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MeSH Review

HCT116 Cells



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Disease relevance of HCT116 Cells


High impact information on HCT116 Cells


Chemical compound and disease context of HCT116 Cells


Biological context of HCT116 Cells


Anatomical context of HCT116 Cells


Associations of HCT116 Cells with chemical compounds


Gene context of HCT116 Cells

  • That p21(Cip1/Waf1) expression contributes to the survival of JNK2AS-treated cells was supported by additional experiments demonstrating that p21(Cip1/Waf1) deficiency in HCT116 cells also results in heightened sensitivity to JNKAS treatment [28].
  • Third, tetrandrine increases the expression of p53 and p21(Cip1) in wild-type p53 HCT116 cells [29].
  • Importantly, the level of EGFR activation in growth-arrested HCT116 cells was only slightly higher than that of exponential cells, indicating that it was inappropriate EGFR activation in growth arrest rather than the amplitude of activation that generated growth factor independence [17].
  • The growth factor independence of HCT116 cells was shown to be dependent on autocrine transforming growth factor (TGF)-alpha activity, yet the isoparental HCT116b subcompartment showed similar levels of TGF-alpha expression as HCT116 when cells were in exponential growth [17].
  • Single cell cloning of purged and sorted GPI-anchor- HCT116 cells and sequencing of the PIGA gene in each clone uniformly showed mutations [30].

Analytical, diagnostic and therapeutic context of HCT116 Cells


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  19. Effects of gastrin on 3',5'-cyclic adenosine monophosphate, intracellular calcium, and phosphatidylinositol hydrolysis in human colon cancer cells. Ishizuka, J., Townsend, C.M., Bold, R.J., Martinez, J., Rodriguez, M., Thompson, J.C. Cancer Res. (1994) [Pubmed]
  20. Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. Yamaguchi, H., Bhalla, K., Wang, H.G. Cancer Res. (2003) [Pubmed]
  21. The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells. Berry, S.E., Garces, C., Hwang, H.S., Kunugi, K., Meyers, M., Davis, T.W., Boothman, D.A., Kinsella, T.J. Cancer Res. (1999) [Pubmed]
  22. p21WAF1 regulates anchorage-independent growth of HCT116 colon carcinoma cells via E-cadherin expression. Mueller, S., Cadenas, E., Schönthal, A.H. Cancer Res. (2000) [Pubmed]
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  27. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Hawn, M.T., Umar, A., Carethers, J.M., Marra, G., Kunkel, T.A., Boland, C.R., Koi, M. Cancer Res. (1995) [Pubmed]
  28. Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Potapova, O., Gorospe, M., Dougherty, R.H., Dean, N.M., Gaarde, W.A., Holbrook, N.J. Mol. Cell. Biol. (2000) [Pubmed]
  29. Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. Meng, L.H., Zhang, H., Hayward, L., Takemura, H., Shao, R.G., Pommier, Y. Cancer Res. (2004) [Pubmed]
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  32. Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. Yoon, H.S., Yang, V.W. J. Biol. Chem. (2004) [Pubmed]
  33. Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines. Bentires-Alj, M., Dejardin, E., Viatour, P., Van Lint, C., Froesch, B., Reed, J.C., Merville, M.P., Bours, V. Oncogene (2001) [Pubmed]
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