High impact information on Rybp

• Together, these findings support critical roles for Rybp at multiple stages of mouse embryogenesis [1].
• Rybp/DEDAF is required for early postimplantation and for central nervous system development [1].
• Specifically, the presence of Rybp-deficient cells resulted in marked forebrain overgrowth and in localized regions of disrupted neural tube closure [1].
• To determine the physiological role of Rybp, we analyzed its expression during mouse development and generated mice carrying a targeted deletion of Rybp using homologous recombination in embryonic stem cells [1].
• Through the use of a chimeric approach, the embryonic lethal phenotype was circumvented and a role for Rybp in central nervous system development was uncovered [1].

Anatomical context of Rybp

• Rybp was found to be broadly expressed during embryogenesis and was particularly abundant in extraembryonic tissues, including trophoblast giant cells [1].

References