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Gene Review

STUB1  -  STIP1 homology and U-box containing...

Homo sapiens

Synonyms: Antigen NY-CO-7, CHIP, CLL-associated antigen KW-8, Carboxy terminus of Hsp70-interacting protein, E3 ubiquitin-protein ligase CHIP, ...
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Disease relevance of STUB1

  • In order to identify genes associated with or functionally involved in metastasis, we have extended our previous transcriptional profile from 5000 to 12,000 genes using the Affymetrix Gene Chip array technology [1].
  • A new three-dimensional biochip platform (Flow-Thru Chip; MetriGenix) was used to develop a rapid and reliable molecular method for the typing and subtyping of influenza viruses [2].
  • RESULTS: Chip-based transcript analysis revealed an up-regulation of ALCAM in prostate cancer in 22% of cases [3].
  • Tumour tissue and adjacent normal tissue were obtained from 21 patients with gastric cancer and then examined for their gene expression profiles by the Gene Chip Human U95Av2 array, which includes 12 000 human genes and EST sequences [4].
  • DIABCARD provides the specification for the core of a Chip Card Based Medical Information System (CCMIS) for the treatment of patients with chronic diseases [5].

Psychiatry related information on STUB1


High impact information on STUB1

  • Immunology. Chip shots--will functional genomics get functional [7]?
  • By determining gene expression profiles using human U95Av2 Gene Chip, we identified 33 novel discriminating genes of which the expression differed significantly between responders and nonresponders [8].
  • Furthermore, we demonstrated that dimerization is a prerequisite for activity of hCHIP in the reconstituted ubiquitination assay [9].
  • A Chip off the Old Block: A Model for the Evolution of Genomic Imprinting via Selection for Parental Similarity [10].
  • EGFR mRNA levels, as measured by Affymetrix U133 Gene Chip microarray hybridization, were available in 63 of these tumors [11].

Biological context of STUB1

  • We analyzed whether Chip affected AR levels using a transient transfection strategy [12].
  • C-terminal Hsp-interacting protein (Chip) is a cochaperone that interacts with Hsp70 and Hsp90 molecular chaperones via a tetratricopeptide domain and inhibits chaperone-dependent protein folding in vitro [12].
  • ChIP-Chip experiments are a new approach to the genomewide identification of transcription factor binding sites and consist of chromatin (Ch) immunoprecipitation (IP) of transcription factor-bound genomic DNA followed by high density oligonucleotide hybridization (Chip) of the IP-enriched DNA [13].
  • Detection of HPV genotypes in cervical lesions by the HPV DNA Chip and sequencing [14].
  • Furthermore, the InSitu Chip system is also suitable for large-scale whole-mount experiments associated with genome, transcriptome, and/or proteome analyses requiring high-throughput, high-quality, and reproducible results [15].

Anatomical context of STUB1

  • "Fluorescent Cell Chip" for immunotoxicity testing: Development of the c-fos expression reporter cell lines [16].
  • The Fluorescent Cell Chip for in vitro immunotoxicity testing employs cell lines derived from lymphocytes, mast cells, and monocytes-macrophages transfected with various EGFP cytokine reporter gene constructs [16].
  • RNA was extracted from microdissected tissue or cultured cell lines and analysed using a custom-made Affymetrix Chip containing 3023 genes, of which 1000 were known to be tumour associated [17].
  • Gingival crevicular fluid (GCF) samples were collected using filter paper strips prior to Chip placement and at 2 h, 4 h, 24 h and 2, 3, 4, 5, 6, 8, and 9 days post-Chip placement [18].
  • Transcriptional profiling (Affymetrix Gene Chip Technology) was performed with cell lines derived from the primary tumor and metastatic lesions such as mesentery, liver and lungs [19].

Associations of STUB1 with chemical compounds

  • Oxidation and reduction of cis- and trans-dichlorodiammine platinum II (cis- and trans-PDD), cis-dichlorobis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole-N3)-p latinum II (cis-Flap), and cis-dichlorobis(isopropylamine)-trans-dihydroxyplatinum IV (Chip) have been studied using pulse radiolysis [20].
  • Stable carbon isotope analysis showed that most birds fed on C3-based foods but Stub-tailed Spadebills (Platyrinchus cancrominus) included C-3- and C-4/CAM-specialist individuals [21].
  • Interview with Chip Holmes, CHE, administrator, Littleton Regional Hospital, Bethlehem, New Hampshire. Interview by Kyle L Grazier [22].

Analytical, diagnostic and therapeutic context of STUB1


  1. Identification of genes associated with metastasis of mammary carcinoma in metastatic versus non-metastatic cell lines. Euer, N., Schwirzke, M., Evtimova, V., Burtscher, H., Jarsch, M., Tarin, D., Weidle, U.H. Anticancer Res. (2002) [Pubmed]
  2. Use of the DNA flow-thru chip, a three-dimensional biochip, for typing and subtyping of influenza viruses. Kessler, N., Ferraris, O., Palmer, K., Marsh, W., Steel, A. J. Clin. Microbiol. (2004) [Pubmed]
  3. ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions. Kristiansen, G., Pilarsky, C., Wissmann, C., Stephan, C., Weissbach, L., Loy, V., Loening, S., Dietel, M., Rosenthal, A. Prostate (2003) [Pubmed]
  4. Gene expression profiles in human gastric cancer: expression of maspin correlates with lymph node metastasis. Terashima, M., Maesawa, C., Oyama, K., Ohtani, S., Akiyama, Y., Ogasawara, S., Takagane, A., Saito, K., Masuda, T., Kanzaki, N., Matsuyama, S., Hoshino, Y., Kogure, M., Gotoh, M., Shirane, M., Mori, K. Br. J. Cancer (2005) [Pubmed]
  5. A chip card for patients with diabetes. Engelbrecht, R., Hildebrand, C., Kühnel, E., Brenner, G., Corcoy, R., Eberhard, G., Gapp, C., Klepser, G., de Leiva, A., Massi-Benedetti, M. Computer methods and programs in biomedicine. (1994) [Pubmed]
  6. DIABCARD CCMIS--a portable and scalable CPR for diabetes care. Gogou, G., Mavromatis, A., Maglaveras, N., Engelbrecht, R., Pappas, C. IEEE transactions on bio-medical engineering. (2002) [Pubmed]
  7. Immunology. Chip shots--will functional genomics get functional? Modlin, R.L., Bloom, B.R. Science (2001) [Pubmed]
  8. Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles. Watanabe, T., Komuro, Y., Kiyomatsu, T., Kanazawa, T., Kazama, Y., Tanaka, J., Tanaka, T., Yamamoto, Y., Shirane, M., Muto, T., Nagawa, H. Cancer Res. (2006) [Pubmed]
  9. Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity. Nikolay, R., Wiederkehr, T., Rist, W., Kramer, G., Mayer, M.P., Bukau, B. J. Biol. Chem. (2004) [Pubmed]
  10. A Chip off the Old Block: A Model for the Evolution of Genomic Imprinting via Selection for Parental Similarity. Spencer, H.G., Clark, A.G. Genetics (2006) [Pubmed]
  11. EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Bhargava, R., Gerald, W.L., Li, A.R., Pan, Q., Lal, P., Ladanyi, M., Chen, B. Mod. Pathol. (2005) [Pubmed]
  12. C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. Cardozo, C.P., Michaud, C., Ost, M.C., Fliss, A.E., Yang, E., Patterson, C., Hall, S.J., Caplan, A.J. Arch. Biochem. Biophys. (2003) [Pubmed]
  13. Multiple testing methods for ChIP-Chip high density oligonucleotide array data. Keleş, S., van der Laan, M.J., Dudoit, S., Cawley, S.E. J. Comput. Biol. (2006) [Pubmed]
  14. Detection of HPV genotypes in cervical lesions by the HPV DNA Chip and sequencing. Choi, Y.D., Jung, W.W., Nam, J.H., Choi, H.S., Park, C.S. Gynecol. Oncol. (2005) [Pubmed]
  15. Rapid and stable buffer exchange system using InSitu Chip suitable for multicolor and large-scale whole-mount analyses. Ogasawara, M., Satoh, N., Shimada, Y., Wang, Z., Tanaka, T., Noji, S. Dev. Genes Evol. (2006) [Pubmed]
  16. "Fluorescent Cell Chip" for immunotoxicity testing: Development of the c-fos expression reporter cell lines. Trzaska, D., Zembek, P., Olszewski, M., Adamczewska, V., Ullerås, E., Dastych, J. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  17. Gene expression profiles of microdissected pancreatic ductal adenocarcinoma. Grützmann, R., Foerder, M., Alldinger, I., Staub, E., Brümmendorf, T., Röpcke, S., Li, X., Kristiansen, G., Jesnowski, R., Sipos, B., Löhr, M., Lüttges, J., Ockert, D., Klöppel, G., Saeger, H.D., Pilarsky, C. Virchows Arch. (2003) [Pubmed]
  18. An in vivo study of the chlorhexidine release profile of the PerioChip in the gingival crevicular fluid, plasma and urine. Soskolne, W.A., Chajek, T., Flashner, M., Landau, I., Stabholtz, A., Kolatch, B., Lerner, E.I. Journal of clinical periodontology. (1998) [Pubmed]
  19. Transcriptional profiling of cell lines derived from an orthotopic pancreatic tumor model reveals metastasis-associated genes. Tarbé, N., Evtimova, V., Burtscher, H., Jarsch, M., Alves, F., Weidle, U.H. Anticancer Res. (2001) [Pubmed]
  20. The radiation chemistry of some platinum-containing radiosensitizers and related compounds. Butler, J., Hoey, B.M., Swallow, A.J. Radiat. Res. (1985) [Pubmed]
  21. Trophic partitioning in tropical rain forest birds: insights from stable isotope analysis. Herrera, L.G., Hobson, K.A., Rodríguez, M., Hernandez, P. Oecologia (2003) [Pubmed]
  22. Interview with Chip Holmes, CHE, administrator, Littleton Regional Hospital, Bethlehem, New Hampshire. Interview by Kyle L Grazier. Holmes, C. Journal of healthcare management / American College of Healthcare Executives. (2005) [Pubmed]
  23. Parameters influencing pulsed flow mixing in microchannels. Glasgow, I., Lieber, S., Aubry, N. Anal. Chem. (2004) [Pubmed]
  24. Surface plasmon resonance biomolecular interaction analysis mass spectrometry. 1. Chip-based analysis. Nelson, R.W., Krone, J.R., Jansson, O. Anal. Chem. (1997) [Pubmed]
  25. Profiling dendritic cell maturation with dedicated microarrays. McIlroy, D., Tanguy-Royer, S., Le Meur, N., Guisle, I., Royer, P.J., Léger, J., Meflah, K., Grégoire, M. J. Leukoc. Biol. (2005) [Pubmed]
  26. Branching out: a molecular fingerprint of endothelial differentiation into tube-like structures generated by Affymetrix oligonucleotide arrays. Gerritsen, M.E., Soriano, R., Yang, S., Zlot, C., Ingle, G., Toy, K., Williams, P.M. Microcirculation (New York, N.Y. : 1994) (2003) [Pubmed]
  27. Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma. Nagtegaal, I.D., Gaspar, C.G., Peltenburg, L.T., Marijnen, C.A., Kapiteijn, E., van de Velde, C.J., Fodde, R., van Krieken, J.H. Virchows Arch. (2005) [Pubmed]
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