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Gene Review:

TXLNG - taxilin gamma

Homo sapiens

Synonyms: CXorf15, ELRG, Environmental lipopolysaccharide-responding gene protein, FIAT, FLJ11209, ...

Yu, V.W. et al., Dunaeva, M. et al., Nogami, S. et al.

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High impact information on CXorf15

Three ORFs homologous to the Lsr5 gene were found on chromosome I and IV of Arabidopsis indicating that a multigene family of these proteins exists in plants [1].
FIAT/gamma-taxilin localizes to the nucleus in osteoblasts and dimerizes with ATF4 to form inactive dimers, because it does not contain a DNA-binding basic domain moiety [2].

Analytical, diagnostic and therapeutic context of CXorf15

Gamma-taxilin was an uncharacterized protein and Northern blot analysis revealed that gamma-taxilin was ubiquitously expressed [3].

References

Identification of genes expressed in response to light stress in leaves of Arabidopsis thaliana using RNA differential display. Dunaeva, M., Adamska, I. Eur. J. Biochem. (2001) [Pubmed]
Inhibition of ATF4 transcriptional activity by FIAT/gamma-taxilin modulates bone mass accrual. Yu, V.W., Gauthier, C., St-Arnaud, R. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
Identification and characterization of taxilin isoforms. Nogami, S., Satoh, S., Tanaka-Nakadate, S., Yoshida, K., Nakano, M., Terano, A., Shirataki, H. Biochem. Biophys. Res. Commun. (2004) [Pubmed]

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