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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Contact Inhibition

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Disease relevance of Contact Inhibition


High impact information on Contact Inhibition


Chemical compound and disease context of Contact Inhibition


Biological context of Contact Inhibition


Anatomical context of Contact Inhibition


Associations of Contact Inhibition with chemical compounds


Gene context of Contact Inhibition

  • Overall the data indicate that VE-cadherin-beta-catenin complex participates in contact inhibition of VEGF signaling [28].
  • Since these cells were noncycling, we examined whether the ectopic expression of any cyclin could override contact inhibition of growth and restore p53 transactivation function [19].
  • Ectopic expression of S100B in clone 6 cells restores contact inhibition of growth at 37.5 degreesC, which also correlates with nuclear accumulation of the wild-type p53Val135 conformational species [29].
  • They induced morphological alterations and slightly accelerated proliferation in NIH 3T3 fibroblasts but were not tumorigenic in mice and behaved like wild-type Raf-1 in transformation assays measuring loss of contact inhibition or anchorage-independent growth [30].
  • Growth arrest of normal diploid cells by contact inhibition resulted in an induction of p27(kip1) and reduction of CDK2 levels [31].

Analytical, diagnostic and therapeutic context of Contact Inhibition


  1. Oncogenic transformation and inhibition of adipocytic conversion of preadipocytes by TLS/FUS-CHOP type II chimeric protein. Kuroda, M., Ishida, T., Takanashi, M., Satoh, M., Machinami, R., Watanabe, T. Am. J. Pathol. (1997) [Pubmed]
  2. Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells. Joy, A., Moffett, J., Neary, K., Mordechai, E., Stachowiak, E.K., Coons, S., Rankin-Shapiro, J., Florkiewicz, R.Z., Stachowiak, M.K. Oncogene (1997) [Pubmed]
  3. Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Baba, M., Hirai, S., Yamada-Okabe, H., Hamada, K., Tabuchi, H., Kobayashi, K., Kondo, K., Yoshida, M., Yamashita, A., Kishida, T., Nakaigawa, N., Nagashima, Y., Kubota, Y., Yao, M., Ohno, S. Oncogene (2003) [Pubmed]
  4. Association of protein disulfide isomerase activity and the induction of contact inhibition. Clive, D.R., Greene, J.J. Exp. Cell Res. (1994) [Pubmed]
  5. Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. Okazaki, N., Takahashi, N., Kojima, S., Masuho, Y., Koga, H. Carcinogenesis (2002) [Pubmed]
  6. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition. Zhang, H.S., Postigo, A.A., Dean, D.C. Cell (1999) [Pubmed]
  7. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Wang, D., Liebowitz, D., Kieff, E. Cell (1985) [Pubmed]
  8. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Morrison, H., Sherman, L.S., Legg, J., Banine, F., Isacke, C., Haipek, C.A., Gutmann, D.H., Ponta, H., Herrlich, P. Genes Dev. (2001) [Pubmed]
  9. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Polyak, K., Kato, J.Y., Solomon, M.J., Sherr, C.J., Massague, J., Roberts, J.M., Koff, A. Genes Dev. (1994) [Pubmed]
  10. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. West, K.A., Brognard, J., Clark, A.S., Linnoila, I.R., Yang, X., Swain, S.M., Harris, C., Belinsky, S., Dennis, P.A. J. Clin. Invest. (2003) [Pubmed]
  11. Role of oligomannosidic N-glycans in the proliferation, adhesion and signalling of C6 glioblastoma cells. Schraen-Maschke, S., Zanetta, J.P. Biochimie (2003) [Pubmed]
  12. Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis of tumorigenesis. Kaneko, T., Yamashima, T., Tohma, Y., Nomura, M., Imajoh-Ohmi, S., Saido, T.C., Nakao, M., Saya, H., Yamamoto, H., Yamashita, J. Cancer (2001) [Pubmed]
  13. Growth disorders and homocysteine metabolism. McCully, K.S. Ann. Clin. Lab. Sci. (1975) [Pubmed]
  14. The correlation of plasma membrane microvilli and intracellular cyclic AMP content in a rat epitheloid kidney cell line. Carley, W.W., Moses, H.L., Mitchell, W.M. J. Supramol. Struct. (1976) [Pubmed]
  15. Reduced contact-inhibition and substratum adhesion in epithelial cells expressing GlcNAc-transferase V. Demetriou, M., Nabi, I.R., Coppolino, M., Dedhar, S., Dennis, J.W. J. Cell Biol. (1995) [Pubmed]
  16. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. Galbiati, F., Volonte, D., Engelman, J.A., Watanabe, G., Burk, R., Pestell, R.G., Lisanti, M.P. EMBO J. (1998) [Pubmed]
  17. Pak1 and PIX regulate contact inhibition during epithelial wound healing. Zegers, M.M., Forget, M.A., Chernoff, J., Mostov, K.E., ter Beest, M.B., Hansen, S.H. EMBO J. (2003) [Pubmed]
  18. A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer. Kim, S., Chin, K., Gray, J.W., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  19. Cyclin E restores p53 activity in contact-inhibited cells. Deffie, A., Hao, M., Montes de Oca Luna, R., Hulboy, D.L., Lozano, G. Mol. Cell. Biol. (1995) [Pubmed]
  20. Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. Okada, T., Lopez-Lago, M., Giancotti, F.G. J. Cell Biol. (2005) [Pubmed]
  21. Integrin and cadherin synergy regulates contact inhibition of migration and motile activity. Huttenlocher, A., Lakonishok, M., Kinder, M., Wu, S., Truong, T., Knudsen, K.A., Horwitz, A.F. J. Cell Biol. (1998) [Pubmed]
  22. Identification of interferon-modulated proliferation-related cDNA sequences. Kulesh, D.A., Clive, D.R., Zarlenga, D.S., Greene, J.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  23. T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression. Huang, Z.Y., Wu, Y., Hedrick, N., Gutmann, D.H. Mol. Cell. Biol. (2003) [Pubmed]
  24. Vitamin A-induced density-dependent inhibition of L-cell proliferation. Dion, L.D., Blalock, J.E., Gifford, G.E. J. Natl. Cancer Inst. (1977) [Pubmed]
  25. Transfection of neonatal rat Schwann cells with SV-40 large T antigen gene under control of the metallothionein promoter. Tennekoon, G.I., Yoshino, J., Peden, K.W., Bigbee, J., Rutkowski, J.L., Kishimoto, Y., DeVries, G.H., McKhann, G.M. J. Cell Biol. (1987) [Pubmed]
  26. Role of contact inhibition in the regulation of receptor-mediated uptake of low density lipoprotein in cultured vascular endothelial cells. Vlodavsky, I., Fielding, P.E., Fielding, C.J., Gospodarowicz, D. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  27. Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region. Jin, F., Wienecke, R., Xiao, G.H., Maize, J.C., DeClue, J.E., Yeung, R.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  28. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. Grazia Lampugnani, M., Zanetti, A., Corada, M., Takahashi, T., Balconi, G., Breviario, F., Orsenigo, F., Cattelino, A., Kemler, R., Daniel, T.O., Dejana, E. J. Cell Biol. (2003) [Pubmed]
  29. Calcium and S100B regulation of p53-dependent cell growth arrest and apoptosis. Scotto, C., Deloulme, J.C., Rousseau, D., Chambaz, E., Baudier, J. Mol. Cell. Biol. (1998) [Pubmed]
  30. A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation. Dhillon, A.S., Meikle, S., Peyssonnaux, C., Grindlay, J., Kaiser, C., Steen, H., Shaw, P.E., Mischak, H., Eychène, A., Kolch, W. Mol. Cell. Biol. (2003) [Pubmed]
  31. Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect. Kim, Y., Ohyama, H., Patel, V., Figueiredo, M., Wong, D.T. J. Biol. Chem. (2005) [Pubmed]
  32. RNA fingerprinting using arbitrarily primed PCR identifies differentially regulated RNAs in mink lung (Mv1Lu) cells growth arrested by transforming growth factor beta 1. Ralph, D., McClelland, M., Welsh, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  33. Cytomegalovirus and cancer of the prostate: in vitro transformation of human cells. Geder, L., Sanford, E.J., Rohner, T.J., Rapp, F. Cancer treatment reports. (1977) [Pubmed]
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