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Gene Review

PBK  -  PDZ binding kinase

Homo sapiens

Synonyms: CT84, Cancer/testis antigen 84, FLJ14385, HEL164, Lymphokine-activated killer T-cell-originated protein kinase, ...
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Disease relevance of PBK


Psychiatry related information on PBK

  • RESULTS: The speech perception performance of the 15 children with AN able to complete a PBK-word assessment, fell into two distinct categories [6].
  • Ten SPK recipients died during the study time period [7].

High impact information on PBK

  • We propose that ATR and ATM regulate SPK activity through a feedback mechanism originating at active replicons [8].
  • Analysis of in vitro phosphorylation indicated that SPK phosphorylated specifically a Ser residue in Suc synthase that has been shown to be important for its activity in the degradation of Suc [9].
  • This evidence shows how PBK could link hDlg or other PDZ-containing proteins to signal transduction pathways regulating the cell cycle or cellular proliferation [10].
  • Immunocytochemical analysis with anti-PBK/TOPK antibody implicated a critical role of PBK/TOPK in an early step of mitosis [11].
  • Reduction of PBK/TOPK expression by small interfering RNA resulted in significant suppression of cell growth probably due to dysfunction in the cytokinetic process [11].

Chemical compound and disease context of PBK


Biological context of PBK


Anatomical context of PBK


Associations of PBK with chemical compounds


Physical interactions of PBK


Regulatory relationships of PBK

  • PBK/TOPK and activated serin kinase 2 (PAK2) are novel serin kinases that have recently been identified [21].

Other interactions of PBK


Analytical, diagnostic and therapeutic context of PBK


  1. Protein expression of PDZ-binding kinase is up-regulated in hematologic malignancies and strongly down-regulated during terminal differentiation of HL-60 leukemic cells. Nandi, A., Tidwell, M., Karp, J., Rapoport, A.P. Blood Cells Mol. Dis. (2004) [Pubmed]
  2. PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells. Simons-Evelyn, M., Bailey-Dell, K., Toretsky, J.A., Ross, D.D., Fenton, R., Kalvakolanu, D., Rapoport, A.P. Blood Cells Mol. Dis. (2001) [Pubmed]
  3. Extracellular matrix alterations in human corneas with bullous keratopathy. Ljubimov, A.V., Burgeson, R.E., Butkowski, R.J., Couchman, J.R., Wu, R.R., Ninomiya, Y., Sado, Y., Maguen, E., Nesburn, A.B., Kenney, M.C. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  4. Altered expression of growth factors and cytokines in keratoconus, bullous keratopathy and diabetic human corneas. Saghizadeh, M., Chwa, M., Aoki, A., Lin, B., Pirouzmanesh, A., Brown, D.J., Ljubimov, A.V., Kenney, M.C. Exp. Eye Res. (2001) [Pubmed]
  5. Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. Zhu, F., Zykova, T.A., Kang, B.S., Wang, Z., Ebeling, M.C., Abe, Y., Ma, W.Y., Bode, A.M., Dong, Z. Gastroenterology (2007) [Pubmed]
  6. Speech perception and cortical event related potentials in children with auditory neuropathy. Rance, G., Cone-Wesson, B., Wunderlich, J., Dowell, R. Ear and hearing. (2002) [Pubmed]
  7. The impact of hypoalbuminemia in kidney-pancreas transplant recipients. Becker, B.N., Becker, Y.T., Heisey, D.M., Leverson, G.E., Collins, B.H., Odorico, J.S., D'Alessandro, A.M., Knechtle, S.J., Pirsch, J.D., Sollinger, H.W. Transplantation (1999) [Pubmed]
  8. ATR and ATM regulate the timing of DNA replication origin firing. Shechter, D., Costanzo, V., Gautier, J. Nat. Cell Biol. (2004) [Pubmed]
  9. Rice SPK, a calmodulin-like domain protein kinase, is required for storage product accumulation during seed development: phosphorylation of sucrose synthase is a possible factor. Asano, T., Kunieda, N., Omura, Y., Ibe, H., Kawasaki, T., Takano, M., Sato, M., Furuhashi, H., Mujin, T., Takaiwa, F., Wu Cy, C.Y., Tada, Y., Satozawa, T., Sakamoto, M., Shimada, H. Plant Cell (2002) [Pubmed]
  10. Characterization of PDZ-binding kinase, a mitotic kinase. Gaudet, S., Branton, D., Lue, R.A. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  11. PDZ-Binding Kinase/T-LAK Cell-Originated Protein Kinase, a Putative Cancer/Testis Antigen with an Oncogenic Activity in Breast Cancer. Park, J.H., Lin, M.L., Nishidate, T., Nakamura, Y., Katagiri, T. Cancer Res. (2006) [Pubmed]
  12. Lymphokine-Activated Killer T-Cell-Originated Protein Kinase Phosphorylation of Histone H2AX Prevents Arsenite-Induced Apoptosis in RPMI7951 Melanoma Cells. Zykova, T.A., Zhu, F., Lu, C., Higgins, L., Tatsumi, Y., Abe, Y., Bode, A.M., Dong, Z. Clin. Cancer Res. (2006) [Pubmed]
  13. PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. Dougherty, J.D., Garcia, A.D., Nakano, I., Livingstone, M., Norris, B., Polakiewicz, R., Wexler, E.M., Sofroniew, M.V., Kornblum, H.I., Geschwind, D.H. J. Neurosci. (2005) [Pubmed]
  14. Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. Abe, Y., Matsumoto, S., Kito, K., Ueda, N. J. Biol. Chem. (2000) [Pubmed]
  15. PDZ-binding kinase participates in spermatogenesis. Zhao, S., Dai, J., Zhao, W., Xia, F., Zhou, Z., Wang, W., Gu, S., Ying, K., Xie, Y., Mao, Y. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  16. Characterization of a MAPKK-like protein kinase TOPK. Matsumoto, S., Abe, Y., Fujibuchi, T., Takeuchi, T., Kito, K., Ueda, N., Shigemoto, K., Gyo, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  17. Altered expression of aquaporins in bullous keratopathy and Fuchs' dystrophy corneas. Kenney, M.C., Atilano, S.R., Zorapapel, N., Holguin, B., Gaster, R.N., Ljubimov, A.V. J. Histochem. Cytochem. (2004) [Pubmed]
  18. Expression of PDZ-binding kinase (PBK) is regulated by cell cycle-specific transcription factors E2F and CREB/ATF. Nandi, A.K., Rapoport, A.P. Leuk. Res. (2006) [Pubmed]
  19. PBK modeling for metals. Examples with lead, uranium, and chromium. O'Flaherty, E.J. Toxicol. Lett. (1995) [Pubmed]
  20. ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion! Maruya, S.I., Myers, J.N., Weber, R.S., Rosenthal, D.I., Lotan, R., El-Naggar, A.K. Oral Oncol. (2005) [Pubmed]
  21. Identification and characterization of HLA-class-I-restricted T-cell epitopes in the putative tumor-associated antigens P21-activated serin kinase 2 (PAK2) and cyclin-dependent kinase inhibitor 1A (CDKN1A). Li, G., Hundemer, M., Wolfrum, S., Ho, A.D., Goldschmidt, H., Witzens-Harig, M. Ann. Hematol. (2006) [Pubmed]
  22. Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. Ljubimov, A.V., Saghizadeh, M., Pytela, R., Sheppard, D., Kenney, M.C. J. Histochem. Cytochem. (2001) [Pubmed]
  23. The profile of repeated corneal transplantation. Bersudsky, V., Blum-Hareuveni, T., Rehany, U., Rumelt, S. Ophthalmology (2001) [Pubmed]
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