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Gene Review

Rybp  -  RING1 and YY1 binding protein

Mus musculus

Synonyms: 2410018J24Rik, DED-associated factor, DEDAF, Death effector domain-associated factor, Dedaf, ...
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High impact information on Rybp

  • Together, these findings support critical roles for Rybp at multiple stages of mouse embryogenesis [1].
  • Rybp/DEDAF is required for early postimplantation and for central nervous system development [1].
  • Specifically, the presence of Rybp-deficient cells resulted in marked forebrain overgrowth and in localized regions of disrupted neural tube closure [1].
  • To determine the physiological role of Rybp, we analyzed its expression during mouse development and generated mice carrying a targeted deletion of Rybp using homologous recombination in embryonic stem cells [1].
  • Through the use of a chimeric approach, the embryonic lethal phenotype was circumvented and a role for Rybp in central nervous system development was uncovered [1].

Anatomical context of Rybp


  1. Rybp/DEDAF is required for early postimplantation and for central nervous system development. Pirity, M.K., Locker, J., Schreiber-Agus, N. Mol. Cell. Biol. (2005) [Pubmed]
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