Disease relevance of WIPI1

• Strikingly, human WIPI genes were found aberrantly expressed in a variety of matched tumor tissues including kidney, pancreatic and skin cancer [1].
• We found that endogenous hWIPI-1 protein colocalizes in part with the autophagosomal marker LC3 at punctate cytoplasmic structures in human melanoma cells [1].

Psychiatry related information on WIPI1

• For the closed set speech perception tests (TAC and WIPI) partitioning best divided-out data at age 4.4 years [2].

High impact information on WIPI1

• Immunofluorescent imaging indicates that WIPI49 is localized to both trans-Golgi and endosomal membranes, organelles between which it traffics in a microtubule-dependent manner [3].
• PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49 [3].
• Our data suggest that WIPI proteins share an evolutionary conserved function in autophagy and that autophagic capacity may be compromised in human cancers [1].
• Atg18 is essential for biogenesis of Cvt vesicles and autophagosomes, while Atg21 is only essential for Cvt vesicle formation [4].
• We have made a retrospective analysis on 70 prelingually deaf children (78% congenital; age range 2-15 years) followed for up to 5 years post-implant during which both closed set speech perception tests (TAC, WIPI) and open set tasks (PBK, GASP) were administered [2].

Analytical, diagnostic and therapeutic context of WIPI1

• Mean TA score on a closed-set word test (WIPI) was 48%, as compared with 32% for hearing aids alone [5].
• Similarly, mean WIPI score for the combination of Tickle Talker, lipreading, and hearing aids (TLA) increased by 6% as compared with combined lipreading and hearing aid (LA) scores [5].

References