biology and complementary expression patterns of SFRP2 and SFRP5, we suggest that they may be involved in determining the polarity of photoreceptor, and perhaps other, cells in the retina [2].

Other interactions of SFRP5

  • Methylation-specific PCR (MSP) analysis showed that SFRP1, SFRP4, and SFRP5 gene promoters are frequently methylated in MM primary tissue (>80%) [7].


  1. SARPs: a family of secreted apoptosis-related proteins. Melkonyan, H.S., Chang, W.C., Shapiro, J.P., Mahadevappa, M., Fitzpatrick, P.A., Kiefer, M.C., Tomei, L.D., Umansky, S.R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. Chang, J.T., Esumi, N., Moore, K., Li, Y., Zhang, S., Chew, C., Goodman, B., Rattner, A., Moody, S., Stetten, G., Campochiaro, P.A., Zack, D.J. Hum. Mol. Genet. (1999) [Pubmed]
  3. Mammary gland tissue targeted overexpression of human protease-activated receptor 1 reveals a novel link to beta-catenin stabilization. Yin, Y.J., Katz, V., Salah, Z., Maoz, M., Cohen, I., Uziely, B., Turm, H., Grisaru-Granovsky, S., Suzuki, H., Bar-Shavit, R. Cancer Res. (2006) [Pubmed]
  4. Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression. Shackel, N.A., McGuinness, P.H., Abbott, C.A., Gorrell, M.D., McCaughan, G.W. Am. J. Pathol. (2002) [Pubmed]
  5. Gene methylation data--a new challenge for bioinformaticians? Goebel, G., Müller, H.M., Fiegl, H., Widschwendter, M. Methods of information in medicine. (2005) [Pubmed]
  6. Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. Hu, E., Zhu, Y., Fredrickson, T., Barnes, M., Kelsell, D., Beeley, L., Brooks, D. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  7. Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Lee, A.Y., He, B., You, L., Dadfarmay, S., Xu, Z., Mazieres, J., Mikami, I., McCormick, F., Jablons, D.M. Oncogene (2004) [Pubmed]
WikiGenes - Universities