High impact information on FNBP1L

• In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP [1].
• On the other hand, knockdown of Toca-1 in cultured rat hippocampal neurons enhances axon branching a little but not axon elongation, while knockdown of N-WASP enhances both axon elongation and branching [2].
• Consistently, overexpression of Toca-1 suppresses neurite elongation through the F-BAR/EFC domain with a membrane invaginating property, suggesting an implication of membrane trafficking in the neural function of Toca-1 [2].
• Knockdown of Toca-1 in PC12 cells significantly enhances neurite elongation [2].
• Regulation of Neuronal Morphology by Toca-1, an F-BAR/EFC Protein That Induces Plasma Membrane Invagination [2].

Biological context of FNBP1L

• Exons 1-7 of FNBP1L gene were located within human genome sequence AL512651.13, and exons 7-15 within AL109613.11 [3].
• Complete coding sequence of FNBP1L was determined in silico by assembling nucleotide sequences of FNBP1L exons [3].
• Here, we identified and characterized the FNBP1-like (FNBP1L) gene by using bioinformatics [3].

Anatomical context of FNBP1L

• This is the first report on comprehensive characterization of FNBP1L, which is predicted to function as a scaffold protein for microtubule, Rho family proteins, Formin-homology proteins and WAPS family proteins [3].

Physical interactions of FNBP1L

• Toca-1 interacts directly with N-WASP in filopodia and Rab5 membrane as seen by Forster resonance energy transfer [4].

Other interactions of FNBP1L

• FNBP1L (547 aa) showed 59.4 and 55.4% total-amino-acid identity with FNBP1 and TRIP10, respectively [3].
• FNBP1L gene was linked to SH2D3B/BCAR3 gene in tail-to-tail manner with an interval less than 8 kb within the human genome [3].

References