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Gene Review

P4HTM  -  prolyl 4-hydroxylase, transmembrane...

Homo sapiens

Synonyms: EGLN4, FLJ20262, HIF-PH4, HIF-prolyl hydroxylase 4, HIFPH4, ...
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Disease relevance of P4HTM


High impact information on P4HTM

  • Such behavior was also shown by recombinant AH1, PH2, and PH4 proteins after expression in Pichia pastoris [3].
  • Prolyl 4-hydroxylases (PH4) catalyze the formation of 4-hydroxyproline in collagens, the major components of the ECM, and are implicated in the hydroxylation of proline in several other secreted proteins [4].
  • Significant growth occurred beyond stages PH3 (PH4 6.54 mm, PH5 8.98 mm) and B3 (B4 7.25 mm, B5 9.41 mm) and from less than 1 year prior to menarche to more than 1 year after menarche (5.92 mm for girls less than 1 year premenarche, 7.88 mm for girls in their first year after menarche, and 9.05 mm for girls more than 1 year beyond menarche) [5].
  • Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors [6].
  • Like EGLNs, PH-4 overexpressed in cellular reporter assays suppressed the HIF transactivation activity, dependent on the consensus ODDD proline residues [6].

Biological context of P4HTM

  • We identified a novel putative proline 4-hydroxylase, PH-4, with an aminoterminal EF-hand motif and a carboxyterminal catalytic domain, which was highly expressed in most organs, and-unlike EGLNs which localize to the cytoplasm and nucleus-was associated with the endoplasmic reticulum [6].


  1. Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress. Siddiq, A., Aminova, L.R., Ratan, R.R. Neurochem. Res. (2007) [Pubmed]
  2. An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha. Koivunen, P., Tiainen, P., Hyvärinen, J., Williams, K.E., Sormunen, R., Klaus, S.J., Kivirikko, K.I., Myllyharju, J. J. Biol. Chem. (2007) [Pubmed]
  3. Investigation of the microheterogeneity and aglycone specificity-conferring residues of black cherry prunasin hydrolases. Zhou, J., Hartmann, S., Shepherd, B.K., Poulton, J.E. Plant Physiol. (2002) [Pubmed]
  4. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams, E.W., Andrew, D.J. Mech. Dev. (2002) [Pubmed]
  5. Nipple (papilla) development in puberty: longitudinal observations in girls. Rohn, R.D. Pediatrics (1987) [Pubmed]
  6. Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. Oehme, F., Ellinghaus, P., Kolkhof, P., Smith, T.J., Ramakrishnan, S., Hütter, J., Schramm, M., Flamme, I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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