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Gene Review

Embl1  -  embryonic lethal 1

Mus musculus

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Disease relevance of Embl1


High impact information on Embl1


Biological context of Embl1


Anatomical context of Embl1


Associations of Embl1 with chemical compounds


Other interactions of Embl1


Analytical, diagnostic and therapeutic context of Embl1


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  2. Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. Féral, C.C., Rose, D.M., Han, J., Fox, N., Silverman, G.J., Kaushansky, K., Ginsberg, M.H. J. Clin. Invest. (2006) [Pubmed]
  3. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. Shen, T.L., Park, A.Y., Alcaraz, A., Peng, X., Jang, I., Koni, P., Flavell, R.A., Gu, H., Guan, J.L. J. Cell Biol. (2005) [Pubmed]
  4. Mouse choroideremia gene mutation causes photoreceptor cell degeneration and is not transmitted through the female germline. van den Hurk, J.A., Hendriks, W., van de Pol, D.J., Oerlemans, F., Jaissle, G., Rüther, K., Kohler, K., Hartmann, J., Zrenner, E., van Bokhoven, H., Wieringa, B., Ropers, H.H., Cremers, F.P. Hum. Mol. Genet. (1997) [Pubmed]
  5. Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice. Yagi, H., Deguchi, K., Aono, A., Tani, Y., Kishimoto, T., Komori, T. Blood (1998) [Pubmed]
  6. Interaction of reelin signaling and Lis1 in brain development. Assadi, A.H., Zhang, G., Beffert, U., McNeil, R.S., Renfro, A.L., Niu, S., Quattrocchi, C.C., Antalffy, B.A., Sheldon, M., Armstrong, D.D., Wynshaw-Boris, A., Herz, J., D'Arcangelo, G., Clark, G.D. Nat. Genet. (2003) [Pubmed]
  7. Hop is an unusual homeobox gene that modulates cardiac development. Chen, F., Kook, H., Milewski, R., Gitler, A.D., Lu, M.M., Li, J., Nazarian, R., Schnepp, R., Jen, K., Biben, C., Runke, G., Mackay, J.P., Novotny, J., Schwartz, R.J., Harvey, R.P., Mullins, M.C., Epstein, J.A. Cell (2002) [Pubmed]
  8. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M.F., Taketo, M.M. Cell (1998) [Pubmed]
  9. Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization. Kaneko-Ishino, T., Kuroiwa, Y., Miyoshi, N., Kohda, T., Suzuki, R., Yokoyama, M., Viville, S., Barton, S.C., Ishino, F., Surani, M.A. Nat. Genet. (1995) [Pubmed]
  10. Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death. Löhler, J., Timpl, R., Jaenisch, R. Cell (1984) [Pubmed]
  11. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Chen, W.S., Manova, K., Weinstein, D.C., Duncan, S.A., Plump, A.S., Prezioso, V.R., Bachvarova, R.F., Darnell, J.E. Genes Dev. (1994) [Pubmed]
  12. Deletion and duplication of DNA sequences is associated with the embryonic lethal phenotype of the t9 complementation group of the mouse t complex. Búcan, M., Herrmann, B.G., Frischauf, A.M., Bautch, V.L., Bode, V., Silver, L.M., Martin, G.R., Lehrach, H. Genes Dev. (1987) [Pubmed]
  13. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Kuan, C.Y., Yang, D.D., Samanta Roy, D.R., Davis, R.J., Rakic, P., Flavell, R.A. Neuron (1999) [Pubmed]
  14. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. Babu, J.R., Jeganathan, K.B., Baker, D.J., Wu, X., Kang-Decker, N., van Deursen, J.M. J. Cell Biol. (2003) [Pubmed]
  15. Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethality. Willer, T., Prados, B., Falcón-Pérez, J.M., Renner-Müller, I., Przemeck, G.K., Lommel, M., Coloma, A., Valero, M.C., de Angelis, M.H., Tanner, W., Wolf, E., Strahl, S., Cruces, J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  16. Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis. Wang, Q., Khillan, J., Gadue, P., Nishikura, K. Science (2000) [Pubmed]
  17. Genetic analyses of integrin function in mice. Fässler, R., Georges-Labouesse, E., Hirsch, E. Curr. Opin. Cell Biol. (1996) [Pubmed]
  18. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Kuroda, K., Han, H., Tani, S., Tanigaki, K., Tun, T., Furukawa, T., Taniguchi, Y., Kurooka, H., Hamada, Y., Toyokuni, S., Honjo, T. Immunity (2003) [Pubmed]
  19. LAMP proteins are required for fusion of lysosomes with phagosomes. Huynh, K.K., Eskelinen, E.L., Scott, C.C., Malevanets, A., Saftig, P., Grinstein, S. EMBO J. (2007) [Pubmed]
  20. Functional specialization of calreticulin domains. Nakamura, K., Zuppini, A., Arnaudeau, S., Lynch, J., Ahsan, I., Krause, R., Papp, S., De Smedt, H., Parys, J.B., Muller-Esterl, W., Lew, D.P., Krause, K.H., Demaurex, N., Opas, M., Michalak, M. J. Cell Biol. (2001) [Pubmed]
  21. Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice. Gabriel, H.D., Jung, D., Bützler, C., Temme, A., Traub, O., Winterhager, E., Willecke, K. J. Cell Biol. (1998) [Pubmed]
  22. Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus. Shedlovsky, A., King, T.R., Dove, W.F. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  23. Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Yang, J.T., Rayburn, H., Hynes, R.O. Development (1993) [Pubmed]
  24. The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system. Niederreither, K., Vermot, J., Le Roux, I., Schuhbaur, B., Chambon, P., Dollé, P. Development (2003) [Pubmed]
  25. Positive regulation of Fas gene expression by MSSP and abrogation of Fas-mediated apoptosis induction in MSSP-deficient mice. Nomura, J., Matsumoto, K., Iguchi-Ariga, S.M., Ariga, H. Exp. Cell Res. (2005) [Pubmed]
  26. FES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrow. Keller, P., Payne, J.L., Tremml, G., Greer, P.A., Gaboli, M., Pandolfi, P.P., Bessler, M. J. Exp. Med. (2001) [Pubmed]
  27. Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice. Sirito, M., Lin, Q., Deng, J.M., Behringer, R.R., Sawadogo, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  28. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Grier, J.D., Xiong, S., Elizondo-Fraire, A.C., Parant, J.M., Lozano, G. Mol. Cell. Biol. (2006) [Pubmed]
  29. Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression. de Bruijn, D.R., Peters, W.J., Chuva de Sousa Lopes, S.M., van Dijk, A.H., Willemse, M.P., Pfundt, R., de Boer, P., Geurts van Kessel, A. Hum. Mol. Genet. (2006) [Pubmed]
  30. Rybp/DEDAF is required for early postimplantation and for central nervous system development. Pirity, M.K., Locker, J., Schreiber-Agus, N. Mol. Cell. Biol. (2005) [Pubmed]
  31. WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras. Ioffe, E., Liu, Y., Bhaumik, M., Poirier, F., Factor, S.M., Stanley, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  32. A 191-kb genomic fragment containing the human alpha-globin locus can rescue alpha-thalassemic mice. Al-Hasani, K., Vadolas, J., Knaupp, A.S., Wardan, H., Voullaire, L., Williamson, R., Ioannou, P.A. Mamm. Genome (2005) [Pubmed]
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