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Gene Review

Sfrp2  -  secreted frizzled-related protein 2

Mus musculus

Synonyms: AI851596, Protein SDF5, SARP-1, Sarp1, Sdf5, ...
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High impact information on Sfrp2

  • Moreover, injection of the Wnt antagonists sFRP2/3 into regenerating muscle markedly reduced CD45(+) stem cell proliferation and myogenic specification [1].
  • Moreover, the Wnt antagonist, sFRP-2, partially rescued neural differentiation in JNK1(-/-) cultures [2].
  • Double homozygous mutations in Sfrp1 and Sfrp2 lead to severe shortening of the thoracic region [3].
  • By contrast, a homozygous mutation in one or the other exerts no effect on embryogenesis, indicating that Sfrp1 and Sfrp2 are functionally redundant [3].
  • Histological examination showed that Sarp A also alleviated the TPA-induced inflammatory response and infiltration of phagocytes [4].

Biological context of Sfrp2

  • We identified ENU-induced point mutations in Sfrp5 and Sfrp2 that are predicted to severely disrupt the function of these genes [5].
  • Because of the association between secreted frizzled-related proteins (SFRPs) and apoptosis, their reported developmental expression patterns and the role of WNT signaling in female reproductive tract development, we examined expression of Sfrp2 and Sfrp5 during development of the Müllerian duct in male (XY) and female (XX) mouse embryos [5].
  • Our results suggest that by virtue of its apposition to Wnt-7b expression, SFRP-2 may modulate its function, particularly at boundaries such as the PSB, and that changes in Wnt signaling contribute to the phenotype of Pax-6 mutants [6].
  • Bip, CalP, and CalM are calcium-binding proteins and implicated in calcium homeostasis, whereas SFRP-2 is a negative regulator of Wnt signaling [7].
  • The binding site of SARP is found both in the upper and the lower strands of this fragment [8].

Anatomical context of Sfrp2


Associations of Sfrp2 with chemical compounds

  • Sarcophytol A (Sarp A), a nontoxic compound isolated from marine soft coral, inhibits the in vivo effects of tumor promoters [4].
  • Among the known genes the ufo receptor tyrosine kinase, sFRP2, and the groucho related gene (grg) were verified as being upregulated upon induction [10].

Regulatory relationships of Sfrp2


Other interactions of Sfrp2

  • We show that expression of both Sfrp2 and Sfrp5 is dynamic and sexually dimorphic [5].
  • Moreover, antagonists of Wnt signaling, sFRP1, sFRP2, and sFRP4 (secreted frizzled-related proteins) were significantly up-regulated, suggesting active inhibition of the Wnt pathway [11].
  • We found that Pax-6 mutants lack SFRP-2 expression in the PSB and diencephalon [6].
  • We also noted that Wnt-7b expression was similar to SFRP-2 expression [6].

Analytical, diagnostic and therapeutic context of Sfrp2


  1. Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration. Polesskaya, A., Seale, P., Rudnicki, M.A. Cell (2003) [Pubmed]
  2. Inhibited neurogenesis in JNK1-deficient embryonic stem cells. Amura, C.R., Marek, L., Winn, R.A., Heasley, L.E. Mol. Cell. Biol. (2005) [Pubmed]
  3. Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Satoh, W., Gotoh, T., Tsunematsu, Y., Aizawa, S., Shimono, A. Development (2006) [Pubmed]
  4. Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by sarcophytol A: a possible mechanism of antipromotion. Wei, H., Frenkel, K. Cancer Res. (1992) [Pubmed]
  5. Sexually dimorphic expression of secreted frizzled-related (SFRP) genes in the developing mouse Müllerian duct. Cox, S., Smith, L., Bogani, D., Cheeseman, M., Siggers, P., Greenfield, A. Mol. Reprod. Dev. (2006) [Pubmed]
  6. Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS. Kim, A.S., Anderson, S.A., Rubenstein, J.L., Lowenstein, D.H., Pleasure, S.J. J. Neurosci. (2001) [Pubmed]
  7. Estrogen targets genes involved in protein processing, calcium homeostasis, and Wnt signaling in the mouse uterus independent of estrogen receptor-alpha and -beta. Das, S.K., Tan, J., Raja, S., Halder, J., Paria, B.C., Dey, S.K. J. Biol. Chem. (2000) [Pubmed]
  8. Regulation of gene expression in mammary epithelial cells by cellular confluence and sequence-specific DNA binding factors. Altiok, S., Groner, B. Biochem. Soc. Symp. (1998) [Pubmed]
  9. Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family. Leimeister, C., Bach, A., Gessler, M. Mech. Dev. (1998) [Pubmed]
  10. Screen for genes regulated during early kidney morphogenesis. Leimeister, C., Bach, A., Woolf, A.S., Gessler, M. Dev. Genet. (1999) [Pubmed]
  11. Embryonic myogenesis pathways in muscle regeneration. Zhao, P., Hoffman, E.P. Dev. Dyn. (2004) [Pubmed]
  12. SAGE reveals expression of Wnt signalling pathway members during mouse prostate development. Zhang, T.J., Hoffman, B.G., Ruiz de Algara, T., Helgason, C.D. Gene Expr. Patterns (2006) [Pubmed]
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