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FOXRED1  -  FAD-dependent oxidoreductase domain...

Homo sapiens

Synonyms: FAD-dependent oxidoreductase domain-containing protein 1, FP634, H17
 
 
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Disease relevance of FOXRED1

  • Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay [1].
  • Cage dimeric N-benzyl 4-aryl-1,4-dihydropyridine H17 is a moderate inhibitor of HIV-1 protease [2].
  • First bioanalytical evaluation of nonpeptidic cage dimeric HIV-1 protease inhibitor N-benzyl 4-aryl-1,4-dihydropyridine H17: biotransformation and toxicity on Hep G2 cells [2].
 

High impact information on FOXRED1

  • We have isolated a novel temperature-sensitive lethal mutant named eso1-H17 that displays spindle assembly checkpoint-dependent mitotic delay and abnormal chromosome segregation [3].
  • By contrast, interactions between H6, H15 and H17 near the spur of the 30S ribosome evolved over several minutes, likely due to mispairing of a central helix junction [4].
  • In the human hemoglobin variant Hb Hinsdale, lysine is substituted for asparagine at position beta 139 (H17), which lies in the water-filled cavity that runs through the center of the molecule [5].
  • Here we present data describing selective inhibition of the AP of complement by anti-C3b/iC3b monoclonal antibody (mAb) 3E7, and by a chimeric, "deimmunized" form of this mAb, H17, which contains the human IgG1 Fc region and was further modified by substitution of amino acids in order to remove T cell epitopes [6].
  • Intestinal DMP 323 absorption was mainly increased under co-application of both ritonavir and H17 [7].
 

Chemical compound and disease context of FOXRED1

  • DMP 323 proved to be a P-gp substrate in competition studies with P-gp inhibitor ritonavir and H17 as a representative of another class of non-peptidic HIV-1 protease inhibitors [7].
 

Biological context of FOXRED1

  • In the first bioanalytical evaluation of H17 on Hep G2 monolayers no phase-I metabolites were found and the extent of conjugation on phase-II of biotransformation was poor due to steric hindrance of the hydroxymethylene groups [2].
  • Thus, first biochemical evaluation of H17 practically suggests no decrease of an in-vivo bioavailability by metabolization [2].
 

Anatomical context of FOXRED1

  • We attempted to detect mutagenic activity in bile and pancreatic juice from patients with biliary tract disease using the spore rec assay and wild (H17) and mutant (M45) strains [8].
 

Associations of FOXRED1 with chemical compounds

  • The resulting hemoglobin variant has been designated Hb Aurora [beta 139 (H17) Asn-->Tyr] [9].
  • The two hemoglobins have identical alpha-chains and differ with respect to their beta-chains at the following positions (beta B/beta A): beta NA1 Ac-Ser/Gly, beta A1 Ser/Thr, beta H17 Ser/Asn and beta HC1 Arg/Lys [10].

References

  1. Placental alkaline phosphatase as a tumour marker in seminoma using the H17 E2 monoclonal antibody assay. Horwich, A., Tucker, D.F., Peckham, M.J. Br. J. Cancer (1985) [Pubmed]
  2. First bioanalytical evaluation of nonpeptidic cage dimeric HIV-1 protease inhibitor N-benzyl 4-aryl-1,4-dihydropyridine H17: biotransformation and toxicity on Hep G2 cells. Hilgeroth, A., Langner, A. Arch. Pharm. (Weinheim) (2000) [Pubmed]
  3. Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase. Tanaka, K., Yonekawa, T., Kawasaki, Y., Kai, M., Furuya, K., Iwasaki, M., Murakami, H., Yanagida, M., Okayama, H. Mol. Cell. Biol. (2000) [Pubmed]
  4. Protein-independent folding pathway of the 16S rRNA 5' domain. Adilakshmi, T., Ramaswamy, P., Woodson, S.A. J. Mol. Biol. (2005) [Pubmed]
  5. Chloride masks effects of opposing positive charges in Hb A and Hb Hinsdale (beta 139 Asn-->Lys) that can modulate cooperativity as well as oxygen affinity. Bonaventura, C., Arumugam, M., Cashon, R., Bonaventura, J., Moo-Penn, W.F. J. Mol. Biol. (1994) [Pubmed]
  6. Selective and efficient inhibition of the alternative pathway of complement by a mAb that recognizes C3b/iC3b. DiLillo, D.J., Pawluczkowycz, A.W., Peng, W., Kennedy, A.D., Beum, P.V., Lindorfer, M.A., Taylor, R.P. Mol. Immunol. (2006) [Pubmed]
  7. P-Glycoprotein Effects of Cyclic Urea HIV Protease Inhibitor DMP 323 in Competitional Absorption Studies. Richter, M., Gy??m??nt, N., Moln??r, J., Hilgeroth, A. Arch. Pharm. (Weinheim) (2006) [Pubmed]
  8. Mutagenicity of bile and pancreatic juice from patients with pancreatico-biliary maljunction. Matsubara, T., Tsuji, T., Miyama, A., Yamaguchi, H., Funabiki, T. Hepatogastroenterology (1995) [Pubmed]
  9. Identification of a new high oxygen affinity hemoglobin variant: Hb Aurora [beta 139(H17) Asn-->Tyr]. Lafferty, J., Ali, M., Matthew, K., Eng, B., Patterson, M., Waye, J.S. Hemoglobin (1995) [Pubmed]
  10. The primary structure of hemoglobins from the domestic cat (Felis catus, Felidae). Abbasi, A., Braunitzer, G. Biol. Chem. Hoppe-Seyler (1985) [Pubmed]
 
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