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Gene Review

Stub1  -  STIP1 homology and U-Box containing protein 1

Mus musculus

Synonyms: 0610033N24Rik, 2210017D18Rik, 2310040B03Rik, AW046544, CHIP, ...
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High impact information on Stub1

  • At the molecular level, deltaNp63 regulated expression of genes characteristic of the basal layer (K14), interacting (by Chip, luc assay) with the third p53 consensus site [1].
  • METHODS: To this end, we have evaluated the use of Protein Chip technology, coupled with bioinformatics analysis towards discovery of allograft response biomarkers in a mouse skin transplant model [2].
  • By cDNA microarray analysis [NIEHS Mouse Chip (8700 genes); n = 3 individual livers/group, four hybridizations/sample], expression of 36 genes or 220 genes were changed relative to control livers following 6 months of oxazepam or Wy-14,643 treatment, respectively [3].
  • Using a Gene Chip Probe Array, we identified stefin A3, which is known as a cysteine protease inhibitor [4].
  • 400-500 bp PCR products of these 297 genes were printed onto nylon membranes creating the 'ERE Chip' microarray [5].

Anatomical context of Stub1


Analytical, diagnostic and therapeutic context of Stub1

  • We applied Protein Chip technology toward discovery of allograft response markers in this model [2].


  1. Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Candi, E., Rufini, A., Terrinoni, A., Dinsdale, D., Ranalli, M., Paradisi, A., De Laurenzi, V., Spagnoli, L.G., Catani, M.V., Ramadan, S., Knight, R.A., Melino, G. Cell Death Differ. (2006) [Pubmed]
  2. Proteomic analysis of the allograft response. El Essawy, B., Otu, H.H., Choy, B., Zheng, X.X., Libermann, T.A., Strom, T.B. Transplantation (2006) [Pubmed]
  3. Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643. Iida, M., Anna, C.H., Hartis, J., Bruno, M., Wetmore, B., Dubin, J.R., Sieber, S., Bennett, L., Cunningham, M.L., Paules, R.S., Tomer, K.B., Houle, C.D., Merrick, A.B., Sills, R.C., Devereux, T.R. Carcinogenesis (2003) [Pubmed]
  4. LPS induces stefin A3 expression in mouse primary cultured glial cells. Hosoi, T., Suzuki, S., Okuma, Y., Kawakami, A., Ogawa, N., Ozawa, K., Nomura, Y. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  5. Transcription profiling of estrogen target genes in young and old mouse uterus. Khalyfa, A., Klinge, C.M., Hall, W.C., Zhao, X., Miller, M.M., Wang, E. Exp. Gerontol. (2003) [Pubmed]
  6. Detection of immunotoxicity using T-cell based cytokine reporter cell lines ("Cell Chip"). Ringerike, T., Ullerås, E., Völker, R., Verlaan, B., Eikeset, A., Trzaska, D., Adamczewska, V., Olszewski, M., Walczak-Drzewiecka, A., Arkusz, J., van Loveren, H., Nilsson, G., Lovik, M., Dastych, J., Vandebriel, R.J. Toxicology (2005) [Pubmed]
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