Disease relevance of KIR2DL5B

• Substitution within a putative binding site for the transcription factor acute myeloid leukemia gene 1 could determine the lack of expression for some KIR2DL5 variants [1].

High impact information on KIR2DL5B

• Ab-mediated cross-linking of KIR2DL5 inhibits NK cell cytotoxicity against murine FcR(+) P815 cells [2].
• Like other MHC class I receptors, KIR2DL5 is also found in a variable proportion of T lymphocytes [2].
• KIR2DL5 is thus an inhibitory receptor gathering a combination of genetic, structural, and functional features unique among KIR, which suggests that KIR2DL5 plays a specialized role in innate immunity [2].
• KIR2DL5 is detected on the cell surface as a monomer of approximately 60 kDa that, upon tyrosine phosphorylation, recruits the Src homology region 2-containing protein tyrosine phosphatase-2 and, to a lesser extent, Src homology region 2-containing protein tyrosine phosphatase-1 [2].
• Haplotype definition included subtyping for the expressed and nonexpressed KIR2DL5 variants, for two alleles of pseudogene 3DP1, and for two alleles of 2DS4, including a novel 2DS4 allele, KIR1D [3].

Biological context of KIR2DL5B

• These results are consistent with a model in which KIR2DL5A and KIR2DL5B are products of a gene duplication, which through the action of subsequent recombination have became separated on some haplotypes [4].
• Comparison of the complete nucleotide sequences of the exons and introns of KIR2DL5.1 and KIR2DL5.2 reveals no structural abnormalities, but similar open reading frames for both variants [1].
• In contrast, the promoter region of KIR2DL5 shows a high degree of sequence polymorphism that is likely relevant for expression [1].

Anatomical context of KIR2DL5B

• Human KIR2DL5 Is an Inhibitory Receptor Expressed on the Surface of NK and T Lymphocyte Subsets [2].

References