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STAM2  -  signal transducing adaptor molecule (SH3...

Homo sapiens

Synonyms: HBP, Hbp, Hrs-binding protein, STAM-2, STAM2A, ...
 
 
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High impact information on STAM2

  • We find that overexpression of Hrs causes a strong recruitment of STAM2 to endosome membranes [1].
  • In this paper, we report the crystal structure of the signal transducing adaptor molecule-2 (STAM2) SH3 domain in complex with a peptide with a novel motif derived from a ligand protein, UBPY [2].
  • This molecule is 55% identical to a previously isolated molecule designated signal transducing adaptor molecule (STAM) that was identified as an interleukin (IL)-2-induced phosphoprotein and is therefore designated STAM2 [3].
  • Tyrosine phosphorylation of STAM2 is induced by growth factors such as epidermal growth factor and platelet-derived growth factor as well as by cytokines like IL-3 [3].
  • Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways [3].
 

Biological context of STAM2

 

Physical interactions of STAM2

  • Deletion of a region located N-terminal to the coiled-coil region and conserved among STAM proteins also severely affected Hrs binding and the endosomal localization of STAM2, suggesting that this region is also involved in these activities [4].
 

Other interactions of STAM2

  • A STAM2 mutant that lacks the coiled-coil region and does not bind Hrs, in contrast, mislocalized to the cytoplasm [4].

References

  1. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. Bache, K.G., Raiborg, C., Mehlum, A., Stenmark, H. J. Biol. Chem. (2003) [Pubmed]
  2. Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain. Kaneko, T., Kumasaka, T., Ganbe, T., Sato, T., Miyazawa, K., Kitamura, N., Tanaka, N. J. Biol. Chem. (2003) [Pubmed]
  3. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. Pandey, A., Fernandez, M.M., Steen, H., Blagoev, B., Nielsen, M.M., Roche, S., Mann, M., Lodish, H.F. J. Biol. Chem. (2000) [Pubmed]
  4. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. Mizuno, E., Kawahata, K., Okamoto, A., Kitamura, N., Komada, M. J. Biochem. (2004) [Pubmed]
  5. Splice variant of mouse Stam2 mRNA in nervous and muscle tissue contains additional exon with stop codon within region coding for VHS domain. Curlin, M., Lucić, V., Gajović, S. Croat. Med. J. (2006) [Pubmed]
  6. STAM/EAST/Hbp adapter proteins--integrators of signalling pathways. Lohi, O., Lehto, V.P. FEBS Lett. (2001) [Pubmed]
 
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