Disease relevance of PCLKC

• To investigate the effects of Protocadherin LKC expression in colon cancer, we introduced the gene into colon cancer cell line HCT116, which does not express this gene [1].
• Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation [1].

High impact information on PCLKC

• Our results suggest that Protocadherin LKC, which directly binds PDZ protein, is a molecular switch for contact inhibition of epithelial cells in the liver, kidney and colon tissues [1].
• Significantly, Protocadherin LKC expression induced contact inhibition of cell proliferation although it did not affect growth rate [1].
• Furthermore, expression of Protocadherin LKC suppressed tumor formation of HCT116 cells in a nude mouse model [1].

Anatomical context of PCLKC

• When grown to post-confluence in monolayer cells cultures, Protocadherin LKC-expressing HCT116 no longer formed multiple cell layers and showed the typical paving stone morphology of normal epithelial cells [1].

Analytical, diagnostic and therapeutic context of PCLKC

• The mRNA expression levels of RhoC and protocadherin LKC were confirmed by RT-PCR [2].

References